STRINGSTRING
LOC105805691 LOC105805691 SUPT16H SUPT16H LOC105805653 LOC105805653 LOC105805676 LOC105805676 LOC105805703 LOC105805703 H1-5 H1-5 LOC105805693 LOC105805693 PADI6 PADI6 LOC105808155 LOC105808155 ENSPCOP00000001451 ENSPCOP00000001451 M1AP M1AP ENSPCOP00000001375 ENSPCOP00000001375 ENSPCOP00000001292 ENSPCOP00000001292 LOC105808154 LOC105808154 NAP1L3 NAP1L3 ENSPCOP00000000819 ENSPCOP00000000819 HMGA2 HMGA2 LOC105805701 LOC105805701 LOC105805688 LOC105805688 LOC105805690 LOC105805690 ZNFX1 ZNFX1 ASF1B ASF1B SMYD3 SMYD3 ATRX ATRX DAXX DAXX ENSPCOP00000015834 ENSPCOP00000015834 NOC2L NOC2L ENSPCOP00000015751 ENSPCOP00000015751 ZDBF2 ZDBF2 BRD2 BRD2 TNP1 TNP1 DNMT1 DNMT1 ENSPCOP00000013418 ENSPCOP00000013418 HIRA HIRA ENSPCOP00000013227 ENSPCOP00000013227 BAZ2A BAZ2A TSPYL2 TSPYL2 NASP NASP LOC105813758 LOC105813758 MCM2 MCM2 BEND3 BEND3 RB1 RB1 ITGB3BP ITGB3BP NAP1L4 NAP1L4 LOC105811124 LOC105811124 KAT6B KAT6B OIP5 OIP5 ENSPCOP00000009092 ENSPCOP00000009092 ANP32B ANP32B SHPRH SHPRH LMNB1 LMNB1 IPO4 IPO4 ENSPCOP00000007642 ENSPCOP00000007642 ENSPCOP00000006301 ENSPCOP00000006301 SART3 SART3 LOC105805697 LOC105805697 LOC105805726 LOC105805726 LOC105805692 LOC105805692 ENSPCOP00000005384 ENSPCOP00000005384 MACROH2A1 MACROH2A1 MBD2 MBD2 ENSPCOP00000005069 ENSPCOP00000005069 ENSPCOP00000004787 ENSPCOP00000004787 H1-4 H1-4 UBN2 UBN2 H2BC15 H2BC15 CHAF1B CHAF1B CTBP1 CTBP1 ENSPCOP00000004369 ENSPCOP00000004369 H1-10 H1-10 H2AX H2AX BAHD1 BAHD1 LOC105821917 LOC105821917 H2BC9 H2BC9 ENSPCOP00000003703 ENSPCOP00000003703 ENSPCOP00000003606 ENSPCOP00000003606 LOC105805647 LOC105805647 LOC105821920 LOC105821920 GRWD1 GRWD1 NRM NRM ENSPCOP00000002972 ENSPCOP00000002972 ENSPCOP00000002858 ENSPCOP00000002858 LOC105805699 LOC105805699 H2BC5 H2BC5 KMT2D KMT2D SSRP1 SSRP1 ENSPCOP00000021297 ENSPCOP00000021297 KAT6A KAT6A ENSPCOP00000021166 ENSPCOP00000021166 ENSPCOP00000021037 ENSPCOP00000021037 UBR2 UBR2 NAP1L1 NAP1L1 EZH2 EZH2 DNAJC9 DNAJC9 MBD3 MBD3 UBN1 UBN1 DOT1L DOT1L CHRAC1 CHRAC1 LOC105805686 LOC105805686 CDAN1 CDAN1 HAT1 HAT1 TSPYL1 TSPYL1 SPTY2D1 SPTY2D1 CENPV CENPV PADI4 PADI4 RSF1 RSF1 ENSPCOP00000022568 ENSPCOP00000022568 PPM1D PPM1D ENSPCOP00000022967 ENSPCOP00000022967 LOC105818918 LOC105818918 ENSPCOP00000023588 ENSPCOP00000023588 NAA60 NAA60 HELLS HELLS NPM1 NPM1 FAM172A FAM172A ENSPCOP00000023982 ENSPCOP00000023982 ENSPCOP00000024369 ENSPCOP00000024369 H1-8 H1-8 RRP8 RRP8 CENPP CENPP CENPW CENPW MACROH2A2 MACROH2A2 MECP2 MECP2 HDAC1 HDAC1 MIS18A MIS18A CHAF1A CHAF1A DNMT3A DNMT3A LOC105824205 LOC105824205 SET SET ASF1A ASF1A HP1BP3 HP1BP3 H2AJ H2AJ HJURP HJURP CTCF CTCF LOC105816693 LOC105816693 LOC105805725 LOC105805725 H3-4 H3-4 SIRT1 SIRT1 LOC105805675 LOC105805675 ENSPCOP00000028220 ENSPCOP00000028220 ENSPCOP00000028227 ENSPCOP00000028227 LOC105805698 LOC105805698 ENSPCOP00000028467 ENSPCOP00000028467 H2BC11 H2BC11 BAZ1A BAZ1A SOX9 SOX9 POLE3 POLE3 AXIN1 AXIN1 RIF1 RIF1 SMCHD1 SMCHD1 LMNA LMNA LMNB2 LMNB2 TP53 TP53 SIRT6 SIRT6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC105805691Histone H2B; Belongs to the histone H2B family. (132 aa)
SUPT16HSPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa)
LOC105805653Histone H3.1. (136 aa)
LOC105805676Histone H3.1. (136 aa)
LOC105805703Histone H2B; Belongs to the histone H2B family. (126 aa)
H1-5Histone cluster 1 H1 family member b. (226 aa)
LOC105805693Histone H2B; Belongs to the histone H2B family. (126 aa)
PADI6Peptidyl arginine deiminase 6. (660 aa)
LOC105808155Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSPCOP00000001451annotation not available (136 aa)
M1APMeiosis 1 associated protein. (530 aa)
ENSPCOP00000001375annotation not available (136 aa)
ENSPCOP00000001292annotation not available (136 aa)
LOC105808154Histone H2B; Belongs to the histone H2B family. (126 aa)
