STRINGSTRING
RECQL5 RECQL5 BLM BLM CHD6 CHD6 HELQ HELQ RPA1 RPA1 TM4SF19 TM4SF19 HELB HELB MCMDC2 MCMDC2 FBH1 FBH1 DHX36 DHX36 POT1 POT1 ENSPCOP00000004829 ENSPCOP00000004829 RTEL1 RTEL1 RECQL4 RECQL4 CHD7 CHD7 XRCC5 XRCC5 MCM7 MCM7 FANCM FANCM MCM5 MCM5 MCM4 MCM4 MCM3 MCM3 TWNK TWNK CHD8 CHD8 CHTF18 CHTF18 RAD51 RAD51 ENSPCOP00000008190 ENSPCOP00000008190 RAD54L RAD54L DSCC1 DSCC1 RAD54L2 RAD54L2 GINS1 GINS1 MCM9 MCM9 LOC105817821 LOC105817821 ERCC2 ERCC2 SLFNL1 SLFNL1 ASCC1 ASCC1 WRNIP1 WRNIP1 DDX11 DDX11 MCM2 MCM2 NAV2 NAV2 DHX9 DHX9 PIF1 PIF1 CHD4 CHD4 IGHMBP2 IGHMBP2 RUVBL1 RUVBL1 GINS2 GINS2 MCM6 MCM6 ATRX ATRX RFC3 RFC3 RFC4 RFC4 RFC5 RFC5 SMARCAD1 SMARCAD1 DERPC DERPC CHD3 CHD3 CHD1 CHD1 SUPV3L1 SUPV3L1 DQX1 DQX1 GINS3 GINS3 ENSPCOP00000020241 ENSPCOP00000020241 HMGA1 HMGA1 SETX SETX CHD5 CHD5 DHX32 DHX32 GTF2F2 GTF2F2 LOC105825324 LOC105825324 C17orf64 C17orf64 UPF1 UPF1 CHD1L CHD1L CDC45 CDC45 ERCC6L ERCC6L MCM8 MCM8 ENSPCOP00000024841 ENSPCOP00000024841 POLQ POLQ ERCC3 ERCC3 ENSPCOP00000027504 ENSPCOP00000027504 GINS4 GINS4 FSBP FSBP RUVBL2 RUVBL2 RFC2 RFC2 DNA2 DNA2 XRCC6 XRCC6 RECQL RECQL CHD2 CHD2 DDX1 DDX1 LOC105815151 LOC105815151 CHD9 CHD9 LOC105807749 LOC105807749 ASCC2 ASCC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (988 aa)
BLMBLM RecQ like helicase. (1352 aa)
CHD6Chromodomain helicase DNA binding protein 6. (2713 aa)
HELQHelicase, POLQ like. (914 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
TM4SF19Uncharacterized protein. (209 aa)
HELBDNA helicase B. (763 aa)
MCMDC2Minichromosome maintenance domain containing 2. (678 aa)
FBH1F-box DNA helicase 1. (1056 aa)
DHX36HA2 domain-containing protein. (718 aa)
POT1Protection of telomeres 1. (600 aa)
ENSPCOP00000004829RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (71 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1286 aa)
RECQL4RecQ like helicase 4. (842 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (677 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
FANCMFA complementation group M. (1953 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
MCM3DNA helicase; Belongs to the MCM family. (853 aa)
TWNKTwinkle mtDNA helicase. (669 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2592 aa)
CHTF18Chromosome transmission fidelity factor 18. (998 aa)
RAD51RAD51 recombinase; Belongs to the RecA family. (340 aa)
ENSPCOP00000008190AAA domain-containing protein. (331 aa)
RAD54LRAD54 like. (747 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (393 aa)
RAD54L2RAD54 like 2. (1466 aa)
GINS1GINS complex subunit 1. (196 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1103 aa)
LOC105817821X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (689 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (681 aa)
SLFNL1Schlafen like 1. (389 aa)
ASCC1Activating signal cointegrator 1 complex subunit 1. (357 aa)
WRNIP1WRN helicase interacting protein 1. (666 aa)
DDX11DEAD/H-box helicase 11. (835 aa)
MCM2DNA helicase; Belongs to the MCM family. (738 aa)
NAV2Neuron navigator 2. (2429 aa)
DHX9DExH-box helicase 9. (1262 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (643 aa)
CHD4Uncharacterized protein. (1899 aa)
IGHMBP2Immunoglobulin mu DNA binding protein 2. (979 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (245 aa)
GINS2GINS complex subunit 2. (151 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
ATRXATRX chromatin remodeler. (2447 aa)
RFC3Replication factor C subunit 3. (356 aa)
RFC4Replication factor C subunit 4. (365 aa)
RFC5AAA domain-containing protein. (338 aa)
SMARCAD1Helicase ATP-binding domain-containing protein. (842 aa)
DERPCDERPC proline and glycine rich nuclear protein. (529 aa)
CHD3Chromodomain helicase DNA binding protein 3. (2054 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1287 aa)
SUPV3L1Suv3 like RNA helicase. (667 aa)
DQX1DEAQ-box RNA dependent ATPase 1. (719 aa)
GINS3GINS complex subunit 3. (216 aa)
ENSPCOP00000020241Helicase C-terminal domain-containing protein. (607 aa)
HMGA1High mobility group AT-hook 1. (107 aa)
SETXSenataxin. (2676 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1954 aa)
DHX32DEAH-box helicase 32 (putative). (745 aa)
GTF2F2TFIIF_beta domain-containing protein. (124 aa)
LOC105825324Uncharacterized protein. (414 aa)
C17orf64Chromosome 17 open reading frame 64. (238 aa)
UPF1UPF1 RNA helicase and ATPase. (1129 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (831 aa)
CDC45Cell division cycle 45. (591 aa)
ERCC6LERCC excision repair 6 like, spindle assembly checkpoint helicase. (1251 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (822 aa)
ENSPCOP00000024841Uncharacterized protein. (84 aa)
POLQDNA polymerase theta. (2280 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
ENSPCOP00000027504DEAD domain-containing protein. (414 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (222 aa)
FSBPUncharacterized protein. (911 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (397 aa)
RFC2Replication factor C subunit 2. (352 aa)
DNA2Uncharacterized protein. (833 aa)
XRCC6X-ray repair cross complementing 6. (496 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (581 aa)
CHD2Uncharacterized protein. (1834 aa)
DDX1DEAD-box helicase 1. (723 aa)
LOC105815151Uncharacterized protein. (913 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2859 aa)
LOC105807749RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (284 aa)
ASCC2Activating signal cointegrator 1 complex subunit 2. (756 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.