STRINGSTRING
MET MET LYN LYN DSTYK DSTYK EFNA4 EFNA4 DYRK1A DYRK1A EPHB1 EPHB1 EGF EGF CNTF CNTF FER FER EFEMP1 EFEMP1 PBK PBK ENSPCOP00000013931 ENSPCOP00000013931 PTPN6 PTPN6 IGF2R IGF2R ROS1 ROS1 PTPN4 PTPN4 JAK1 JAK1 CLK1 CLK1 EPHB6 EPHB6 RYK RYK MATK MATK SCYL1 SCYL1 HIPK3 HIPK3 EPHA4 EPHA4 ROR2 ROR2 HCK HCK ENSPCOP00000011592 ENSPCOP00000011592 CRIM1 CRIM1 ENSPCOP00000011171 ENSPCOP00000011171 CD3E CD3E IL12RB2 IL12RB2 NTRK1 NTRK1 TNK1 TNK1 FRK FRK EPHA2 EPHA2 WEE2 WEE2 PDGFRL PDGFRL LCK LCK FLT4 FLT4 LOC105822409 LOC105822409 SYK SYK PRLR PRLR CD4 CD4 TEK TEK FYN FYN CLK4 CLK4 MAPK3 MAPK3 ABI1 ABI1 FGFRL1 FGFRL1 NEK1 NEK1 CAV1 CAV1 DYRK4 DYRK4 IL21 IL21 MAP2K6 MAP2K6 INSR INSR PTK2 PTK2 TTBK1 TTBK1 EPHA1 EPHA1 PEAK1 PEAK1 PDGFRA PDGFRA TYRO3 TYRO3 PRKCD PRKCD CSF1R CSF1R ENSPCOP00000026958 ENSPCOP00000026958 ZAP70 ZAP70 BMX BMX STYK1 STYK1 ERBB3 ERBB3 NTRK3 NTRK3 PTK2B PTK2B FGFR3 FGFR3 HIPK1 HIPK1 ERBB2 ERBB2 FGFR4 FGFR4 TXK TXK NOD2 NOD2 MAP3K11 MAP3K11 ENSPCOP00000029403 ENSPCOP00000029403 CLK2 CLK2 BTK BTK CHKA CHKA FGFR2 FGFR2 CSK CSK MAP3K10 MAP3K10 PDGFRB PDGFRB STK16 STK16 IL2 IL2 ENSPCOP00000030916 ENSPCOP00000030916 PTPN9 PTPN9 FES FES RSRC2 RSRC2 MAP2K4 MAP2K4 MAP2K3 MAP2K3 ENSPCOP00000031725 ENSPCOP00000031725 ITK ITK RELN RELN ENSPCOP00000024844 ENSPCOP00000024844 BAZ1B BAZ1B ABL1 ABL1 RIPK2 RIPK2 BRAF BRAF FLT3 FLT3 SRMS SRMS DYRK3 DYRK3 VEGFA VEGFA LTK LTK ABI2 ABI2 KIT KIT RET RET AXL AXL TNK2 TNK2 MST1R MST1R EPHA3 EPHA3 PKDCC PKDCC PIBF1 PIBF1 CLK3 CLK3 AATK AATK MUSK MUSK KITLG KITLG DYRK2 DYRK2 IGF1R IGF1R HPX HPX EPHB4 EPHB4 DYRK1B DYRK1B ENSPCOP00000019705 ENSPCOP00000019705 MAP3K9 MAP3K9 ENSPCOP00000019408 ENSPCOP00000019408 EPHB3 EPHB3 INSRR INSRR DDR2 DDR2 SRC SRC FGR FGR EGFR EGFR ABL2 ABL2 TEC TEC IL5 IL5 BLK BLK EIF2AK2 EIF2AK2 LRRK1 LRRK1 LEP LEP ALK ALK HTR2A HTR2A ENSPCOP00000005631 ENSPCOP00000005631 ROR1 ROR1 KDR KDR TESK1 TESK1 RPS6KA5 RPS6KA5 JAK3 JAK3 HIPK2 HIPK2 MERTK MERTK PDGFB PDGFB MAP2K7 MAP2K7 FGFR1 FGFR1 CAMKK2 CAMKK2 TYK2 TYK2 NTRK2 NTRK2 ENSPCOP00000000722 ENSPCOP00000000722 EPHB2 EPHB2 LIF LIF IL15 IL15 ENSPCOP00000018060 ENSPCOP00000018060 EPHA8 EPHA8 IL4 IL4 EPHA10 EPHA10 TIE1 TIE1 WEE1 WEE1 TTK TTK NRP1 NRP1 MAP2K5 MAP2K5 DDR1 DDR1 FLT1 FLT1 NRP2 NRP2 BCR BCR EFNB3 EFNB3 SPINK1 SPINK1 MAP2K1 MAP2K1 MELK MELK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
METMET proto-oncogene, receptor tyrosine kinase. (1397 aa)
LYNTyrosine-protein kinase. (512 aa)
DSTYKDual serine/threonine and tyrosine protein kinase. (928 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (201 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (714 aa)
EPHB1EPH receptor B1. (984 aa)
EGFEpidermal growth factor. (1132 aa)
CNTFCiliary neurotrophic factor. (198 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (493 aa)
PBKPDZ binding kinase. (322 aa)
ENSPCOP00000013931Eph LBD domain-containing protein. (358 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (607 aa)
IGF2RInsulin like growth factor 2 receptor. (2496 aa)
ROS1Tyrosine-protein kinase receptor. (2630 aa)
PTPN4Protein tyrosine phosphatase non-receptor type 4. (831 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
CLK1CDC like kinase 1. (523 aa)
EPHB6EPH receptor B6. (1019 aa)
RYKReceptor like tyrosine kinase. (606 aa)
MATKTyrosine-protein kinase. (507 aa)
SCYL1SCY1 like pseudokinase 1. (805 aa)
HIPK3Homeodomain interacting protein kinase 3. (1129 aa)
EPHA4EPH receptor A4. (976 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (943 aa)
HCKTyrosine-protein kinase. (524 aa)
