(51 nodes) snRNA metabolic process network (Propithecus coquereli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	INTS12	Integrator complex subunit 12. (462 aa)
	SNAPC5	Small nuclear RNA activating complex polypeptide 5. (96 aa)
	INTS6	Integrator complex subunit 6. (866 aa)
	EXOSC8	Exosome component 8. (287 aa)
	INTS1	Integrator complex subunit 1. (2174 aa)
	INTS8	Integrator complex subunit 8. (995 aa)
	METTL4	Methyltransferase like 4; Belongs to the MT-A70-like family. (454 aa)
	EXOSC5	Exosome component 5. (235 aa)
	MEPCE	Methylphosphate capping enzyme. (686 aa)
	EXOSC4	Exosome component 4. (245 aa)
	INTS4	Integrator complex subunit 4. (958 aa)
	ENSPCOP00000018667	RRM_3 domain-containing protein. (103 aa)
	USPL1	Ubiquitin specific peptidase like 1. (1051 aa)
	ZC3H8	Zinc finger CCCH-type containing 8. (306 aa)
	ICE2	Interactor of little elongation complex ELL subunit 2. (944 aa)
	RPAP2	RNA polymerase II associated protein 2. (606 aa)
	INTS3	Integrator complex subunit 3. (1024 aa)
	INTS14	Integrator complex subunit 14. (450 aa)
	USB1	U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate; Belongs to the 2H phosphoesterase superfamily. USB1 family. (265 aa)
	ENSPCOP00000021398	RRM domain-containing protein. (83 aa)
	INTS5	Integrator complex subunit 5. (1019 aa)
	TOE1	Target of EGR1, exonuclease. (507 aa)
	LARP7	Uncharacterized protein. (515 aa)
	ELL	Elongation factor for RNA polymerase II. (618 aa)
	EXOSC7	Exosome component 7. (272 aa)
	ELL3	Elongation factor for RNA polymerase II 3. (396 aa)
	INTS10	Integrator complex subunit 10. (695 aa)
	NOP10	NOP10 ribonucleoprotein. (64 aa)
	INTS9	Integrator complex subunit 9. (646 aa)
	ENSPCOP00000028431	Protein kinase domain-containing protein. (287 aa)
	DKC1	Dyskerin pseudouridine synthase 1. (514 aa)
	SNAPC3	Small nuclear RNA activating complex polypeptide 3. (412 aa)
	METTL16	U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (563 aa)
	EXOSC3	Exosome component 3. (275 aa)
	CDK7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (289 aa)
	SNAPC4	Small nuclear RNA activating complex polypeptide 4. (1412 aa)
	EXOSC9	Exosome component 9. (440 aa)
	INTS13	Integrator complex subunit 13. (706 aa)
	SNAPC1	Small nuclear RNA activating complex polypeptide 1. (369 aa)
	ELL2	Elongation factor for RNA polymerase II 2. (640 aa)
	EXOSC10	Exosome component 10. (878 aa)
	INTS6L	Integrator complex subunit 6 like. (888 aa)
	INTS2	Integrator complex subunit 2. (1199 aa)
	ICE1	Interactor of little elongation complex ELL subunit 1. (2252 aa)
	ENSPCOP00000010476	Uncharacterized protein. (119 aa)
	INTS11	Integrator complex subunit 11. (600 aa)
	TUT1	RRM domain-containing protein. (912 aa)
	EXOSC2	Exosome component 2. (293 aa)
	ENSPCOP00000012386	Uncharacterized protein. (205 aa)
	ENSPCOP00000012561	Uncharacterized protein. (55 aa)
	MTREX	Mtr4 exosome RNA helicase. (952 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DKC1	EXOSC10	ENSPCOP00000028469	ENSPCOP00000005591	Dyskerin pseudouridine synthase 1.	Exosome component 10.	0.473
DKC1	MTREX	ENSPCOP00000028469	ENSPCOP00000012970	Dyskerin pseudouridine synthase 1.	Mtr4 exosome RNA helicase.	0.574
DKC1	NOP10	ENSPCOP00000028469	ENSPCOP00000026468	Dyskerin pseudouridine synthase 1.	NOP10 ribonucleoprotein.	0.999
ELL	ELL2	ENSPCOP00000024549	ENSPCOP00000005529	Elongation factor for RNA polymerase II.	Elongation factor for RNA polymerase II 2.	0.834
ELL	ELL3	ENSPCOP00000024549	ENSPCOP00000026002	Elongation factor for RNA polymerase II.	Elongation factor for RNA polymerase II 3.	0.971
ELL	ENSPCOP00000012561	ENSPCOP00000024549	ENSPCOP00000012561	Elongation factor for RNA polymerase II.	Uncharacterized protein.	0.651
ELL	ENSPCOP00000018667	ENSPCOP00000024549	ENSPCOP00000018667	Elongation factor for RNA polymerase II.	RRM_3 domain-containing protein.	0.429
ELL	ICE1	ENSPCOP00000024549	ENSPCOP00000008753	Elongation factor for RNA polymerase II.	Interactor of little elongation complex ELL subunit 1.	0.569
ELL	ICE2	ENSPCOP00000024549	ENSPCOP00000019720	Elongation factor for RNA polymerase II.	Interactor of little elongation complex ELL subunit 2.	0.895
ELL	INTS11	ENSPCOP00000024549	ENSPCOP00000010804	Elongation factor for RNA polymerase II.	Integrator complex subunit 11.	0.654
ELL	INTS12	ENSPCOP00000024549	ENSPCOP00000013665	Elongation factor for RNA polymerase II.	Integrator complex subunit 12.	0.641
ELL	INTS14	ENSPCOP00000024549	ENSPCOP00000020950	Elongation factor for RNA polymerase II.	Integrator complex subunit 14.	0.544
ELL	INTS3	ENSPCOP00000024549	ENSPCOP00000020386	Elongation factor for RNA polymerase II.	Integrator complex subunit 3.	0.651
ELL	INTS4	ENSPCOP00000024549	ENSPCOP00000018286	Elongation factor for RNA polymerase II.	Integrator complex subunit 4.	0.651
ELL	LARP7	ENSPCOP00000024549	ENSPCOP00000023604	Elongation factor for RNA polymerase II.	Uncharacterized protein.	0.429
ELL	RPAP2	ENSPCOP00000024549	ENSPCOP00000019815	Elongation factor for RNA polymerase II.	RNA polymerase II associated protein 2.	0.632
ELL	USPL1	ENSPCOP00000024549	ENSPCOP00000019139	Elongation factor for RNA polymerase II.	Ubiquitin specific peptidase like 1.	0.554
ELL	ZC3H8	ENSPCOP00000024549	ENSPCOP00000019483	Elongation factor for RNA polymerase II.	Zinc finger CCCH-type containing 8.	0.842
ELL2	ELL	ENSPCOP00000005529	ENSPCOP00000024549	Elongation factor for RNA polymerase II 2.	Elongation factor for RNA polymerase II.	0.834
ELL2	ELL3	ENSPCOP00000005529	ENSPCOP00000026002	Elongation factor for RNA polymerase II 2.	Elongation factor for RNA polymerase II 3.	0.793