STRINGSTRING
DPP7 DPP7 VEGFD VEGFD HPSE HPSE PYCARD PYCARD ITIH4 ITIH4 LRG1 LRG1 SRGN SRGN GSDMD GSDMD HUWE1 HUWE1 ENSPCOP00000030477 ENSPCOP00000030477 IGF2 IGF2 MAPK1 MAPK1 PSMD7 PSMD7 TRAPPC1 TRAPPC1 SPTAN1 SPTAN1 XRCC6 XRCC6 PSMB7 PSMB7 HRG HRG ECM1 ECM1 ERP44 ERP44 COMMD9 COMMD9 PCYOX1L PCYOX1L AGL AGL IMPDH2 IMPDH2 FOLR2 FOLR2 GHRL GHRL TOLLIP TOLLIP KPNB1 KPNB1 SDCBP SDCBP BIN2 BIN2 DBNL DBNL PSMA2 PSMA2 TCN1 TCN1 COTL1 COTL1 PRKCD PRKCD HK3 HK3 ELANE ELANE NAPRT NAPRT CRISPLD2 CRISPLD2 ARG1 ARG1 VWF VWF C1orf35 C1orf35 ACLY ACLY RETN RETN PTX3 PTX3 GIP GIP PSMD13 PSMD13 CRISP3 CRISP3 PSMA5 PSMA5 FAM49B FAM49B PDGFA PDGFA THBS1 THBS1 CTSZ CTSZ PLAC8 PLAC8 ARSB ARSB FGA FGA VPS13A VPS13A TGFB1 TGFB1 GGH GGH GYG1 GYG1 CTSA CTSA ACTR10 ACTR10 GLA GLA DBH DBH PNP PNP LOC105826870 LOC105826870 DSN1 DSN1 DNASE1L1 DNASE1L1 VEGFC VEGFC GMFG GMFG F8 F8 CHIT1 CHIT1 LOC105815346 LOC105815346 ORM1 ORM1 PENK PENK EPX EPX ENSPCOP00000020108 ENSPCOP00000020108 TXNDC5 TXNDC5 PSMD3 PSMD3 PRDX4 PRDX4 ATG7 ATG7 SERPING1 SERPING1 LRRC7 LRRC7 ACAA1 ACAA1 FGR FGR HGF HGF PSMD11 PSMD11 PSMC3 PSMC3 CFD CFD SLPI SLPI AMPD3 AMPD3 APAF1 APAF1 CRACR2A CRACR2A BPI BPI F13A1 F13A1 VCP VCP PSMD14 PSMD14 CEP290 CEP290 ARHGAP9 ARHGAP9 SPARC SPARC GSN GSN PYGL PYGL MPO MPO FAM3C FAM3C VAT1 VAT1 AZU1 AZU1 S100A9 S100A9 DNAJC3 DNAJC3 EGF EGF GMFB GMFB ENSPCOP00000014061 ENSPCOP00000014061 PTPN6 PTPN6 PCSK1 PCSK1 FGG FGG A1BG A1BG TIMP2 TIMP2 C3 C3 HEXB HEXB PSMD6 PSMD6 IMPDH1 IMPDH1 MMRN1 MMRN1 PSMB1 PSMB1 JUP JUP CDA CDA OLFM4 OLFM4 FAF2 FAF2 GALNS GALNS NHLRC2 NHLRC2 CANT1 CANT1 SERPINE1 SERPINE1 DYNC1H1 DYNC1H1 NEU1 NEU1 S100A12 S100A12 VTI1B VTI1B FRK FRK GCG GCG CREG1 CREG1 SERPINI1 SERPINI1 ARSA ARSA GNS GNS LOC105817821 LOC105817821 CTSG CTSG SCG3 SCG3 CTSW CTSW RAB27A RAB27A VEGFB VEGFB PA2G4 PA2G4 AOC1 AOC1 HEBP2 HEBP2 PDXK PDXK NFKB1 NFKB1 FOLR3 FOLR3 PRSS57 PRSS57 DYNLT1 DYNLT1 ACTR1B ACTR1B FGB FGB PADI2 PADI2 CYFIP1 CYFIP1 TEX264 TEX264 CLEC3B CLEC3B S100A11 S100A11 DERA DERA TGFB3 TGFB3 FABP5 FABP5 VCL VCL OSCAR OSCAR HSPA6 HSPA6 CAB39 CAB39 XRCC5 XRCC5 LCN2 LCN2 LTF LTF ALAD ALAD GTPBP2 GTPBP2 OSTF1 OSTF1 QPCT QPCT STK11IP STK11IP KNG1 KNG1 PDGFB PDGFB CLU CLU SPP2 SPP2 S100P S100P S100Z S100Z GRN GRN TGFB2 TGFB2 CTSH CTSH SERPINB1 SERPINB1 MMP8 MMP8 SERPINF2 SERPINF2 GRP GRP S100A8 S100A8 SPACA7 SPACA7 GAS6 GAS6 FERMT3 FERMT3 ENSPCOP00000000109 ENSPCOP00000000109 ENSPCOP00000000094 ENSPCOP00000000094
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DPP7Dipeptidyl peptidase 7. (489 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (319 aa)
HPSEHeparanase. (395 aa)
PYCARDPYD and CARD domain containing. (195 aa)
ITIH4Inter-alpha-trypsin inhibitor heavy chain 4. (901 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
SRGNSerglycin. (153 aa)
GSDMDGasdermin D. (545 aa)
HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4387 aa)
ENSPCOP00000030477PDZ domain-containing protein. (263 aa)
IGF2Insulin like growth factor 2. (236 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
TRAPPC1Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (145 aa)
SPTAN1Spectrin alpha, non-erythrocytic 1. (2498 aa)
XRCC6X-ray repair cross complementing 6. (496 aa)
PSMB7Proteasome subunit beta. (277 aa)
HRGHistidine rich glycoprotein. (468 aa)
ECM1Extracellular matrix protein 1. (570 aa)
ERP44Endoplasmic reticulum protein 44. (380 aa)
COMMD9COMM domain containing 9. (198 aa)
PCYOX1LPrenylcysteine oxidase 1 like. (494 aa)
AGLAmylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase. (1434 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
FOLR2Folate receptor beta. (251 aa)
GHRLGhrelin and obestatin prepropeptide. (116 aa)
TOLLIPToll interacting protein. (275 aa)
KPNB1Karyopherin subunit beta 1. (876 aa)
SDCBPUncharacterized protein. (298 aa)
BIN2Bridging integrator 2. (603 aa)
DBNLDrebrin like. (431 aa)
PSMA2Proteasome subunit alpha type. (245 aa)
TCN1Transcobalamin 1. (341 aa)
COTL1Coactosin like F-actin binding protein 1. (142 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