ENSPCOP00000011592Uncharacterized protein. (80 aa)
CRIM1Cysteine rich transmembrane BMP regulator 1. (1037 aa)
ENSPCOP00000011171Uncharacterized protein. (575 aa)
CD3ECD3e molecule. (187 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (780 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
TNK1Tyrosine kinase non receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (662 aa)
FRKTyrosine-protein kinase. (508 aa)
EPHA2EPH receptor A2. (976 aa)
WEE2Wee1-like protein kinase. (566 aa)
PDGFRLPlatelet derived growth factor receptor like. (356 aa)
LCKTyrosine-protein kinase. (417 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1341 aa)
LOC105822409Eph LBD domain-containing protein. (279 aa)
SYKSpleen associated tyrosine kinase. (637 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (523 aa)
CD4CD4 molecule. (452 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
FYNTyrosine-protein kinase. (537 aa)
CLK4CDC like kinase 4; Belongs to the protein kinase superfamily. (436 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
ABI1Abl interactor 1. (508 aa)
FGFRL1Fibroblast growth factor receptor like 1. (509 aa)
NEK1NIMA related kinase 1. (1097 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
DYRK4Dual specificity tyrosine phosphorylation regulated kinase 4. (513 aa)
IL21Interleukin 21. (110 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (345 aa)
INSRInsulin receptor. (1192 aa)
PTK2Protein tyrosine kinase 2. (1089 aa)
TTBK1Protein kinase domain-containing protein. (668 aa)
EPHA1EPH receptor A1. (942 aa)
PEAK1Pseudopodium enriched atypical kinase 1. (1752 aa)
PDGFRAPlatelet derived growth factor receptor alpha; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1027 aa)
TYRO3TYRO3 protein tyrosine kinase. (896 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
ENSPCOP00000026958Uncharacterized protein. (5601 aa)
ZAP70Tyrosine-protein kinase. (617 aa)
BMXTyrosine-protein kinase. (627 aa)
STYK1Serine/threonine/tyrosine kinase 1. (404 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1337 aa)
NTRK3Tyrosine-protein kinase receptor. (865 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (967 aa)
FGFR3Fibroblast growth factor receptor. (807 aa)
HIPK1Homeodomain interacting protein kinase 1. (1131 aa)
ERBB2Receptor protein-tyrosine kinase. (1252 aa)
FGFR4Fibroblast growth factor receptor. (797 aa)
TXKTyrosine-protein kinase. (581 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (847 aa)
ENSPCOP00000029403Protein kinase domain-containing protein. (429 aa)
CLK2CDC like kinase 2; Belongs to the protein kinase superfamily. (500 aa)
BTKTyrosine-protein kinase. (647 aa)
CHKACholine kinase alpha. (449 aa)
FGFR2Fibroblast growth factor receptor. (797 aa)
CSKTyrosine-protein kinase. (450 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (959 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
STK16Serine/threonine kinase 16. (349 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
ENSPCOP00000030916Uncharacterized protein. (524 aa)
PTPN9Protein tyrosine phosphatase non-receptor type 9. (593 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (821 aa)
RSRC2Arginine and serine rich coiled-coil 2. (443 aa)
MAP2K4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
ENSPCOP00000031725Protein kinase domain-containing protein. (272 aa)
ITKTyrosine-protein kinase. (598 aa)
RELNReelin. (3445 aa)
ENSPCOP00000024844Uncharacterized protein. (639 aa)
BAZ1BBromodomain adjacent to zinc finger domain 1B. (1482 aa)
ABL1Tyrosine-protein kinase. (1146 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (539 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (949 aa)
