node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHRAC1 | POLA1 | ENSPCOP00000018944 | ENSPCOP00000012099 | Chromatin accessibility complex subunit 1. | DNA polymerase. | 0.550 |
CHRAC1 | POLD1 | ENSPCOP00000018944 | ENSPCOP00000015021 | Chromatin accessibility complex subunit 1. | DNA polymerase. | 0.550 |
CHRAC1 | POLE | ENSPCOP00000018944 | ENSPCOP00000014601 | Chromatin accessibility complex subunit 1. | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.803 |
CHRAC1 | POLE2 | ENSPCOP00000018944 | ENSPCOP00000029196 | Chromatin accessibility complex subunit 1. | DNA polymerase epsilon 2, accessory subunit. | 0.795 |
CHRAC1 | REV3L | ENSPCOP00000018944 | ENSPCOP00000014412 | Chromatin accessibility complex subunit 1. | REV3 like, DNA directed polymerase zeta catalytic subunit. | 0.550 |
DKC1 | ENSPCOP00000002776 | ENSPCOP00000028469 | ENSPCOP00000002776 | Dyskerin pseudouridine synthase 1. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.910 |
DKC1 | ENSPCOP00000025432 | ENSPCOP00000028469 | ENSPCOP00000025432 | Dyskerin pseudouridine synthase 1. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.910 |
DKC1 | TEP1 | ENSPCOP00000028469 | ENSPCOP00000026097 | Dyskerin pseudouridine synthase 1. | Telomerase associated protein 1. | 0.554 |
DNTT | POLA1 | ENSPCOP00000028932 | ENSPCOP00000012099 | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. | DNA polymerase. | 0.561 |
DNTT | POLB | ENSPCOP00000028932 | ENSPCOP00000027052 | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.730 |
DNTT | POLD1 | ENSPCOP00000028932 | ENSPCOP00000015021 | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. | DNA polymerase. | 0.712 |
DNTT | POLE | ENSPCOP00000028932 | ENSPCOP00000014601 | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.660 |
DNTT | POLE2 | ENSPCOP00000028932 | ENSPCOP00000029196 | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. | DNA polymerase epsilon 2, accessory subunit. | 0.520 |
DNTT | POLE4 | ENSPCOP00000028932 | ENSPCOP00000011084 | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. | DNA polymerase epsilon 4, accessory subunit. | 0.466 |
DNTT | POLL | ENSPCOP00000028932 | ENSPCOP00000015178 | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.702 |
DNTT | REV3L | ENSPCOP00000028932 | ENSPCOP00000014412 | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. | REV3 like, DNA directed polymerase zeta catalytic subunit. | 0.682 |
ENSPCOP00000002776 | DKC1 | ENSPCOP00000002776 | ENSPCOP00000028469 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Dyskerin pseudouridine synthase 1. | 0.910 |
ENSPCOP00000002776 | ENSPCOP00000025432 | ENSPCOP00000002776 | ENSPCOP00000025432 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.942 |
ENSPCOP00000002776 | TEP1 | ENSPCOP00000002776 | ENSPCOP00000026097 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Telomerase associated protein 1. | 0.700 |
ENSPCOP00000025432 | DKC1 | ENSPCOP00000025432 | ENSPCOP00000028469 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Dyskerin pseudouridine synthase 1. | 0.910 |