(52 nodes) T-tubule network (Propithecus coquereli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AKAP6	A-kinase anchoring protein 6. (2315 aa)
	CACNA2D1	Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (740 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	ENSPCOP00000003784	Na_trans_assoc domain-containing protein. (129 aa)
	KCNJ11	Potassium voltage-gated channel subfamily J member 11. (390 aa)
	RTN2	Reticulon. (519 aa)
	CACNB3	Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
	ADRA1A	Adrenoceptor alpha 1A. (466 aa)
	SCN1B	Sodium voltage-gated channel beta subunit 1. (218 aa)
	STAC3	SH3 and cysteine rich domain 3. (364 aa)
	ATP1A2	Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
	ENSPCOP00000031717	Uncharacterized protein. (1612 aa)
	ENSPCOP00000031722	PDZ domain-containing protein. (158 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
	ENSPCOP00000014340	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (468 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1204 aa)
	CACNG7	Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
	SLC2A4	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2180 aa)
	VDR	Vitamin D receptor. (474 aa)
	SLC8A1	Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (974 aa)
	FER1L5	Fer-1 like family member 5. (2003 aa)
	STBD1	Starch binding domain 1. (351 aa)
	ATP1A1	Sodium/potassium-transporting ATPase subunit alpha. (1023 aa)
	ATP1B1	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
	CAPN3	Calpain 3; Belongs to the peptidase C2 family. (821 aa)
	BIN1	Bridging integrator 1. (594 aa)
	ASB3	Ankyrin repeat and SOCS box containing 3. (473 aa)
	NOS1AP	Nitric oxide synthase 1 adaptor protein. (507 aa)
	AHNAK2	Uncharacterized protein. (647 aa)
	CACNG6	Calcium voltage-gated channel auxiliary subunit gamma 6. (184 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	CACNG8	Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (419 aa)
	SCN5A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2017 aa)
	STAC	SH3 and cysteine rich domain. (402 aa)
	CASQ1	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (400 aa)
	ANK3	Ankyrin 3. (4372 aa)
	ANK2	Ankyrin 2. (3925 aa)
	CACNG1	Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (222 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2016 aa)
	CACNB2	Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
	CACNG4	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
	ENSPCOP00000019967	Uncharacterized protein. (713 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1544 aa)
	SCN1A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1741 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1350 aa)
	DYSF	Dysferlin. (2120 aa)
	KCNJ3	Potassium voltage-gated channel subfamily J member 3. (501 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (531 aa)
	FXYD1	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
	AQP4	Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
	ENSPCOP00000027819	Uncharacterized protein. (200 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHNAK2	DYSF	ENSPCOP00000009175	ENSPCOP00000022130	Uncharacterized protein.	Dysferlin.	0.415
AHNAK2	ENSPCOP00000031717	ENSPCOP00000009175	ENSPCOP00000031717	Uncharacterized protein.	Uncharacterized protein.	0.831
ANK2	CACNA1C	ENSPCOP00000016636	ENSPCOP00000017234	Ankyrin 2.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.411
ANK2	KCNJ11	ENSPCOP00000016636	ENSPCOP00000002973	Ankyrin 2.	Potassium voltage-gated channel subfamily J member 11.	0.445
ANK2	SCN5A	ENSPCOP00000016636	ENSPCOP00000006360	Ankyrin 2.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.594
ANK3	CACNA1C	ENSPCOP00000015809	ENSPCOP00000017234	Ankyrin 3.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.481
ANK3	ENSPCOP00000003784	ENSPCOP00000015809	ENSPCOP00000003784	Ankyrin 3.	Na_trans_assoc domain-containing protein.	0.526
ANK3	ENSPCOP00000014340	ENSPCOP00000015809	ENSPCOP00000014340	Ankyrin 3.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.526
ANK3	ENSPCOP00000019967	ENSPCOP00000015809	ENSPCOP00000019967	Ankyrin 3.	Uncharacterized protein.	0.526
ANK3	ENSPCOP00000027819	ENSPCOP00000015809	ENSPCOP00000027819	Ankyrin 3.	Uncharacterized protein.	0.526
ANK3	PPP3CB	ENSPCOP00000015809	ENSPCOP00000025321	Ankyrin 3.	Serine/threonine-protein phosphatase.	0.425
ANK3	SCN1A	ENSPCOP00000015809	ENSPCOP00000021531	Ankyrin 3.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.565
ANK3	SCN5A	ENSPCOP00000015809	ENSPCOP00000006360	Ankyrin 3.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.743
ATP1A1	ATP1B1	ENSPCOP00000012242	ENSPCOP00000012223	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.989
ATP1A1	CASQ1	ENSPCOP00000012242	ENSPCOP00000005654	Sodium/potassium-transporting ATPase subunit alpha.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.505
ATP1A1	FXYD1	ENSPCOP00000012242	ENSPCOP00000027189	Sodium/potassium-transporting ATPase subunit alpha.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.832
ATP1A1	SCN1A	ENSPCOP00000012242	ENSPCOP00000021531	Sodium/potassium-transporting ATPase subunit alpha.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.438
ATP1A1	SLC9A1	ENSPCOP00000012242	ENSPCOP00000031786	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.588
ATP1A2	ATP1B1	ENSPCOP00000031602	ENSPCOP00000012223	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.989
ATP1A2	CASQ1	ENSPCOP00000031602	ENSPCOP00000005654	Sodium/potassium-transporting ATPase subunit alpha.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.508