SRMSTyrosine-protein kinase. (496 aa)
DYRK3Dual specificity tyrosine phosphorylation regulated kinase 3. (588 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
LTKTyrosine-protein kinase receptor. (888 aa)
ABI2Abl interactor 2. (513 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1079 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
TNK2Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1088 aa)
MST1RMacrophage stimulating 1 receptor. (1403 aa)
EPHA3EPH receptor A3. (831 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (492 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (663 aa)
CLK3CDC like kinase 3. (638 aa)
AATKApoptosis associated tyrosine kinase. (1335 aa)
MUSKMuscle associated receptor tyrosine kinase. (826 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa)
IGF1RTyrosine-protein kinase receptor. (1350 aa)
HPXHemopexin. (466 aa)
EPHB4EPH receptor B4. (987 aa)
DYRK1BDual specificity tyrosine phosphorylation regulated kinase 1B. (629 aa)
ENSPCOP00000019705Uncharacterized protein. (583 aa)
MAP3K9Mitogen-activated protein kinase kinase kinase. (1103 aa)
ENSPCOP00000019408SMAP domain-containing protein. (193 aa)
EPHB3EPH receptor B3. (1009 aa)
INSRRTyrosine-protein kinase receptor. (1272 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
SRCTyrosine-protein kinase. (543 aa)
FGRTyrosine-protein kinase. (495 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ABL2Tyrosine-protein kinase. (1154 aa)
TECTyrosine-protein kinase. (625 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (133 aa)
BLKTyrosine-protein kinase. (500 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (549 aa)
LRRK1Leucine rich repeat kinase 1. (2012 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ALKTyrosine-protein kinase receptor. (1578 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
ENSPCOP00000005631Protein kinase domain-containing protein. (159 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
TESK1Testis associated actin remodelling kinase 1. (628 aa)
RPS6KA5Ribosomal protein S6 kinase A5. (643 aa)
JAK3Tyrosine-protein kinase. (1123 aa)
HIPK2Homeodomain interacting protein kinase 2. (1187 aa)
MERTKMER proto-oncogene, tyrosine kinase. (998 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
FGFR1Fibroblast growth factor receptor. (846 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (587 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
ENSPCOP00000000722Protein kinase domain-containing protein. (67 aa)
EPHB2EPH receptor B2. (1039 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (135 aa)
ENSPCOP00000018060SMAP domain-containing protein. (331 aa)
EPHA8EPH receptor A8. (1006 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
EPHA10EPH receptor A10. (1008 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1143 aa)
WEE1Wee1-like protein kinase. (558 aa)
TTKTTK protein kinase. (753 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
MAP2K5Mitogen-activated protein kinase kinase 5. (389 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (913 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (932 aa)
BCRBCR activator of RhoGEF and GTPase. (1168 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (343 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (78 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
MELKNon-specific serine/threonine protein kinase. (493 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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