HK3Hexokinase 3. (924 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (268 aa)
NAPRTNicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (538 aa)
CRISPLD2Cysteine rich secretory protein LCCL domain containing 2. (497 aa)
ARG1Arginase. (229 aa)
VWFVon Willebrand factor. (2807 aa)
C1orf35Chromosome 1 open reading frame 35. (261 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1110 aa)
RETNResistin. (85 aa)
PTX3Pentraxin 3. (382 aa)
GIPGastric inhibitory polypeptide. (150 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (377 aa)
CRISP3Cysteine rich secretory protein 3. (239 aa)
PSMA5Proteasome subunit alpha type. (128 aa)
FAM49BFamily with sequence similarity 49 member B. (324 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
THBS1Thrombospondin 1. (1185 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (302 aa)
PLAC8Uncharacterized protein. (58 aa)
ARSBArylsulfatase B. (531 aa)
FGAFib_alpha domain-containing protein. (649 aa)
VPS13AVacuolar protein sorting 13 homolog A. (3014 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GGHFolate gamma-glutamyl hydrolase. (318 aa)
GYG1Glycogenin 1. (350 aa)
CTSACarboxypeptidase; Belongs to the peptidase S10 family. (494 aa)
ACTR10Actin related protein 10; Belongs to the actin family. (358 aa)
GLAAlpha-galactosidase. (428 aa)
DBHDopamine beta-hydroxylase. (620 aa)
PNPPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
LOC105826870Uncharacterized protein. (244 aa)
DSN1DSN1 component of MIS12 kinetochore complex. (349 aa)
DNASE1L1Deoxyribonuclease; Belongs to the DNase I family. (306 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (367 aa)
GMFGGlia maturation factor gamma. (80 aa)
F8Coagulation factor VIII; Belongs to the multicopper oxidase family. (2348 aa)
CHIT1Chitinase 1; Belongs to the glycosyl hydrolase 18 family. (466 aa)
LOC105815346Pr_beta_C domain-containing protein. (270 aa)
ORM1Lipocln_cytosolic_FA-bd_dom domain-containing protein. (200 aa)
PENKProenkephalin. (267 aa)
EPXEosinophil peroxidase. (714 aa)
ENSPCOP00000020108C-type lectin domain-containing protein. (120 aa)
TXNDC5Thioredoxin domain containing 5; Belongs to the protein disulfide isomerase family. (423 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
PRDX4Peroxiredoxin 4. (272 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (704 aa)
SERPING1Serpin family G member 1; Belongs to the serpin family. (491 aa)
LRRC7Leucine rich repeat containing 7. (1489 aa)
ACAA1Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
FGRTyrosine-protein kinase. (495 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (703 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
CFDComplement factor D; Belongs to the peptidase S1 family. (258 aa)
SLPISecretory leukocyte peptidase inhibitor. (132 aa)
AMPD3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (776 aa)
APAF1Apoptotic peptidase activating factor 1. (1204 aa)
CRACR2ACalcium release activated channel regulator 2A. (729 aa)
BPIBactericidal permeability increasing protein. (487 aa)
F13A1Coagulation factor XIII A chain. (732 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (274 aa)
CEP290Centrosomal protein 290. (2107 aa)
ARHGAP9Rho GTPase activating protein 9. (820 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
GSNGelsolin. (778 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (851 aa)
MPOMyeloperoxidase. (742 aa)
FAM3CFamily with sequence similarity 3 member C. (227 aa)
VAT1Vesicle amine transport 1. (391 aa)
AZU1Azurocidin 1. (250 aa)
S100A9S100 calcium binding protein A9; Belongs to the S-100 family. (154 aa)
DNAJC3DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
EGFEpidermal growth factor. (1132 aa)
GMFBGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (142 aa)
ENSPCOP00000014061Peptidase S1 domain-containing protein. (113 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (607 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (753 aa)