NAP1L3Nucleosome assembly protein 1 like 3; Belongs to the nucleosome assembly protein (NAP) family. (493 aa)
ENSPCOP00000000819annotation not available (136 aa)
HMGA2Uncharacterized protein. (117 aa)
LOC105805701Histone H3; Belongs to the histone H3 family. (136 aa)
LOC105805688Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105805690Histone H2B; Belongs to the histone H2B family. (126 aa)
ZNFX1Zinc finger NFX1-type containing 1. (1916 aa)
ASF1BAnti-silencing function 1B histone chaperone. (202 aa)
SMYD3SET and MYND domain containing 3. (428 aa)
ATRXATRX chromatin remodeler. (2447 aa)
DAXXDeath domain associated protein. (739 aa)
ENSPCOP00000015834Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (250 aa)
NOC2LNOC2 like nucleolar associated transcriptional repressor. (744 aa)
ENSPCOP00000015751Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (331 aa)
ZDBF2Zinc finger DBF-type containing 2. (2313 aa)
BRD2Uncharacterized protein. (799 aa)
TNP1Transition protein 1. (55 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1615 aa)
ENSPCOP00000013418Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (88 aa)
HIRAProtein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1017 aa)
ENSPCOP00000013227Uncharacterized protein. (169 aa)
BAZ2ABromodomain adjacent to zinc finger domain 2A. (1907 aa)
TSPYL2TSPY like 2; Belongs to the nucleosome assembly protein (NAP) family. (690 aa)
NASPNuclear autoantigenic sperm protein. (695 aa)
LOC105813758Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (345 aa)
MCM2DNA helicase; Belongs to the MCM family. (738 aa)
BEND3BEN domain containing 3. (828 aa)
RB1RB transcriptional corepressor 1. (787 aa)
ITGB3BPCentromere protein R; Transcription coregulator that can have both coactivator and corepressor functions. (177 aa)
NAP1L4Nucleosome assembly protein 1 like 4; Belongs to the nucleosome assembly protein (NAP) family. (386 aa)
LOC105811124Uncharacterized protein. (256 aa)
KAT6BHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2064 aa)
OIP5Opa interacting protein 5. (188 aa)
ENSPCOP00000009092E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (366 aa)
ANP32BAcidic nuclear phosphoprotein 32 family member B. (253 aa)
SHPRHSNF2 histone linker PHD RING helicase. (1208 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (583 aa)
IPO4Importin 4. (1080 aa)
ENSPCOP00000007642GFA domain-containing protein. (272 aa)
ENSPCOP00000006301Histone domain-containing protein; Belongs to the histone H2B family. (145 aa)
SART3Spliceosome associated factor 3, U4/U6 recycling protein. (902 aa)
LOC105805697Histone H4. (103 aa)
LOC105805726Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
LOC105805692Histone H2B type 1. (126 aa)
ENSPCOP00000005384annotation not available (103 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
MBD2Methyl-CpG binding domain protein 2. (410 aa)
ENSPCOP00000005069annotation not available (103 aa)
ENSPCOP00000004787Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (445 aa)
H1-4Histone cluster 1 H1 family member e. (219 aa)
UBN2Ubinuclein 2. (736 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (126 aa)
CHAF1BChromatin assembly factor 1 subunit B. (559 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (440 aa)
ENSPCOP00000004369Histone domain-containing protein. (136 aa)
H1-10H1 histone family member X. (202 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
BAHD1Bromo adjacent homology domain containing 1. (778 aa)
LOC105821917Histone H3; Belongs to the histone H3 family. (136 aa)
H2BC9Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSPCOP00000003703annotation not available (103 aa)
ENSPCOP00000003606annotation not available (136 aa)
LOC105805647Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105821920Histone H2B; Belongs to the histone H2B family. (126 aa)
GRWD1Glutamate rich WD repeat containing 1. (447 aa)
NRMNurim. (262 aa)
