STRINGSTRING
MCM7 MCM7 ENSPCOP00000002776 ENSPCOP00000002776 MCM4 MCM4 GINS1 GINS1 POLA1 POLA1 POLE POLE RFC3 RFC3 RFC4 RFC4 LOC105824103 LOC105824103 DCLRE1B DCLRE1B POLD2 POLD2 POLD3 POLD3 ENSPCOP00000024841 ENSPCOP00000024841 ENSPCOP00000025432 ENSPCOP00000025432 LIG3 LIG3 DNA2 DNA2 LIG1 LIG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
ENSPCOP00000002776Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (330 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
GINS1GINS complex subunit 1. (196 aa)
POLA1DNA polymerase. (1442 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa)
RFC3Replication factor C subunit 3. (356 aa)
RFC4Replication factor C subunit 4. (365 aa)
LOC105824103Uncharacterized protein. (430 aa)
DCLRE1BDNA cross-link repair 1B. (529 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
POLD3DNA polymerase delta 3, accessory subunit. (359 aa)
ENSPCOP00000024841Uncharacterized protein. (84 aa)
ENSPCOP00000025432Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (747 aa)
LIG3DNA ligase. (966 aa)
DNA2Uncharacterized protein. (833 aa)
LIG1DNA ligase. (916 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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