STRINGSTRING
NTRK2 NTRK2 MYOC MYOC OSM OSM CSF3 CSF3 NEDD4 NEDD4 PPARD PPARD PDGFRB PDGFRB RGL2 RGL2 ENSPCOP00000029403 ENSPCOP00000029403 AGT AGT SOX9 SOX9 SIRT1 SIRT1 MYDGF MYDGF PTK2 PTK2 NKX3-1 NKX3-1 RELN RELN FN1 FN1 PDGFA PDGFA PLXNB1 PLXNB1 SEMA4D SEMA4D CBL CBL ROR2 ROR2 DCN DCN SRC SRC IGF1 IGF1 FSHR FSHR TREM2 TREM2 CD28 CD28 F2 F2 MAZ MAZ PTPN6 PTPN6 EGF EGF HCST HCST FLT1 FLT1 UBE3A UBE3A HGF HGF ENSPCOP00000024480 ENSPCOP00000024480 FLT3 FLT3 SERPINA12 SERPINA12 VEGFA VEGFA IGF1R IGF1R ANGPT1 ANGPT1 FGR FGR AGAP2 AGAP2 NTRK1 NTRK1 PIK3AP1 PIK3AP1 SEMA3E SEMA3E PRR5L PRR5L PDGFC PDGFC TEK TEK WNT16 WNT16 NCF1 NCF1 UNC5B UNC5B HAX1 HAX1 LEP LEP ROR1 ROR1 KDR KDR PDGFB PDGFB SELP SELP FGFR1 FGFR1 TGFB2 TGFB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NTRK2Tyrosine-protein kinase receptor. (838 aa)
MYOCMyocilin. (504 aa)
OSMOncostatin M. (251 aa)
CSF3Colony stimulating factor 3. (199 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1320 aa)
PPARDPeroxisome proliferator activated receptor delta. (440 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
RGL2Ral guanine nucleotide dissociation stimulator like 2. (778 aa)
ENSPCOP00000029403Protein kinase domain-containing protein. (429 aa)
AGTAngiotensinogen; Belongs to the serpin family. (484 aa)
SOX9SRY-box transcription factor 9. (505 aa)
SIRT1Sirtuin 1. (743 aa)
MYDGFMyeloid derived growth factor. (173 aa)
PTK2Protein tyrosine kinase 2. (1089 aa)
NKX3-1NK3 homeobox 1. (226 aa)
RELNReelin. (3445 aa)
FN1Fibronectin 1. (2290 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PLXNB1Plexin B1. (2135 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
CBLCbl proto-oncogene. (891 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (943 aa)
DCNDecorin; May affect the rate of fibrils formation. (290 aa)
SRCTyrosine-protein kinase. (543 aa)
IGF1Insulin like growth factor 1. (208 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (224 aa)
CD28CD28 molecule. (220 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
MAZMYC associated zinc finger protein. (493 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (607 aa)
EGFEpidermal growth factor. (1132 aa)
HCSTHematopoietic cell signal transducer. (90 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (870 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (703 aa)
ENSPCOP00000024480Uncharacterized protein. (103 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (949 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (413 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
IGF1RTyrosine-protein kinase receptor. (1350 aa)
ANGPT1Angiopoietin 1. (408 aa)
FGRTyrosine-protein kinase. (495 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1193 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (805 aa)
SEMA3ESema domain-containing protein; Belongs to the semaphorin family. (390 aa)
PRR5LProline rich 5 like. (368 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (284 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
UNC5BUnc-5 netrin receptor B. (932 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (278 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SELPSelectin P. (768 aa)
FGFR1Fibroblast growth factor receptor. (846 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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