STRINGSTRING
GAS6 GAS6 ULK1 ULK1 CDK5R1 CDK5R1 HMGA2 HMGA2 NTRK2 NTRK2 STK32A STK32A TGFBR2 TGFBR2 PRKCZ PRKCZ WNK1 WNK1 MTOR MTOR MAPK9 MAPK9 PRKD1 PRKD1 CAMK1 CAMK1 EPO EPO DGKQ DGKQ PDGFB PDGFB MAST1 MAST1 MAP4K1 MAP4K1 PKD1 PKD1 MAST2 MAST2 HIPK2 HIPK2 RPS6KA5 RPS6KA5 TSSK6 TSSK6 AURKC AURKC MAST3 MAST3 PDPK1 PDPK1 SLC1A1 SLC1A1 PRKCI PRKCI CAB39 CAB39 MORC3 MORC3 PRKDC PRKDC MAPKAPK2 MAPKAPK2 VRK3 VRK3 STK32C STK32C RPS6KA4 RPS6KA4 ULK2 ULK2 PLK2 PLK2 SBK1 SBK1 MARK2 MARK2 ENSPCOP00000007712 ENSPCOP00000007712 ROCK1 ROCK1 RPS6KA6 RPS6KA6 AURKA AURKA PLK1 PLK1 LMTK2 LMTK2 IL24 IL24 LOC105819868 LOC105819868 SYK SYK ENSPCOP00000009588 ENSPCOP00000009588 LOC105823019 LOC105823019 ENSPCOP00000010360 ENSPCOP00000010360 DCLK1 DCLK1 MAP3K13 MAP3K13 AKT1 AKT1 PRKX PRKX NEK7 NEK7 ENSPCOP00000011475 ENSPCOP00000011475 ROCK2 ROCK2 TOP1 TOP1 CDK1 CDK1 EIF2AK3 EIF2AK3 SRPK2 SRPK2 DYRK4 DYRK4 CSNK1G1 CSNK1G1 SMTNL1 SMTNL1 ULK3 ULK3 CSNK2A2 CSNK2A2 TLK1 TLK1 LRRK2 LRRK2 PINK1 PINK1 RIPK1 RIPK1 MYO3B MYO3B DCLK2 DCLK2 PRKAA1 PRKAA1 MAPKAPK5 MAPKAPK5 MARK3 MARK3 NEK6 NEK6 MASTL MASTL AKT2 AKT2 TGFBR1 TGFBR1 SRC SRC STK32B STK32B SMG1 SMG1 RPS6KA2 RPS6KA2 ATM ATM MAPK14 MAPK14 BAK1 BAK1 DCLK3 DCLK3 TBK1 TBK1 ATR ATR NLK NLK CAMK1D CAMK1D MAPK7 MAPK7 PNCK PNCK DYRK1A DYRK1A AURKB AURKB MARK1 MARK1 MAPK12 MAPK12 PBK PBK STK4 STK4 RPS6KB2 RPS6KB2 PRKD2 PRKD2 PKN2 PKN2 LATS1 LATS1 RPS6KA1 RPS6KA1 TSSK4 TSSK4 GSK3A GSK3A VRK1 VRK1 IKBKB IKBKB TLK2 TLK2 CAMK2D CAMK2D CDC7 CDC7 MAPK10 MAPK10 DYRK2 DYRK2 ENSPCOP00000013232 ENSPCOP00000013232 PKN1 PKN1 VRK2 VRK2 GSK3B GSK3B ERN1 ERN1 CSNK2A1 CSNK2A1 HIPK4 HIPK4 PAK2 PAK2 STK38L STK38L CLK1 CLK1 CLSPN CLSPN HIPK3 HIPK3 CAMKV CAMKV BCL2 BCL2 PDK3 PDK3 MKNK2 MKNK2 DYRK1B DYRK1B PRKAA2 PRKAA2 PRKCQ PRKCQ MAST4 MAST4 CAMK1G CAMK1G CHEK2 CHEK2 PRKCD PRKCD UHMK1 UHMK1 CDK5 CDK5 PRKCE PRKCE MAPKAPK3 MAPKAPK3 TTBK1 TTBK1 ENSPCOP00000028883 ENSPCOP00000028883 STK39 STK39 CAMK4 CAMK4 CDK2 CDK2 RPS6KB1 RPS6KB1 PCK1 PCK1 MAP3K10 MAP3K10 TDGF1 TDGF1 MAPK13 MAPK13 RICTOR RICTOR MAPK1 MAPK1 CHUK CHUK PRKCB PRKCB PRKCA PRKCA MAP3K12 MAP3K12 LATS2 LATS2 BRSK2 BRSK2 PKN3 PKN3 MAP3K20 MAP3K20 MKNK1 MKNK1 AKT3 AKT3 GRK2 GRK2 MAPK8 MAPK8 HIPK1 HIPK1 TTBK2 TTBK2 IKBKE IKBKE SGK2 SGK2 MYO3A MYO3A BRSK1 BRSK1 PIKFYVE PIKFYVE DMPK DMPK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAS6Growth arrest specific 6. (648 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1045 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (306 aa)
HMGA2Uncharacterized protein. (117 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
STK32ASerine/threonine kinase 32A. (372 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
WNK1WNK lysine deficient protein kinase 1. (2808 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (860 aa)
CAMK1Calcium/calmodulin dependent protein kinase I. (326 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (194 aa)
DGKQDiacylglycerol kinase. (939 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
MAST1Microtubule associated serine/threonine kinase 1. (1570 aa)
MAP4K1Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (819 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4265 aa)
MAST2Microtubule associated serine/threonine kinase 2. (1794 aa)
HIPK2Homeodomain interacting protein kinase 2. (1187 aa)
RPS6KA5Ribosomal protein S6 kinase A5. (643 aa)
TSSK6Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (273 aa)
AURKCProtein kinase domain-containing protein. (164 aa)
MAST3Microtubule associated serine/threonine kinase 3. (1305 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
SLC1A1Amino acid transporter. (524 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa)
CAB39Calcium binding protein 39. (341 aa)
MORC3MORC family CW-type zinc finger 3. (939 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
VRK3VRK serine/threonine kinase 3. (453 aa)
STK32CSerine/threonine kinase 32C. (420 aa)
RPS6KA4Ribosomal protein S6 kinase. (764 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1036 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
SBK1Serine/threonine-protein kinase SBK1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (422 aa)
MARK2Non-specific serine/threonine protein kinase. (788 aa)
ENSPCOP00000007712Protein kinase domain-containing protein. (266 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1316 aa)
RPS6KA6Non-specific serine/threonine protein kinase. (704 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (402 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
LMTK2Lemur tyrosine kinase 2. (1466 aa)
IL24Interleukin 24. (220 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
SYKSpleen associated tyrosine kinase. (637 aa)
ENSPCOP00000009588Uncharacterized protein. (316 aa)
LOC105823019Uncharacterized protein. (87 aa)
ENSPCOP00000010360AGC-kinase C-terminal domain-containing protein. (86 aa)
DCLK1Doublecortin like kinase 1; Belongs to the protein kinase superfamily. (399 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13. (958 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PRKXUncharacterized protein; Belongs to the protein kinase superfamily. (297 aa)
NEK7NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa)
