STRINGSTRING
LGR5 LGR5 CTDNEP1 CTDNEP1 TMEM198 TMEM198 WNT5A WNT5A ENSPCOP00000007435 ENSPCOP00000007435 ENSPCOP00000007374 ENSPCOP00000007374 RSPO1 RSPO1 UBR5 UBR5 DIXDC1 DIXDC1 LGR6 LGR6 FGF9 FGF9 LRRK1 LRRK1 ASPM ASPM EDA EDA MLLT3 MLLT3 TTC21B TTC21B MBD2 MBD2 ENSPCOP00000004928 ENSPCOP00000004928 ENSPCOP00000004829 ENSPCOP00000004829 LEF1 LEF1 HHEX HHEX ENSPCOP00000002776 ENSPCOP00000002776 GPC3 GPC3 PPM1B PPM1B WNT10B WNT10B WNK1 WNK1 SULF1 SULF1 FGF10 FGF10 USP47 USP47 ENSPCOP00000000851 ENSPCOP00000000851 NRARP NRARP SOX4 SOX4 TRPM4 TRPM4 ATP6V0C ATP6V0C PTK7 PTK7 DAAM2 DAAM2 JUP JUP PIN1 PIN1 PRDM15 PRDM15 ATP6V1C2 ATP6V1C2 VPS35 VPS35 YAP1 YAP1 TMEM9 TMEM9 DKK2 DKK2 SULF2 SULF2 NLE1 NLE1 DEPDC1B DEPDC1B SMURF2 SMURF2 XIAP XIAP KANK1 KANK1 LOC105805276 LOC105805276 NFKB1 NFKB1 MACF1 MACF1 ENSPCOP00000030206 ENSPCOP00000030206 RSPO4 RSPO4 FGFR2 FGFR2 LGR4 LGR4 SFRP1 SFRP1 FAM53B FAM53B BMP2 BMP2 SALL1 SALL1 SKI SKI GSKIP GSKIP BAMBI BAMBI WNT5B WNT5B LOC105807749 LOC105807749 DACT1 DACT1 ABL1 ABL1 USP8 USP8 RNF146 RNF146 RNF220 RNF220 JRK JRK ENSPCOP00000026845 ENSPCOP00000026845 PBXIP1 PBXIP1 PLEKHA4 PLEKHA4 CDH3 CDH3 WNK2 WNK2 ENSPCOP00000025432 ENSPCOP00000025432 WNT3A WNT3A DLX5 DLX5 TBL1XR1 TBL1XR1 CAV1 CAV1 ENSPCOP00000025005 ENSPCOP00000025005 LRRK2 LRRK2 TNKS2 TNKS2 WNT3 WNT3 LYPD6 LYPD6 CAPRIN2 CAPRIN2 WLS WLS PPM1A PPM1A TGFB1 TGFB1 ENSPCOP00000022492 ENSPCOP00000022492 GPRC5B GPRC5B DAPK3 DAPK3 ARNTL ARNTL SMARCA4 SMARCA4 CCAR2 CCAR2 SMAD3 SMAD3 ATP6AP2 ATP6AP2 CDC73 CDC73 DAB2 DAB2 ZEB2 ZEB2 DKK1 DKK1 COL1A1 COL1A1 PPM1N PPM1N NKD1 NKD1 SFRP2 SFRP2 SRC SRC SCEL SCEL EGFR EGFR ENSPCOP00000018033 ENSPCOP00000018033 SFRP4 SFRP4 ANKRD6 ANKRD6 ENSPCOP00000016901 ENSPCOP00000016901 VCP VCP RECK RECK ZRANB1 ZRANB1 AMER1 AMER1 CCN4 CCN4 GID8 GID8 USP34 USP34 ADGRA2 ADGRA2 EGF EGF RUVBL1 RUVBL1 RSPO2 RSPO2 ENSPCOP00000013694 ENSPCOP00000013694 RPS12 RPS12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
TMEM198Transmembrane protein 198. (360 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSPCOP00000007435DUF4203 domain-containing protein. (348 aa)
ENSPCOP0000000737440S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (152 aa)
RSPO1R-spondin 1. (266 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2776 aa)
DIXDC1DIX domain containing 1. (683 aa)
LGR6Leucine rich repeat containing G protein-coupled receptor 6. (958 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LRRK1Leucine rich repeat kinase 1. (2012 aa)
ASPMAbnormal spindle microtubule assembly. (3472 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
MLLT3MLLT3 super elongation complex subunit. (569 aa)
TTC21BTetratricopeptide repeat domain 21B. (1163 aa)
MBD2Methyl-CpG binding domain protein 2. (410 aa)
ENSPCOP00000004928Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (258 aa)
ENSPCOP00000004829RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (71 aa)
LEF1Lymphoid enhancer binding factor 1. (432 aa)
HHEXHematopoietically expressed homeobox. (271 aa)
ENSPCOP00000002776Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (330 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
PPM1BPPM-type phosphatase domain-containing protein. (387 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNK1WNK lysine deficient protein kinase 1. (2808 aa)
SULF1Sulfatase 1. (863 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa)
ENSPCOP0000000085140S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (124 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
SOX4Transcription factor SOX. (479 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1204 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (154 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1072 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1077 aa)
JUPJunction plakoglobin. (745 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
PRDM15PR/SET domain 15. (1183 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (414 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
YAP1Uncharacterized protein. (504 aa)
TMEM9Transmembrane protein 9. (183 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
