STRINGSTRING
TEK TEK UBE3A UBE3A FLT1 FLT1 HCST HCST TSC2 TSC2 EGF EGF CEACAM1 CEACAM1 PTPN6 PTPN6 F2 F2 CD28 CD28 TREM2 TREM2 DCN DCN ROR2 ROR2 CBL CBL EGFR EGFR FGR FGR SRC SRC IGF1 IGF1 PIP5K1C PIP5K1C DAB2IP DAB2IP FSHR FSHR LIME1 LIME1 MAZ MAZ AGAP2 AGAP2 ANGPT1 ANGPT1 STAMBP STAMBP IGF1R IGF1R WNT16 WNT16 NCF1 NCF1 UNC5B UNC5B HAX1 HAX1 LEP LEP ROR1 ROR1 KDR KDR PIP5K1A PIP5K1A PDGFB PDGFB SELP SELP PIP5K1B PIP5K1B FGFR1 FGFR1 PTEN PTEN TGFB2 TGFB2 NTRK2 NTRK2 DIPK2A DIPK2A SERPINE2 SERPINE2 PIK3IP1 PIK3IP1 PTPN13 PTPN13 NLRC3 NLRC3 VEGFA VEGFA SERPINA12 SERPINA12 SLC9A3R1 SLC9A3R1 FLT3 FLT3 FBXL2 FBXL2 ENSPCOP00000024480 ENSPCOP00000024480 PDGFA PDGFA FN1 FN1 RELN RELN CRYBA1 CRYBA1 NKX3-1 NKX3-1 PTK2 PTK2 MYOC MYOC OSM OSM MYDGF MYDGF CRNN CRNN SIRT1 SIRT1 SOX9 SOX9 AGT AGT ENSPCOP00000029403 ENSPCOP00000029403 RGL2 RGL2 PDGFRB PDGFRB PPARD PPARD NEDD4 NEDD4 CSF3 CSF3 SEMA3E SEMA3E PRR5L PRR5L NOP53 NOP53 RASGRP1 RASGRP1 PDGFC PDGFC HGF HGF SEMA4D SEMA4D CEP55 CEP55 PLXNB1 PLXNB1 NTRK1 NTRK1 PIK3AP1 PIK3AP1 PPP1R16B PPP1R16B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TEKTEK receptor tyrosine kinase. (1125 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (870 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
HCSTHematopoietic cell signal transducer. (90 aa)
TSC2TSC complex subunit 2. (1814 aa)
EGFEpidermal growth factor. (1132 aa)
CEACAM1Uncharacterized protein. (523 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (607 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
CD28CD28 molecule. (220 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (224 aa)
DCNDecorin; May affect the rate of fibrils formation. (290 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (943 aa)
CBLCbl proto-oncogene. (891 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
FGRTyrosine-protein kinase. (495 aa)
SRCTyrosine-protein kinase. (543 aa)
IGF1Insulin like growth factor 1. (208 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (682 aa)
DAB2IPDAB2 interacting protein. (1209 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
LIME1Uncharacterized protein. (279 aa)
MAZMYC associated zinc finger protein. (493 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1193 aa)
ANGPT1Angiopoietin 1. (408 aa)
STAMBPSTAM binding protein. (423 aa)
IGF1RTyrosine-protein kinase receptor. (1350 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
UNC5BUnc-5 netrin receptor B. (932 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (278 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (598 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SELPSelectin P. (768 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa)
FGFR1Fibroblast growth factor receptor. (846 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
DIPK2ADivergent protein kinase domain 2A. (430 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
PIK3IP1Phosphoinositide-3-kinase interacting protein 1. (263 aa)
PTPN13Protein tyrosine phosphatase non-receptor type 13. (2494 aa)
NLRC3NLR family CARD domain containing 3. (1103 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (413 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (353 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (949 aa)
FBXL2F-box and leucine rich repeat protein 2. (423 aa)
ENSPCOP00000024480Uncharacterized protein. (103 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FN1Fibronectin 1. (2290 aa)
RELNReelin. (3445 aa)
CRYBA1Crystallin beta A1; Belongs to the beta/gamma-crystallin family. (215 aa)
NKX3-1NK3 homeobox 1. (226 aa)
PTK2Protein tyrosine kinase 2. (1089 aa)
MYOCMyocilin. (504 aa)
OSMOncostatin M. (251 aa)
MYDGFMyeloid derived growth factor. (173 aa)
CRNNCornulin. (386 aa)
SIRT1Sirtuin 1. (743 aa)
SOX9SRY-box transcription factor 9. (505 aa)
AGTAngiotensinogen; Belongs to the serpin family. (484 aa)
ENSPCOP00000029403Protein kinase domain-containing protein. (429 aa)
RGL2Ral guanine nucleotide dissociation stimulator like 2. (778 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
PPARDPeroxisome proliferator activated receptor delta. (440 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1320 aa)
CSF3Colony stimulating factor 3. (199 aa)
SEMA3ESema domain-containing protein; Belongs to the semaphorin family. (390 aa)
PRR5LProline rich 5 like. (368 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (417 aa)
RASGRP1RAS guanyl releasing protein 1. (827 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (284 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (703 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
CEP55Centrosomal protein 55. (456 aa)
PLXNB1Plexin B1. (2135 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (805 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (568 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.