ENSPCOP00000011475Protein kinase domain-containing protein. (89 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1361 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (762 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
SRPK2SRSF protein kinase 2. (698 aa)
DYRK4Dual specificity tyrosine phosphorylation regulated kinase 4. (513 aa)
CSNK1G1Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (475 aa)
SMTNL1Smoothelin like 1. (447 aa)
ULK3Unc-51 like kinase 3. (486 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (356 aa)
TLK1Tousled like kinase 1. (766 aa)
LRRK2Leucine rich repeat kinase 2. (2427 aa)
PINK1PTEN induced kinase 1. (581 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (643 aa)
MYO3BMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1341 aa)
DCLK2Doublecortin like kinase 2. (782 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
MAPKAPK5MAPK activated protein kinase 5. (478 aa)
MARK3Non-specific serine/threonine protein kinase. (774 aa)
NEK6NIMA related kinase 6; Belongs to the protein kinase superfamily. (313 aa)
MASTLMicrotubule associated serine/threonine kinase like. (672 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (421 aa)
SRCTyrosine-protein kinase. (543 aa)
STK32BSerine/threonine kinase 32B; Belongs to the protein kinase superfamily. (414 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3290 aa)
RPS6KA2Ribosomal protein S6 kinase. (722 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2635 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
DCLK3Doublecortin like kinase 3. (789 aa)
TBK1TANK binding kinase 1. (690 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. (385 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (802 aa)
PNCKPregnancy up-regulated nonubiquitous CaM kinase; Belongs to the protein kinase superfamily. (390 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (714 aa)
AURKBProtein kinase domain-containing protein. (162 aa)
MARK1Non-specific serine/threonine protein kinase. (745 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PBKPDZ binding kinase. (322 aa)
STK4Serine/threonine kinase 4. (487 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
PKN2Protein kinase N2. (983 aa)
LATS1Large tumor suppressor kinase 1. (1131 aa)
RPS6KA1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (745 aa)
TSSK4Testis specific serine kinase 4. (338 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
VRK1VRK serine/threonine kinase 1; Belongs to the protein kinase superfamily. (396 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (747 aa)
TLK2Tousled like kinase 2. (724 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (503 aa)
CDC7Cell division cycle 7. (574 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa)
ENSPCOP00000013232Protein-serine/threonine kinase. (359 aa)
PKN1Protein kinase N1. (838 aa)
VRK2VRK serine/threonine kinase 2. (391 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (390 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (935 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
HIPK4Homeodomain interacting protein kinase 4; Belongs to the protein kinase superfamily. (397 aa)
PAK2Non-specific serine/threonine protein kinase. (492 aa)
STK38LNon-specific serine/threonine protein kinase. (395 aa)
CLK1CDC like kinase 1. (523 aa)
CLSPNClaspin. (1329 aa)
HIPK3Homeodomain interacting protein kinase 3. (1129 aa)
CAMKVCaM kinase like vesicle associated. (472 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
PDK3Protein-serine/threonine kinase. (352 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (468 aa)
DYRK1BDual specificity tyrosine phosphorylation regulated kinase 1B. (629 aa)
PRKAA2Non-specific serine/threonine protein kinase. (553 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
MAST4Microtubule associated serine/threonine kinase family member 4. (2535 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
CHEK2Checkpoint kinase 2. (571 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
UHMK1U2AF homology motif kinase 1. (419 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
TTBK1Protein kinase domain-containing protein. (668 aa)
ENSPCOP00000028883Protein kinase domain-containing protein. (138 aa)
STK39Serine/threonine kinase 39. (522 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (959 aa)
TDGF1Teratocarcinoma-derived growth factor 1. (186 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1646 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (682 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PRKCAUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (891 aa)
LATS2Non-specific serine/threonine protein kinase. (1073 aa)
BRSK2BR serine/threonine kinase 2. (721 aa)
PKN3Protein kinase N3. (889 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
MKNK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (427 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
HIPK1Homeodomain interacting protein kinase 1. (1131 aa)
TTBK2Tau tubulin kinase 2. (1221 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (406 aa)
MYO3AMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1426 aa)
BRSK1BR serine/threonine kinase 1. (736 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2053 aa)
DMPKDM1 protein kinase. (630 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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