STRINGSTRING
RAPGEF3 RAPGEF3 LOC105819920 LOC105819920 RAMP3 RAMP3 CSF3 CSF3 BAG4 BAG4 AXIN1 AXIN1 HDAC6 HDAC6 PARK7 PARK7 AKT1 AKT1 PDCD10 PDCD10 EIF4G1 EIF4G1 CNOT9 CNOT9 NTRK3 NTRK3 SPRY2 SPRY2 CD44 CD44 TFRC TFRC WNT3A WNT3A CAV1 CAV1 PINK1 PINK1 RIPK2 RIPK2 BRAF BRAF VEGFA VEGFA RET RET CAPRIN2 CAPRIN2 CALCR CALCR MIF MIF TGFB1 TGFB1 NTF3 NTF3 MAPKAP1 MAPKAP1 ANGPT1 ANGPT1 BCAR3 BCAR3 BCL2 BCL2 IFNG IFNG AKAP9 AKAP9 NOS1 NOS1 AVP AVP SFRP2 SFRP2 SH2D3C SH2D3C EGFR EGFR TBK1 TBK1 TNKS1BP1 TNKS1BP1 SMYD3 SMYD3 ENSPCOP00000015642 ENSPCOP00000015642 PIK3CA PIK3CA TNF TNF MTCP1 MTCP1 STK4 STK4 ATP2B4 ATP2B4 SH2D3A SH2D3A OPRD1 OPRD1 PRKD2 PRKD2 LATS1 LATS1 FNIP2 FNIP2 GSK3A GSK3A NRXN1 NRXN1 STOX1 STOX1 TCL1A TCL1A TENM1 TENM1 APP APP ARAF ARAF GCG GCG RPTOR RPTOR PTGS2 PTGS2 MAD2L2 MAD2L2 IL6 IL6 DOCK7 DOCK7 WNT5A WNT5A IFNE IFNE PAK1 PAK1 ERCC6 ERCC6 HAX1 HAX1 LOC105825287 LOC105825287 CAMK1 CAMK1 PRKD1 PRKD1 BDNF BDNF NTRK2 NTRK2 OSM OSM GAS6 GAS6 LIF LIF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
LOC105819920Uncharacterized protein. (116 aa)
RAMP3Receptor activity modifying protein 3. (151 aa)
CSF3Colony stimulating factor 3. (199 aa)
BAG4BCL2 associated athanogene 4. (457 aa)
AXIN1Axin 1. (865 aa)
HDAC6Histone deacetylase 6. (1203 aa)
PARK7DJ-1_PfpI domain-containing protein. (155 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PDCD10Programmed cell death 10. (186 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1605 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (330 aa)
NTRK3Tyrosine-protein kinase receptor. (865 aa)
SPRY2Sprouty RTK signaling antagonist 2. (314 aa)
CD44CD44 molecule (Indian blood group). (746 aa)
TFRCTransferrin receptor. (760 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
PINK1PTEN induced kinase 1. (581 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (539 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1079 aa)
CAPRIN2Caprin family member 2. (1069 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (479 aa)
MIFUncharacterized protein. (115 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
MAPKAP1MAPK associated protein 1. (492 aa)
ANGPT1Angiopoietin 1. (408 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (823 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
AKAP9A-kinase anchoring protein 9. (3687 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1434 aa)
AVPArginine vasopressin. (116 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
SH2D3CSH2 domain containing 3C. (860 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
TBK1TANK binding kinase 1. (690 aa)
TNKS1BP1Tankyrase 1 binding protein 1. (1726 aa)
SMYD3SET and MYND domain containing 3. (428 aa)
ENSPCOP00000015642DJ-1_PfpI domain-containing protein. (175 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
MTCP1Mature T cell proliferation 1. (107 aa)
STK4Serine/threonine kinase 4. (487 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1204 aa)
SH2D3ASH2 domain containing 3A. (577 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
LATS1Large tumor suppressor kinase 1. (1131 aa)
FNIP2Folliculin interacting protein 2. (1114 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
NRXN1Neurexin 1. (1449 aa)
STOX1Storkhead box 1. (980 aa)
TCL1AT cell leukemia/lymphoma 1A. (111 aa)
TENM1Teneurin transmembrane protein 1. (2732 aa)
APPAmyloid beta precursor protein. (772 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (609 aa)
GCGGlucagon. (180 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1281 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (235 aa)
IL6Uncharacterized protein. (211 aa)
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2000 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
IFNEInterferon epsilon. (178 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1488 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (278 aa)
LOC105825287DJ-1_PfpI domain-containing protein. (189 aa)
CAMK1Calcium/calmodulin dependent protein kinase I. (326 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (860 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
OSMOncostatin M. (251 aa)
GAS6Growth arrest specific 6. (648 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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