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TEP1 TEP1 POLB POLB DKC1 DKC1 DNTT DNTT POLE2 POLE2 POLK POLK POLN POLN POLE POLE POLD1 POLD1 POLL POLL ARID3A ARID3A ENSPCOP00000002776 ENSPCOP00000002776 POLM POLM TENT4B TENT4B POLH POLH POLE4 POLE4 POLA1 POLA1 HAUS3 HAUS3 CHRAC1 CHRAC1 POLG POLG REV3L REV3L POLI POLI POLD4 POLD4 POLG2 POLG2 POLQ POLQ ENSPCOP00000025432 ENSPCOP00000025432
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TEP1Telomerase associated protein 1. (2562 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (333 aa)
DKC1Dyskerin pseudouridine synthase 1. (514 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (511 aa)
POLE2DNA polymerase epsilon 2, accessory subunit. (439 aa)
POLKDNA polymerase kappa. (832 aa)
POLNDNA polymerase nu. (899 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa)
POLD1DNA polymerase. (1125 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (573 aa)
ARID3AAT-rich interaction domain 3A. (605 aa)
ENSPCOP00000002776Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (330 aa)
POLMDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (491 aa)
TENT4BTerminal nucleotidyltransferase 4B. (607 aa)
POLHDNA polymerase eta. (709 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (118 aa)
POLA1DNA polymerase. (1442 aa)
HAUS3HAUS augmin like complex subunit 3. (601 aa)
CHRAC1Chromatin accessibility complex subunit 1. (133 aa)
POLGDNA polymerase gamma, catalytic subunit. (1224 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3120 aa)
POLIDNA polymerase iota. (735 aa)
POLD4Uncharacterized protein. (107 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (465 aa)
POLQDNA polymerase theta. (2280 aa)
ENSPCOP00000025432Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (747 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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