(54 nodes) Cytoplasmic microtubule organization network (Propithecus coquereli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CEP126	Centrosomal protein 126. (1036 aa)
	TUBGCP4	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (666 aa)
	FSD1	Fibronectin type III and SPRY domain containing 1. (496 aa)
	CEP120	Centrosomal protein 120. (936 aa)
	STMN3	Stathmin; Belongs to the stathmin family. (180 aa)
	IFT172	Intraflagellar transport 172. (1723 aa)
	FSD1L	Fibronectin type III and SPRY domain containing 1 like. (467 aa)
	TUBG1	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (451 aa)
	CLIP2	CAP-Gly domain containing linker protein 2. (1064 aa)
	CHP1	Calcineurin like EF-hand protein 1. (201 aa)
	DCTN1	CAP-Gly domain-containing protein. (1290 aa)
	CLASP1	Cytoplasmic linker associated protein 1. (1552 aa)
	TUBGCP3	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (907 aa)
	CCDC18	Coiled-coil domain containing 18. (1418 aa)
	KATNA1	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...] (437 aa)
	CLIP1	CAP-Gly domain containing linker protein 1. (1438 aa)
	FAM193B	Family with sequence similarity 193 member B. (821 aa)
	SLAIN2	SLAIN motif family member 2. (501 aa)
	KATNB1	Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Micr [...] (655 aa)
	DYNC1H1	Dynein cytoplasmic 1 heavy chain 1. (4637 aa)
	TPPP	Tubulin polymerization promoting protein. (210 aa)
	ENSPCOP00000009621	Uncharacterized protein. (500 aa)
	SLK	STE20 like kinase. (1241 aa)
	ENSPCOP00000009529	Asp-B-Hydro_N domain-containing protein. (270 aa)
	CCDC88B	Coiled-coil domain containing 88B. (1474 aa)
	CAMSAP2	Calmodulin regulated spectrin associated protein family member 2. (1364 aa)
	CIB1	Calcium and integrin binding 1. (191 aa)
	SLAIN1	SLAIN motif family member 1. (584 aa)
	ENSPCOP00000013871	Uncharacterized protein. (83 aa)
	TUBGCP6	Tubulin gamma complex associated protein 6. (1650 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	FAM193A	Family with sequence similarity 193 member A. (1494 aa)
	CCDC88A	Coiled-coil domain containing 88A. (1722 aa)
	CLIP4	CAP-Gly domain containing linker protein family member 4. (610 aa)
	EZR	Ezrin. (586 aa)
	WDR73	WD repeat domain 73. (373 aa)
	KIF19	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (994 aa)
	ENSPCOP00000000035	Uncharacterized protein. (103 aa)
	DST	Dystonin. (7002 aa)
	TRPV4	Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
	CCDC13	Uncharacterized protein. (714 aa)
	AXIN1	Axin 1. (865 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (910 aa)
	ENSPCOP00000015405	Uncharacterized protein. (113 aa)
	HOOK3	Hook microtubule tethering protein 3. (721 aa)
	CAMSAP3	Calmodulin regulated spectrin associated protein family member 3. (1212 aa)
	HOOK2	Hook microtubule tethering protein 2. (719 aa)
	TUBG2	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (464 aa)
	LIMK2	LIM domain kinase 2. (638 aa)
	CAMSAP1	Calmodulin regulated spectrin associated protein 1. (1594 aa)
	KPNB1	Karyopherin subunit beta 1. (876 aa)
	MAP10	Microtubule associated protein 10. (976 aa)
	DVL1	Dishevelled segment polarity protein 1. (722 aa)
	PCM1	Pericentriolar material 1. (1897 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN1	CAV3	ENSPCOP00000030142	ENSPCOP00000004480	Axin 1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.475
AXIN1	DVL1	ENSPCOP00000030142	ENSPCOP00000026920	Axin 1.	Dishevelled segment polarity protein 1.	0.989
CAMSAP1	DST	ENSPCOP00000027681	ENSPCOP00000031902	Calmodulin regulated spectrin associated protein 1.	Dystonin.	0.505
CAMSAP1	KATNB1	ENSPCOP00000027681	ENSPCOP00000011587	Calmodulin regulated spectrin associated protein 1.	Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Micr [...]	0.559
CAMSAP2	CAMSAP3	ENSPCOP00000008258	ENSPCOP00000030574	Calmodulin regulated spectrin associated protein family member 2.	Calmodulin regulated spectrin associated protein family member 3.	0.512
CAMSAP2	DST	ENSPCOP00000008258	ENSPCOP00000031902	Calmodulin regulated spectrin associated protein family member 2.	Dystonin.	0.454
CAMSAP2	KATNB1	ENSPCOP00000008258	ENSPCOP00000011587	Calmodulin regulated spectrin associated protein family member 2.	Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Micr [...]	0.452
CAMSAP3	CAMSAP2	ENSPCOP00000030574	ENSPCOP00000008258	Calmodulin regulated spectrin associated protein family member 3.	Calmodulin regulated spectrin associated protein family member 2.	0.512
CAMSAP3	DST	ENSPCOP00000030574	ENSPCOP00000031902	Calmodulin regulated spectrin associated protein family member 3.	Dystonin.	0.505
CAMSAP3	KATNB1	ENSPCOP00000030574	ENSPCOP00000011587	Calmodulin regulated spectrin associated protein family member 3.	Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Micr [...]	0.452
CAV3	AXIN1	ENSPCOP00000004480	ENSPCOP00000030142	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Axin 1.	0.475
CAV3	DLG1	ENSPCOP00000004480	ENSPCOP00000015085	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	0.655
CCDC13	CCDC18	ENSPCOP00000030391	ENSPCOP00000019067	Uncharacterized protein.	Coiled-coil domain containing 18.	0.570
CCDC13	CEP126	ENSPCOP00000030391	ENSPCOP00000024197	Uncharacterized protein.	Centrosomal protein 126.	0.465
CCDC18	CCDC13	ENSPCOP00000019067	ENSPCOP00000030391	Coiled-coil domain containing 18.	Uncharacterized protein.	0.570
CCDC18	CEP126	ENSPCOP00000019067	ENSPCOP00000024197	Coiled-coil domain containing 18.	Centrosomal protein 126.	0.463
CCDC88B	CHP1	ENSPCOP00000009399	ENSPCOP00000020286	Coiled-coil domain containing 88B.	Calcineurin like EF-hand protein 1.	0.561
CCDC88B	CIB1	ENSPCOP00000009399	ENSPCOP00000007404	Coiled-coil domain containing 88B.	Calcium and integrin binding 1.	0.561
CCDC88B	CLIP1	ENSPCOP00000009399	ENSPCOP00000018013	Coiled-coil domain containing 88B.	CAP-Gly domain containing linker protein 1.	0.417
CCDC88B	CLIP2	ENSPCOP00000009399	ENSPCOP00000020378	Coiled-coil domain containing 88B.	CAP-Gly domain containing linker protein 2.	0.417