STRINGSTRING
WNT5A WNT5A IGFBP5 IGFBP5 GLI3 GLI3 APLN APLN FGF10 FGF10 TGFBR2 TGFBR2 ATP2C2 ATP2C2 MST1 MST1 FOXB1 FOXB1 TBX2 TBX2 APRT APRT LEF1 LEF1 HIF1A HIF1A AREG AREG MED1 MED1 ENSPCOP00000005396 ENSPCOP00000005396 SLC6A3 SLC6A3 NTN1 NTN1 STAT6 STAT6 CSF1 CSF1 TGFB3 TGFB3 LOC105822779 LOC105822779 TGFA TGFA SOSTDC1 SOSTDC1 NEURL1 NEURL1 GLI2 GLI2 NFKB1 NFKB1 XDH XDH RPLP0 RPLP0 TNFRSF11A TNFRSF11A SLC29A2 SLC29A2 NRG1 NRG1 ARHGAP35 ARHGAP35 FOXF1 FOXF1 PRLR PRLR EPHA2 EPHA2 FASN FASN GHRHR GHRHR MGMT MGMT CSMD1 CSMD1 HK2 HK2 VDR VDR BSX BSX LATS1 LATS1 KDM5B KDM5B EGF EGF IRF6 IRF6 PAM PAM USF2 USF2 DDR1 DDR1 PRL PRL HOXA5 HOXA5 BTRC BTRC ATP7B ATP7B SRC SRC CREB1 CREB1 ELF3 ELF3 AKT2 AKT2 CYP19A1 CYP19A1 NCOR2 NCOR2 PML PML NRG3 NRG3 GPAT4 GPAT4 SCRIB SCRIB TPH1 TPH1 WNT4 WNT4 AGAP2 AGAP2 STAT5A STAT5A ORAI1 ORAI1 PTCH1 PTCH1 ATP7A ATP7A TGFB1 TGFB1 ESR1 ESR1 VEGFA VEGFA WNT3 WNT3 ZNF703 ZNF703 BCL2L11 BCL2L11 CAV1 CAV1 ARHGAP5 ARHGAP5 WNT3A WNT3A STAT5B STAT5B PYGO2 PYGO2 CSN2 CSN2 ARG1 ARG1 CSF1R CSF1R CSMD2 CSMD2 ITGA2 ITGA2 ENSPCOP00000027781 ENSPCOP00000027781 PGR PGR SMO SMO BMP4 BMP4 CEBPB CEBPB HOXD9 HOXD9 SLC29A1 SLC29A1 LRP5 LRP5 HOXB9 HOXB9 AKT1 AKT1 NOTCH4 NOTCH4 ID2 ID2 SOX9 SOX9 CSN3 CSN3 ENSPCOP00000029403 ENSPCOP00000029403 CCND1 CCND1 MSX1 MSX1 MAPK1 MAPK1 LRRC1 LRRC1 FGFR2 FGFR2 WNT2 WNT2 TDGF1 TDGF1 IQGAP3 IQGAP3 TNFSF11 TNFSF11 ZBTB7B ZBTB7B AR AR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
GLI3GLI family zinc finger 3. (1580 aa)
APLNApelin. (77 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ATP2C2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (964 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
FOXB1Forkhead box B1. (325 aa)
TBX2T-box transcription factor 2. (713 aa)
APRTAdenine phosphoribosyltransferase. (183 aa)
LEF1Lymphoid enhancer binding factor 1. (432 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
AREGAmphiregulin. (253 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
ENSPCOP00000005396Uncharacterized protein. (130 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (619 aa)
NTN1Netrin 1. (604 aa)
STAT6Signal transducer and activator of transcription. (846 aa)
CSF1Colony stimulating factor 1. (438 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LOC105822779Uncharacterized protein. (325 aa)
TGFATransforming growth factor alpha. (190 aa)
SOSTDC1Sclerostin domain containing 1. (229 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
GLI2GLI family zinc finger 2. (1590 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
XDHXanthine dehydrogenase. (1313 aa)
RPLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (318 aa)
TNFRSF11ATNF receptor superfamily member 11a. (584 aa)
SLC29A2Solute carrier family 29 member 2. (457 aa)
NRG1Neuregulin 1. (710 aa)
ARHGAP35Rho GTPase activating protein 35. (1510 aa)
FOXF1Forkhead box F1. (381 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (523 aa)
EPHA2EPH receptor A2. (976 aa)
FASNFatty acid synthase. (2506 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
MGMTO-6-methylguanine-DNA methyltransferase. (241 aa)
CSMD1CUB and Sushi multiple domains 1. (3147 aa)
HK2Hexokinase 2. (841 aa)
VDRVitamin D receptor. (474 aa)
BSXBrain specific homeobox. (232 aa)
LATS1Large tumor suppressor kinase 1. (1131 aa)
KDM5BLysine demethylase 5B. (1544 aa)
EGFEpidermal growth factor. (1132 aa)
IRF6Interferon regulatory factor 6. (467 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (695 aa)
USF2Upstream transcription factor 2, c-fos interacting. (351 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (913 aa)
PRLProlactin. (231 aa)
HOXA5Homeobox A5. (270 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (609 aa)
ATP7BATPase copper transporting beta. (1460 aa)
SRCTyrosine-protein kinase. (543 aa)
CREB1cAMP responsive element binding protein 1. (280 aa)
ELF3E74 like ETS transcription factor 3. (372 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
NCOR2Nuclear receptor corepressor 2. (2486 aa)
PMLPromyelocytic leukemia. (887 aa)
NRG3Neuregulin 3. (721 aa)
GPAT4Glycerol-3-phosphate acyltransferase 4. (456 aa)
SCRIBScribble planar cell polarity protein. (1598 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1193 aa)
STAT5ASignal transducer and activator of transcription. (805 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (307 aa)
PTCH1Patched 1. (1449 aa)
ATP7AATPase copper transporting alpha. (1502 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (599 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
ZNF703Zinc finger protein 703. (589 aa)
BCL2L11BCL2 like 11. (200 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
ARHGAP5Rho GTPase activating protein 5. (1501 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
STAT5BSignal transducer and activator of transcription. (667 aa)
PYGO2Pygopus family PHD finger 2. (407 aa)
CSN2Casein beta. (182 aa)
ARG1Arginase. (229 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
CSMD2CUB and Sushi multiple domains 2. (3597 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1129 aa)
ENSPCOP00000027781Uncharacterized protein. (82 aa)
PGRNuclear receptor domain-containing protein. (592 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
HOXD9Homeobox D9. (357 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (456 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
HOXB9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NOTCH4Notch receptor 4. (2000 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
SOX9SRY-box transcription factor 9. (505 aa)
CSN3Casein kappa. (150 aa)
ENSPCOP00000029403Protein kinase domain-containing protein. (429 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
LRRC1Leucine rich repeat containing 1. (484 aa)
FGFR2Fibroblast growth factor receptor. (797 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
TDGF1Teratocarcinoma-derived growth factor 1. (186 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1607 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (320 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (572 aa)
ARAndrogen receptor. (886 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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