FGGFibrinogen gamma chain. (456 aa)
A1BGAlpha-1-B glycoprotein. (519 aa)
TIMP2TIMP metallopeptidase inhibitor 2. (220 aa)
C3Complement C3. (1551 aa)
HEXBBeta-hexosaminidase. (526 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (440 aa)
IMPDH1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (629 aa)
MMRN1Multimerin 1. (1222 aa)
PSMB1Proteasome subunit beta 1. (232 aa)
JUPJunction plakoglobin. (745 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
OLFM4Olfactomedin 4. (498 aa)
FAF2Fas associated factor family member 2. (448 aa)
GALNSGalactosamine (N-acetyl)-6-sulfatase. (517 aa)
NHLRC2NHL repeat containing 2. (707 aa)
CANT1Calcium activated nucleotidase 1. (401 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4637 aa)
NEU1Neuraminidase 1. (416 aa)
S100A12Protein S100; Belongs to the S-100 family. (92 aa)
VTI1BVesicle transport through interaction with t-SNAREs 1B. (232 aa)
FRKTyrosine-protein kinase. (508 aa)
GCGGlucagon. (180 aa)
CREG1Cellular repressor of E1A stimulated genes 1. (177 aa)
SERPINI1Serpin family I member 1; Belongs to the serpin family. (410 aa)
ARSAArylsulfatase A. (423 aa)
GNSN-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (533 aa)
LOC105817821X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (689 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (246 aa)
SCG3Secretogranin III. (340 aa)
CTSWCathepsin W; Belongs to the peptidase C1 family. (374 aa)
RAB27ARAB27A, member RAS oncogene family. (221 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
PA2G4Proliferation-associated 2G4. (394 aa)
AOC1Amine oxidase. (755 aa)
HEBP2Heme binding protein 2. (205 aa)
PDXKPyridoxal kinase. (312 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
FOLR3Folate receptor gamma. (249 aa)
PRSS57Serine protease 57; Belongs to the peptidase S1 family. (283 aa)
DYNLT1Dynein light chain Tctex-type 1. (113 aa)
ACTR1BActin related protein 1B. (376 aa)
FGBFibrinogen beta chain. (492 aa)
PADI2Peptidyl arginine deiminase 2. (614 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1244 aa)
TEX264Testis expressed 264, ER-phagy receptor. (313 aa)
CLEC3BC-type lectin domain family 3 member B. (202 aa)
S100A11Protein S100; Belongs to the S-100 family. (105 aa)
DERADeoxyribose-phosphate aldolase. (318 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FABP5Fatty acid binding protein 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
VCLVinculin. (1134 aa)
OSCAROsteoclast associated Ig-like receptor. (266 aa)
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (643 aa)
CAB39Calcium binding protein 39. (341 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (677 aa)
LCN2Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family. (197 aa)
LTFLactotransferrin; Belongs to the transferrin family. (708 aa)
ALADDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (327 aa)
GTPBP2GTP binding protein 2. (602 aa)
OSTF1Osteoclast stimulating factor 1. (214 aa)
QPCTGlutaminyl-peptide cyclotransferase. (332 aa)
STK11IPSerine/threonine kinase 11 interacting protein. (939 aa)
KNG1Uncharacterized protein. (391 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (450 aa)
SPP2Secreted phosphoprotein 2. (211 aa)
S100PS100 calcium binding protein P. (94 aa)
S100ZProtein S100; Belongs to the S-100 family. (99 aa)
GRNGranulin precursor. (591 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (336 aa)
SERPINB1Serpin family B member 1; Belongs to the serpin family. (379 aa)
MMP8Matrix metallopeptidase 8. (466 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (487 aa)
GRPGastrin releasing peptide. (137 aa)
S100A8S100 calcium binding protein A8; Belongs to the S-100 family. (89 aa)
SPACA7Sperm acrosome associated 7. (188 aa)
GAS6Growth arrest specific 6. (648 aa)
FERMT3Fermitin family member 3. (662 aa)
ENSPCOP00000000109Protein S100; Belongs to the S-100 family. (101 aa)
ENSPCOP00000000094Uncharacterized protein. (117 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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