(18 nodes) Node of Ranvier network (Propithecus coquereli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KCNQ2	Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. (872 aa)
	ENSPCOP00000003784	Na_trans_assoc domain-containing protein. (129 aa)
	SPTBN4	Spectrin beta chain; Belongs to the spectrin family. (2533 aa)
	SPOCK1	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1. (377 aa)
	MYOC	Myocilin. (504 aa)
	KCNQ3	Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family. (807 aa)
	DAG1	Dystroglycan 1. (895 aa)
	CNTN2	Contactin 2. (1040 aa)
	SCN1A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1741 aa)
	ENSPCOP00000019967	Uncharacterized protein. (713 aa)
	HAPLN2	Hyaluronan and proteoglycan link protein 2. (341 aa)
	ANK3	Ankyrin 3. (4372 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (910 aa)
	ENSPCOP00000014340	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (468 aa)
	SCN8A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1995 aa)
	BIN1	Bridging integrator 1. (594 aa)
	NFASC	Neurofascin. (1237 aa)
	ENSPCOP00000027819	Uncharacterized protein. (200 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANK3	CNTN2	ENSPCOP00000015809	ENSPCOP00000022084	Ankyrin 3.	Contactin 2.	0.648
ANK3	DLG1	ENSPCOP00000015809	ENSPCOP00000015085	Ankyrin 3.	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	0.415
ANK3	ENSPCOP00000003784	ENSPCOP00000015809	ENSPCOP00000003784	Ankyrin 3.	Na_trans_assoc domain-containing protein.	0.526
ANK3	ENSPCOP00000014340	ENSPCOP00000015809	ENSPCOP00000014340	Ankyrin 3.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.526
ANK3	ENSPCOP00000019967	ENSPCOP00000015809	ENSPCOP00000019967	Ankyrin 3.	Uncharacterized protein.	0.526
ANK3	ENSPCOP00000027819	ENSPCOP00000015809	ENSPCOP00000027819	Ankyrin 3.	Uncharacterized protein.	0.526
ANK3	KCNQ2	ENSPCOP00000015809	ENSPCOP00000004953	Ankyrin 3.	Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family.	0.684
ANK3	KCNQ3	ENSPCOP00000015809	ENSPCOP00000024446	Ankyrin 3.	Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family.	0.656
ANK3	NFASC	ENSPCOP00000015809	ENSPCOP00000010767	Ankyrin 3.	Neurofascin.	0.893
ANK3	SCN1A	ENSPCOP00000015809	ENSPCOP00000021531	Ankyrin 3.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.565
ANK3	SCN8A	ENSPCOP00000015809	ENSPCOP00000013893	Ankyrin 3.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.731
ANK3	SPTBN4	ENSPCOP00000015809	ENSPCOP00000002884	Ankyrin 3.	Spectrin beta chain; Belongs to the spectrin family.	0.977
CNTN2	ANK3	ENSPCOP00000022084	ENSPCOP00000015809	Contactin 2.	Ankyrin 3.	0.648
CNTN2	NFASC	ENSPCOP00000022084	ENSPCOP00000010767	Contactin 2.	Neurofascin.	0.911
DAG1	NFASC	ENSPCOP00000023536	ENSPCOP00000010767	Dystroglycan 1.	Neurofascin.	0.463
DLG1	ANK3	ENSPCOP00000015085	ENSPCOP00000015809	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	Ankyrin 3.	0.415
DLG1	SPTBN4	ENSPCOP00000015085	ENSPCOP00000002884	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	Spectrin beta chain; Belongs to the spectrin family.	0.448
ENSPCOP00000003784	ANK3	ENSPCOP00000003784	ENSPCOP00000015809	Na_trans_assoc domain-containing protein.	Ankyrin 3.	0.526
ENSPCOP00000003784	ENSPCOP00000014340	ENSPCOP00000003784	ENSPCOP00000014340	Na_trans_assoc domain-containing protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.663
ENSPCOP00000003784	ENSPCOP00000019967	ENSPCOP00000003784	ENSPCOP00000019967	Na_trans_assoc domain-containing protein.	Uncharacterized protein.	0.763