SULF2Sulfatase 2. (850 aa)
NLE1Notchless homolog 1. (485 aa)
DEPDC1BDEP domain containing 1B. (529 aa)
SMURF2SMAD specific E3 ubiquitin protein ligase 2. (602 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
KANK1KN motif and ankyrin repeat domains 1. (1350 aa)
LOC105805276Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
MACF1Microtubule actin crosslinking factor 1. (7591 aa)
ENSPCOP00000030206Ribosomal_L7Ae domain-containing protein. (124 aa)
RSPO4R-spondin 4. (233 aa)
FGFR2Fibroblast growth factor receptor. (797 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (920 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
FAM53BFamily with sequence similarity 53 member B. (424 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
SALL1Spalt like transcription factor 1. (1315 aa)
SKISKI proto-oncogene. (718 aa)
GSKIPGSK3B interacting protein. (139 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
LOC105807749RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (284 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (798 aa)
ABL1Tyrosine-protein kinase. (1146 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1068 aa)
RNF146Ring finger protein 146. (358 aa)
RNF220Ring finger protein 220. (566 aa)
JRKJrk helix-turn-helix protein. (550 aa)
ENSPCOP00000026845USP8_dimer domain-containing protein. (167 aa)
PBXIP1PBX homeobox interacting protein 1. (723 aa)
PLEKHA4Pleckstrin homology domain containing A4. (777 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (825 aa)
WNK2WNK lysine deficient protein kinase 2. (2211 aa)
ENSPCOP00000025432Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (747 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
DLX5Distal-less homeobox 5. (289 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (514 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
ENSPCOP00000025005Uncharacterized protein. (351 aa)
LRRK2Leucine rich repeat kinase 2. (2427 aa)
TNKS2Poly [ADP-ribose] polymerase. (1018 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LYPD6LY6/PLAUR domain containing 6. (171 aa)
CAPRIN2Caprin family member 2. (1069 aa)
WLSWnt ligand secretion mediator. (543 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ENSPCOP00000022492Uncharacterized protein. (356 aa)
GPRC5BG protein-coupled receptor class C group 5 member B. (404 aa)
DAPK3Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (626 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1661 aa)
CCAR2Cell cycle and apoptosis regulator 2. (922 aa)
SMAD3Mothers against decapentaplegic homolog. (443 aa)
ATP6AP2ATPase H+ transporting accessory protein 2. (273 aa)
CDC73Cell division cycle 73. (429 aa)
DAB2DAB adaptor protein 2. (769 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1258 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (268 aa)
COL1A1Collagen type I alpha 1 chain. (1461 aa)
PPM1NProtein phosphatase, Mg2+/Mn2+ dependent 1N (putative). (422 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (471 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
SRCTyrosine-protein kinase. (543 aa)
SCELSciellin. (630 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ENSPCOP00000018033HH_signal domain-containing protein. (110 aa)
SFRP4Secreted frizzled related protein 4. (342 aa)
ANKRD6Ankyrin repeat domain 6. (726 aa)
ENSPCOP0000001690140S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (126 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (969 aa)
ZRANB1Zinc finger RANBP2-type containing 1. (727 aa)
AMER1APC membrane recruitment protein 1. (796 aa)
CCN4Cellular communication network factor 4. (365 aa)
GID8GID complex subunit 8 homolog. (228 aa)
USP34Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (3561 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1314 aa)
EGFEpidermal growth factor. (1132 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (245 aa)
RSPO2R-spondin 2. (243 aa)
ENSPCOP00000013694Uncharacterized protein. (199 aa)
RPS1240S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (132 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
Server load: low (18%) [HD]