STRINGSTRING
SOST SOST EGR2 EGR2 LRP4 LRP4 TXLNG TXLNG SRGN SRGN BMP2 BMP2 SFRP1 SFRP1 SOX11 SOX11 DHRS3 DHRS3 P2RX7 P2RX7 MAPK1 MAPK1 PTPN11 PTPN11 SOX9 SOX9 ECM1 ECM1 IFITM5 IFITM5 BMP6 BMP6 BMP4 BMP4 OSR2 OSR2 PTK2B PTK2B S1PR1 S1PR1 ENSPCOP00000027736 ENSPCOP00000027736 KL KL PHOSPHO1 PHOSPHO1 OSR1 OSR1 SIX2 SIX2 RFLNA RFLNA CALCR CALCR TGFB1 TGFB1 PKDCC PKDCC RFLNB RFLNB COMP COMP SMAD3 SMAD3 PTGER4 PTGER4 WNT4 WNT4 TPH1 TPH1 ENPP1 ENPP1 BCOR BCOR BCL2 BCL2 DKK1 DKK1 MATN1 MATN1 NIPBL NIPBL CYP27B1 CYP27B1 GATA1 GATA1 LTBP3 LTBP3 PTN PTN DDR2 DDR2 TFAP2A TFAP2A LOC105816687 LOC105816687 CCN1 CCN1 FAM20C FAM20C MAPK14 MAPK14 BGLAP BGLAP ACVR1 ACVR1 KREMEN2 KREMEN2 ALOX5 ALOX5 BMPR2 BMPR2 BMPR1B BMPR1B AHSG AHSG ANO6 ANO6 VDR VDR SLC8A1 SLC8A1 TACR1 TACR1 MDK MDK ISG15 ISG15 BMPR1A BMPR1A FBN2 FBN2 BMP2K BMP2K ACTN3 ACTN3 ACVR2A ACVR2A INTU INTU ADGRV1 ADGRV1 GFRA4 GFRA4 ZMPSTE24 ZMPSTE24 KREMEN1 KREMEN1 GPM6B GPM6B GDF10 GDF10 LOC105819868 LOC105819868 MEF2C MEF2C NELL1 NELL1 MAPK3 MAPK3 WNT5A WNT5A RXRB RXRB OXT OXT ESRRA ESRRA TGFB3 TGFB3 ATRAID ATRAID ACVR2B ACVR2B RXRA RXRA CSF1 CSF1 TENT5A TENT5A CHSY1 CHSY1 NOTUM NOTUM LTF LTF TRPM4 TRPM4 SGMS2 SGMS2 SMAD7 SMAD7 TGFB2 TGFB2 SCUBE2 SCUBE2 ZBTB16 ZBTB16 ATP2B1 ATP2B1 WNT10B WNT10B SMAD6 SMAD6 OMD OMD BMP7 BMP7 ANKH ANKH NOTCH1 NOTCH1 HIF1A HIF1A FGF23 FGF23
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOSTSclerostin. (213 aa)
EGR2Early growth response 2. (473 aa)
LRP4LDL receptor related protein 4. (1922 aa)
TXLNGTaxilin gamma. (508 aa)
SRGNSerglycin. (153 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
SOX11Transcription factor SOX. (442 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SOX9SRY-box transcription factor 9. (505 aa)
ECM1Extracellular matrix protein 1. (570 aa)
IFITM5Interferon induced transmembrane protein 5. (134 aa)
BMP6Bone morphogenetic protein 6. (509 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (967 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
ENSPCOP00000027736G_PROTEIN_RECEP_F2_4 domain-containing protein. (334 aa)
KLKlotho. (988 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase. (267 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
SIX2SIX homeobox 2. (296 aa)
RFLNARefilin A. (208 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (479 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (492 aa)
RFLNBRefilin B. (146 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
SMAD3Mothers against decapentaplegic homolog. (443 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (925 aa)
BCORBCL6 corepressor. (1760 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (268 aa)
MATN1Matrilin 1. (499 aa)
NIPBLNipped-B protein. (2673 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
GATA1GATA binding protein 1. (413 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1306 aa)
PTNPleiotrophin. (177 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
LOC105816687Uncharacterized protein. (80 aa)
CCN1Cellular communication network factor 1. (381 aa)
FAM20CFAM20C golgi associated secretory pathway kinase. (584 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
BGLAPOsteocalcin; Binds strongly to apatite and calcium. (102 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
KREMEN2Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (460 aa)
ALOX5Arachidonate 5-lipoxygenase. (675 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (500 aa)
AHSGAlpha 2-HS glycoprotein. (364 aa)
ANO6Anoctamin. (932 aa)
VDRVitamin D receptor. (474 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (974 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
MDKMidkine. (143 aa)
ISG15ISG15 ubiquitin like modifier. (174 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (484 aa)
FBN2Fibrillin 2. (2912 aa)
BMP2KProtein kinase domain-containing protein. (616 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (936 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (416 aa)
INTUInturned planar cell polarity protein. (942 aa)
ADGRV1GPS domain-containing protein. (5403 aa)
GFRA4GDNF family receptor alpha 4. (259 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (458 aa)
GPM6BGlycoprotein M6B. (328 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
NELL1Neural EGFL like 1. (810 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
RXRBRetinoid X receptor beta. (535 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ATRAIDAll-trans retinoic acid induced differentiation factor. (229 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (529 aa)
RXRARetinoid X receptor alpha. (469 aa)
CSF1Colony stimulating factor 1. (438 aa)
TENT5ATerminal nucleotidyltransferase 5A. (513 aa)
CHSY1Hexosyltransferase. (804 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (499 aa)
LTFLactotransferrin; Belongs to the transferrin family. (708 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1204 aa)
SGMS2Sphingomyelin synthase 2. (366 aa)
SMAD7Mothers against decapentaplegic homolog. (490 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (994 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
SMAD6Mothers against decapentaplegic homolog. (500 aa)
OMDOsteomodulin. (422 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ANKHANKH inorganic pyrophosphate transport regulator. (452 aa)
NOTCH1Notch receptor 1. (2420 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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