STRINGSTRING
TGFA TGFA AR AR FEM1B FEM1B TP63 TP63 SFRP1 SFRP1 FGFR2 FGFR2 LRRC1 LRRC1 SOX9 SOX9 PLXND1 PLXND1 PAX6 PAX6 LRP5 LRP5 CEBPB CEBPB BMP4 BMP4 PGR PGR POLB POLB CSMD2 CSMD2 CSF1R CSF1R FGF7 FGF7 SELENOH SELENOH ARG1 ARG1 NKX3-1 NKX3-1 CAV1 CAV1 DAG1 DAG1 ESR1 ESR1 TGFB1 TGFB1 PTCH1 PTCH1 LOC105826415 LOC105826415 WNT4 WNT4 ESRP2 ESRP2 SCRIB SCRIB EDAR EDAR CYP7B1 CYP7B1 BCL2 BCL2 NRG3 NRG3 PML PML FRS2 FRS2 ELF3 ELF3 SRC SRC GDF7 GDF7 ENSPCOP00000018033 ENSPCOP00000018033 BTRC BTRC NRP1 NRP1 DDR1 DDR1 HOXA13 HOXA13 LAMA5 LAMA5 RARG RARG TNF TNF DUOX2 DUOX2 ID4 ID4 HOXD13 HOXD13 NKX2-3 NKX2-3 KDM5B KDM5B PROX1 PROX1 BSX BSX RPS6KA1 RPS6KA1 HOXB13 HOXB13 VDR VDR FGF8 FGF8 TWSG1 TWSG1 CSMD1 CSMD1 FOXA1 FOXA1 NFIB NFIB EPHA2 EPHA2 TNC TNC TGM2 TGM2 IL6 IL6 NFKB1 NFKB1 MMP2 MMP2 WNT5A WNT5A SOSTDC1 SOSTDC1 LOC105822779 LOC105822779 TGFB3 TGFB3 CSF1 CSF1 STAT6 STAT6 SERPINB5 SERPINB5 NTN1 NTN1 EDA EDA ENSPCOP00000005396 ENSPCOP00000005396 MED1 MED1 AREG AREG NOTCH1 NOTCH1 TBX2 TBX2 BMP7 BMP7 CUL3 CUL3 LAMA1 LAMA1 NOTCH2 NOTCH2 MST1 MST1 TGFBR2 TGFBR2 TGFB2 TGFB2 PLAG1 PLAG1 FGF10 FGF10 NOG NOG ENSPCOP00000000775 ENSPCOP00000000775 GLI3 GLI3 IGFBP5 IGFBP5 MSN MSN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFATransforming growth factor alpha. (190 aa)
ARAndrogen receptor. (886 aa)
FEM1BFem-1 homolog B. (627 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
FGFR2Fibroblast growth factor receptor. (797 aa)
LRRC1Leucine rich repeat containing 1. (484 aa)
SOX9SRY-box transcription factor 9. (505 aa)
PLXND1Plexin D1. (1928 aa)
PAX6Paired box 6. (453 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
PGRNuclear receptor domain-containing protein. (592 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (333 aa)
CSMD2CUB and Sushi multiple domains 2. (3597 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
SELENOHSelenoprotein H. (121 aa)
ARG1Arginase. (229 aa)
NKX3-1NK3 homeobox 1. (226 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
DAG1Dystroglycan 1. (895 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (599 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PTCH1Patched 1. (1449 aa)
LOC105826415Uncharacterized protein. (820 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ESRP2Epithelial splicing regulatory protein 2. (715 aa)
SCRIBScribble planar cell polarity protein. (1598 aa)
EDAREctodysplasin A receptor. (463 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (506 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
NRG3Neuregulin 3. (721 aa)
PMLPromyelocytic leukemia. (887 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
ELF3E74 like ETS transcription factor 3. (372 aa)
SRCTyrosine-protein kinase. (543 aa)
GDF7Growth differentiation factor 7. (447 aa)
ENSPCOP00000018033HH_signal domain-containing protein. (110 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (609 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (913 aa)
HOXA13Homeobox A13. (366 aa)
LAMA5Laminin subunit alpha 5. (3694 aa)
RARGRetinoic acid receptor gamma. (458 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
DUOX2Dual oxidase 2. (1540 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
HOXD13Homeobox D13. (347 aa)
NKX2-3NK2 homeobox 3. (361 aa)
KDM5BLysine demethylase 5B. (1544 aa)
PROX1Prospero homeobox 1. (737 aa)
BSXBrain specific homeobox. (232 aa)
RPS6KA1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (745 aa)
HOXB13Homeobox B13. (284 aa)
VDRVitamin D receptor. (474 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (189 aa)
CSMD1CUB and Sushi multiple domains 1. (3147 aa)
FOXA1Forkhead box A1. (472 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
EPHA2EPH receptor A2. (976 aa)
TNCUncharacterized protein. (2138 aa)
TGM2Transglutaminase 2. (542 aa)
IL6Uncharacterized protein. (211 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
MMP2Matrix metallopeptidase 2. (552 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SOSTDC1Sclerostin domain containing 1. (229 aa)
LOC105822779Uncharacterized protein. (325 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CSF1Colony stimulating factor 1. (438 aa)
STAT6Signal transducer and activator of transcription. (846 aa)
SERPINB5Serpin family B member 5; Belongs to the serpin family. (375 aa)
NTN1Netrin 1. (604 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
ENSPCOP00000005396Uncharacterized protein. (130 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
AREGAmphiregulin. (253 aa)
NOTCH1Notch receptor 1. (2420 aa)
TBX2T-box transcription factor 2. (713 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
CUL3Cullin 3; Belongs to the cullin family. (734 aa)
LAMA1Laminin subunit alpha 1. (2945 aa)
NOTCH2Notch receptor 2. (2471 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PLAG1PLAG1 zinc finger. (499 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ENSPCOP00000000775LIM zinc-binding domain-containing protein. (77 aa)
GLI3GLI family zinc finger 3. (1580 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
MSNMoesin. (577 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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