(54 nodes) Cortical cytoskeleton organization network (Propithecus coquereli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ARF6	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	EPB41L2	Erythrocyte membrane protein band 4.1 like 2. (998 aa)
	RAB13	Uncharacterized protein. (202 aa)
	PLEK	Pleckstrin. (350 aa)
	LCP1	Lymphocyte cytosolic protein 1. (620 aa)
	RHOBTB3	Rho related BTB domain containing 3. (548 aa)
	RTKN	Rhotekin. (564 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1316 aa)
	RHOBTB2	Rho related BTB domain containing 2. (727 aa)
	RAC2	Rac family small GTPase 2. (192 aa)
	FHOD3	Formin homology 2 domain containing 3. (1618 aa)
	ROCK2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1361 aa)
	FMNL3	Formin like 3. (1026 aa)
	RACGAP1	Rac GTPase activating protein 1. (632 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (910 aa)
	PPP2R3C	Protein phosphatase 2 regulatory subunit B''gamma. (410 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
	PDCD6IP	Programmed cell death 6 interacting protein. (873 aa)
	RHOBTB1	Rho related BTB domain containing 1. (697 aa)
	RAC1	Rac family small GTPase 1. (211 aa)
	RND2	Rho family GTPase 2. (227 aa)
	EPB41	Erythrocyte membrane protein band 4.1. (785 aa)
	LLGL1	LLGL scribble cell polarity complex component 1. (1065 aa)
	NCKAP1L	NCK associated protein 1 like. (1138 aa)
	RND1	Rho family GTPase 1. (232 aa)
	STRIP1	Striatin interacting protein 1. (879 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (747 aa)
	PLS1	Plastin 1. (630 aa)
	PLEC	Plectin. (4689 aa)
	ANLN	Anillin actin binding protein. (982 aa)
	EPB41L1	Erythrocyte membrane protein band 4.1 like 1. (881 aa)
	AKAP11	A-kinase anchoring protein 11. (1901 aa)
	WDR1	WD repeat domain 1. (606 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	RHOQ	Ras homolog family member Q. (205 aa)
	TLN1	Talin 1. (2548 aa)
	CALR	Calreticulin. (417 aa)
	TRPV4	Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
	RHOD	Ras homolog family member D. (210 aa)
	FMNL2	Formin like 2. (968 aa)
	FMNL1	Formin like 1. (1107 aa)
	CAVIN3	Caveolae associated protein 3. (286 aa)
	RHOG	Ras homolog family member G. (191 aa)
	EHD2	EH domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (543 aa)
	RHOF	Ras homolog family member F, filopodia associated. (211 aa)
	EPB41L3	Erythrocyte membrane protein band 4.1 like 3. (1096 aa)
	NLGN1	Neuroligin 1. (823 aa)
	NCKAP1	NCK associated protein 1. (1006 aa)
	VPS4A	Uncharacterized protein; Belongs to the AAA ATPase family. (504 aa)
	RAC3	Rac family small GTPase 3. (205 aa)
	RHOB	Ras homolog family member B. (196 aa)
	EZR	Ezrin. (586 aa)
	FHOD1	Formin homology 2 domain containing 1. (1157 aa)
	VIL1	Villin 1. (827 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANLN	ARF6	ENSPCOP00000023747	ENSPCOP00000000295	Anillin actin binding protein.	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	0.573
ANLN	RAC1	ENSPCOP00000023747	ENSPCOP00000017224	Anillin actin binding protein.	Rac family small GTPase 1.	0.721
ANLN	RAC2	ENSPCOP00000023747	ENSPCOP00000009590	Anillin actin binding protein.	Rac family small GTPase 2.	0.721
ANLN	RAC3	ENSPCOP00000023747	ENSPCOP00000001644	Anillin actin binding protein.	Rac family small GTPase 3.	0.721
ANLN	RACGAP1	ENSPCOP00000023747	ENSPCOP00000012691	Anillin actin binding protein.	Rac GTPase activating protein 1.	0.963
ANLN	RHOB	ENSPCOP00000023747	ENSPCOP00000001560	Anillin actin binding protein.	Ras homolog family member B.	0.909
ANLN	RHOBTB1	ENSPCOP00000023747	ENSPCOP00000015884	Anillin actin binding protein.	Rho related BTB domain containing 1.	0.770
ANLN	RHOBTB2	ENSPCOP00000023747	ENSPCOP00000009263	Anillin actin binding protein.	Rho related BTB domain containing 2.	0.770
ANLN	RHOBTB3	ENSPCOP00000023747	ENSPCOP00000006852	Anillin actin binding protein.	Rho related BTB domain containing 3.	0.709
ANLN	RHOD	ENSPCOP00000023747	ENSPCOP00000031514	Anillin actin binding protein.	Ras homolog family member D.	0.709
ANLN	RHOF	ENSPCOP00000023747	ENSPCOP00000003010	Anillin actin binding protein.	Ras homolog family member F, filopodia associated.	0.881
ANLN	RHOG	ENSPCOP00000023747	ENSPCOP00000003380	Anillin actin binding protein.	Ras homolog family member G.	0.717
ANLN	RHOQ	ENSPCOP00000023747	ENSPCOP00000026460	Anillin actin binding protein.	Ras homolog family member Q.	0.709
ANLN	RND1	ENSPCOP00000023747	ENSPCOP00000019207	Anillin actin binding protein.	Rho family GTPase 1.	0.897
ANLN	RND2	ENSPCOP00000023747	ENSPCOP00000017796	Anillin actin binding protein.	Rho family GTPase 2.	0.709
ANLN	ROCK1	ENSPCOP00000023747	ENSPCOP00000007812	Anillin actin binding protein.	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.715
ANLN	ROCK2	ENSPCOP00000023747	ENSPCOP00000011832	Anillin actin binding protein.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.715
ANLN	RTKN	ENSPCOP00000023747	ENSPCOP00000007521	Anillin actin binding protein.	Rhotekin.	0.668
ARF6	ANLN	ENSPCOP00000000295	ENSPCOP00000023747	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	Anillin actin binding protein.	0.573
ARF6	EHD2	ENSPCOP00000000295	ENSPCOP00000003323	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	EH domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.419