ENSPCOP00000002972annotation not available (103 aa)
ENSPCOP00000002858annotation not available (103 aa)
LOC105805699Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (131 aa)
KMT2DLysine methyltransferase 2D. (5467 aa)
SSRP1FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa)
ENSPCOP00000021297Uncharacterized protein; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (76 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2007 aa)
ENSPCOP00000021166GFA domain-containing protein. (282 aa)
ENSPCOP00000021037Uncharacterized protein. (446 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1482 aa)
NAP1L1Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (301 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
DNAJC9DnaJ heat shock protein family (Hsp40) member C9. (260 aa)
MBD3Methyl-CpG binding domain protein 3. (253 aa)
UBN1Ubinuclein 1. (1136 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1511 aa)
CHRAC1Chromatin accessibility complex subunit 1. (133 aa)
LOC105805686Histone H2B; Belongs to the histone H2B family. (126 aa)
CDAN1Codanin 1. (1232 aa)
HAT1Histone acetyltransferase 1. (394 aa)
TSPYL1TSPY like 1; Belongs to the nucleosome assembly protein (NAP) family. (385 aa)
SPTY2D1SPT2 chromatin protein domain containing 1. (684 aa)
CENPVCentromere protein V. (263 aa)
PADI4Peptidyl arginine deiminase 4. (628 aa)
RSF1Remodeling and spacing factor 1. (1424 aa)
ENSPCOP00000022568Uncharacterized protein; Belongs to the histone H2B family. (103 aa)
PPM1DProtein phosphatase, Mg2+/Mn2+ dependent 1D. (605 aa)
ENSPCOP00000022967Uncharacterized protein. (277 aa)
LOC105818918Uncharacterized protein. (757 aa)
ENSPCOP00000023588Uncharacterized protein. (206 aa)
NAA60N(alpha)-acetyltransferase 60, NatF catalytic subunit. (247 aa)
HELLSHelicase, lymphoid specific. (833 aa)
NPM1Uncharacterized protein. (294 aa)
FAM172AFamily with sequence similarity 172 member A. (284 aa)
ENSPCOP00000023982Chromo domain-containing protein. (156 aa)
ENSPCOP00000024369Uncharacterized protein; Belongs to the intermediate filament family. (156 aa)
H1-8H1 histone family member O oocyte specific. (299 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (454 aa)
CENPPCentromere protein P. (288 aa)
CENPWCentromere protein W. (88 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (500 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
MIS18AMIS18 kinetochore protein A. (232 aa)
CHAF1AChromatin assembly factor 1 subunit A. (959 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
LOC105824205Histone H2A; Belongs to the histone H2A family. (112 aa)
SETUncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (296 aa)
ASF1AAnti-silencing function 1A histone chaperone. (204 aa)
HP1BP3Heterochromatin protein 1 binding protein 3. (499 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
HJURPHolliday junction recognition protein. (738 aa)
CTCFCCCTC-binding factor. (727 aa)
LOC105816693Histone H4. (103 aa)
LOC105805725Histone H3.1. (136 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
SIRT1Sirtuin 1. (743 aa)
LOC105805675Histone H3.1. (136 aa)
ENSPCOP00000028220annotation not available (103 aa)
ENSPCOP00000028227annotation not available (103 aa)
LOC105805698Histone H4. (103 aa)
ENSPCOP00000028467Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
BAZ1AUncharacterized protein. (1366 aa)
SOX9SRY-box transcription factor 9. (505 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
AXIN1Axin 1. (865 aa)
RIF1Replication timing regulatory factor 1. (2476 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (1801 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (665 aa)
LMNB2Lamin B2; Belongs to the intermediate filament family. (620 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
SIRT6Sirtuin 6. (305 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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