STRINGSTRING
RNF112 RNF112 TRPM2 TRPM2 FOS FOS RELA RELA RPS3 RPS3 RIPK3 RIPK3 ENSPCOP00000030811 ENSPCOP00000030811 TNFAIP3 TNFAIP3 MAPK13 MAPK13 MAPK1 MAPK1 HDAC6 HDAC6 CHUK CHUK BTK BTK PARK7 PARK7 ECT2 ECT2 AKT1 AKT1 MAP1LC3A MAP1LC3A PLEKHA1 PLEKHA1 PDCD10 PDCD10 MAPK8 MAPK8 PCGF2 PCGF2 ERCC6L2 ERCC6L2 SIRT1 SIRT1 TRPA1 TRPA1 ENSPCOP00000027398 ENSPCOP00000027398 PRKCD PRKCD ARG1 ARG1 KLF2 KLF2 ENSPCOP00000024882 ENSPCOP00000024882 RIPK1 RIPK1 KDM6B KDM6B PDK2 PDK2 PPARGC1B PPARGC1B AXL AXL ANKZF1 ANKZF1 ERN1 ERN1 ATP7A ATP7A STK25 STK25 CYP1B1 CYP1B1 MAPK10 MAPK10 ENSPCOP00000021800 ENSPCOP00000021800 PJVK PJVK AMBP AMBP IL18BP IL18BP PRDX5 PRDX5 SETX SETX AGAP3 AGAP3 ENSPCOP00000020030 ENSPCOP00000020030 EZH2 EZH2 NME8 NME8 NQO1 NQO1 ZNF277 ZNF277 SRC SRC SIGMAR1 SIGMAR1 EGFR EGFR UCP1 UCP1 MPO MPO MAP3K5 MAP3K5 MAPK7 MAPK7 ENSPCOP00000015642 ENSPCOP00000015642 SOD1 SOD1 PAX2 PAX2 PKD2 PKD2 BNIP3 BNIP3 PPIF PPIF MPV17 MPV17 LOC105818026 LOC105818026 FER FER HSF1 HSF1 SLC8A1 SLC8A1 PRDX1 PRDX1 CRYGD CRYGD MMP9 MMP9 OSER1 OSER1 SPHK1 SPHK1 CCS CCS NOS3 NOS3 AQP1 AQP1 IMPACT IMPACT FYN FYN MAPK3 MAPK3 IL6 IL6 ADPRHL2 ADPRHL2 MMP2 MMP2 FXN FXN NCF1 NCF1 SOD2 SOD2 EDN1 EDN1 FANCC FANCC STAT6 STAT6 SMPD3 SMPD3 NET1 NET1 ROMO1 ROMO1 FABP1 FABP1 ZNF580 ZNF580 LOC105825287 LOC105825287 ENSPCOP00000004143 ENSPCOP00000004143 MT3 MT3 AIFM1 AIFM1 NFE2L2 NFE2L2 CAMKK2 CAMKK2 MAPK9 MAPK9 RHOB RHOB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RNF112Ring finger protein 112. (632 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1539 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (516 aa)
ENSPCOP00000030811Sod_Cu domain-containing protein. (132 aa)
TNFAIP3TNF alpha induced protein 3. (792 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
HDAC6Histone deacetylase 6. (1203 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (682 aa)
BTKTyrosine-protein kinase. (647 aa)
PARK7DJ-1_PfpI domain-containing protein. (155 aa)
ECT2Epithelial cell transforming 2. (598 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (121 aa)
PLEKHA1Pleckstrin homology domain containing A1. (400 aa)
PDCD10Programmed cell death 10. (186 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
ERCC6L2ERCC excision repair 6 like 2. (672 aa)
SIRT1Sirtuin 1. (743 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1091 aa)
ENSPCOP00000027398KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (281 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
ARG1Arginase. (229 aa)
KLF2Kruppel like factor 2. (356 aa)
ENSPCOP00000024882Ribosomal_S3_C domain-containing protein. (231 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (643 aa)
KDM6BLysine demethylase 6B. (1653 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
PPARGC1BPPARG coactivator 1 beta. (1010 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
ANKZF1Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1. (722 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (935 aa)
ATP7AATPase copper transporting alpha. (1502 aa)
STK25Serine/threonine kinase 25. (426 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
ENSPCOP00000021800Uncharacterized protein. (175 aa)
PJVKPejvakin. (352 aa)
AMBPAlpha-1-microglobulin/bikunin precursor. (351 aa)
IL18BPInterleukin 18 binding protein. (196 aa)
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (225 aa)
SETXSenataxin. (2676 aa)
AGAP3ArfGAP with GTPase domain, ankyrin repeat and PH domain 3. (907 aa)
ENSPCOP00000020030KH type-2 domain-containing protein. (93 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
NME8NME/NM23 family member 8. (490 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (270 aa)
ZNF277Zinc finger protein 277. (456 aa)
SRCTyrosine-protein kinase. (543 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (223 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (306 aa)
MPOMyeloperoxidase. (742 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1317 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (802 aa)
ENSPCOP00000015642DJ-1_PfpI domain-containing protein. (175 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
PAX2Paired box 2. (417 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (963 aa)
BNIP3Uncharacterized protein. (235 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
MPV17Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (176 aa)
LOC105818026Thioredoxin domain-containing protein. (194 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
HSF1Heat shock transcription factor 1. (531 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (974 aa)
PRDX1Thioredoxin domain-containing protein. (199 aa)
CRYGDUncharacterized protein; Belongs to the beta/gamma-crystallin family. (174 aa)
MMP9Matrix metallopeptidase 9. (709 aa)
OSER1Oxidative stress responsive serine rich 1. (258 aa)
SPHK1Sphingosine kinase 1. (469 aa)
CCSCopper chaperone for superoxide dismutase. (274 aa)
NOS3Nitric oxide synthase 3. (994 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
IMPACTImpact RWD domain protein. (319 aa)
FYNTyrosine-protein kinase. (537 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
IL6Uncharacterized protein. (211 aa)
ADPRHL2ADP-ribosylhydrolase like 2. (365 aa)
MMP2Matrix metallopeptidase 2. (552 aa)
FXNFrataxin. (211 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
EDN1Endothelin 1. (193 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (563 aa)
STAT6Signal transducer and activator of transcription. (846 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
NET1Neuroepithelial cell transforming 1. (532 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
FABP1FABP domain-containing protein. (69 aa)
ZNF580Zinc finger protein 580. (172 aa)
LOC105825287DJ-1_PfpI domain-containing protein. (189 aa)
ENSPCOP00000004143Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (136 aa)
MT3Metallothionein 3; Belongs to the metallothionein superfamily. Type 1 family. (114 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (587 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
RHOBRas homolog family member B. (196 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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