STRINGSTRING
SP8 SP8 HAND2 HAND2 WNT7A WNT7A IHH IHH TBX4 TBX4 ZBTB16 ZBTB16 ECE1 ECE1 TGFB2 TGFB2 GRHL2 GRHL2 FGF10 FGF10 NOG NOG WNT7B WNT7B SOX4 SOX4 GLI3 GLI3 COL3A1 COL3A1 PBX2 PBX2 TFAP2A TFAP2A PITX1 PITX1 FBXW4 FBXW4 WDPCP WDPCP GNA12 GNA12 SFRP2 SFRP2 CPLANE1 CPLANE1 WDR19 WDR19 ZIC3 ZIC3 EXT1 EXT1 GDF5 GDF5 FRAS1 FRAS1 BAX BAX NIPBL NIPBL HOXD12 HOXD12 RDH10 RDH10 DKK1 DKK1 EVX2 EVX2 CREBBP CREBBP ASPH ASPH IFT140 IFT140 FLVCR1 FLVCR1 PTCH1 PTCH1 RARB RARB CTNNB1 CTNNB1 MBNL1 MBNL1 PKDCC PKDCC ZNF358 ZNF358 HOXD10 HOXD10 HNF1A HNF1A WNT3 WNT3 BCL2L11 BCL2L11 ZNF219 ZNF219 SMAD4 SMAD4 HDAC1 HDAC1 DLX5 DLX5 OSR1 OSR1 ENSPCOP00000025710 ENSPCOP00000025710 ALDH1A2 ALDH1A2 CHST11 CHST11 GAS1 GAS1 OSR2 OSR2 BMP4 BMP4 HOXD9 HOXD9 LMBR1 LMBR1 MAP3K20 MAP3K20 SOX9 SOX9 ENSPCOP00000018033 ENSPCOP00000018033 IQCE IQCE MSX1 MSX1 ENSPCOP00000030256 ENSPCOP00000030256 SOX11 SOX11 ACD ACD FGFR2 FGFR2 B9D1 B9D1 MKS1 MKS1 SALL1 SALL1 SKI SKI TP63 TP63 FGF4 FGF4 EN1 EN1 LRP4 LRP4 IMPAD1 IMPAD1 SHOX2 SHOX2 CRABP2 CRABP2 ALX3 ALX3 COL2A1 COL2A1 CACNA1C CACNA1C BAK1 BAK1 RECK RECK HOXA13 HOXA13 ATRX ATRX TFAP2B TFAP2B FZD6 FZD6 RARG RARG HOXA11 HOXA11 ENSPCOP00000014764 ENSPCOP00000014764 PSEN1 PSEN1 SP9 SP9 HOXD13 HOXD13 DLX6 DLX6 RSPO2 RSPO2 TULP3 TULP3 FGF8 FGF8 C2CD3 C2CD3 RNF165 RNF165 TBX5 TBX5 BMPR1A BMPR1A FBN2 FBN2 HOXC10 HOXC10 IFT52 IFT52 AFF3 AFF3 INTU INTU PCSK5 PCSK5 ALX4 ALX4 SALL4 SALL4 TMEM107 TMEM107 RPGRIP1L RPGRIP1L HOXA10 HOXA10 WNT5A WNT5A HOXC11 HOXC11 PRRX1 PRRX1 CYP26B1 CYP26B1 FGF9 FGF9 CHD7 CHD7 ENSPCOP00000005396 ENSPCOP00000005396 MED1 MED1 MYH3 MYH3 ENSPCOP00000004787 ENSPCOP00000004787 NOTCH1 NOTCH1 PLXNA2 PLXNA2 LEF1 LEF1 FREM2 FREM2 TBX2 TBX2 MEGF8 MEGF8 BMP7 BMP7 NOTCH2 NOTCH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SP8Sp8 transcription factor. (506 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (190 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
TBX4T-box transcription factor 4. (545 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
ECE1Endothelin converting enzyme 1. (758 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
SOX4Transcription factor SOX. (479 aa)
GLI3GLI family zinc finger 3. (1580 aa)
COL3A1Collagen type III alpha 1 chain. (1371 aa)
PBX2PBX homeobox 2. (430 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
PITX1Homeobox protein. (272 aa)
FBXW4F-box and WD repeat domain containing 4. (408 aa)
WDPCPWD repeat containing planar cell polarity effector. (720 aa)
GNA12G protein subunit alpha 12. (380 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3130 aa)
WDR19WD repeat domain 19. (1342 aa)
ZIC3Zic family member 3. (466 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
GDF5Growth differentiation factor 5. (499 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (3561 aa)
BAXBCL2 associated X, apoptosis regulator. (199 aa)
NIPBLNipped-B protein. (2673 aa)
HOXD12Homeobox D12. (270 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (268 aa)
EVX2Even-skipped homeobox 2. (474 aa)
CREBBPCREB binding protein. (2449 aa)
ASPHAspartate beta-hydroxylase. (687 aa)
IFT140Intraflagellar transport 140. (1458 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (488 aa)
PTCH1Patched 1. (1449 aa)
RARBRetinoic acid receptor beta. (448 aa)
CTNNB1Catenin beta 1. (781 aa)
MBNL1Muscleblind like splicing regulator 1. (347 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (492 aa)
ZNF358Zinc finger protein 358. (564 aa)
HOXD10Homeobox D10. (340 aa)
HNF1AHNF1 homeobox A. (662 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
BCL2L11BCL2 like 11. (200 aa)
ZNF219Zinc finger protein 219. (716 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
DLX5Distal-less homeobox 5. (289 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
ENSPCOP00000025710AAA_9 domain-containing protein. (83 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
GAS1Growth arrest specific 1. (340 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
HOXD9Homeobox D9. (357 aa)
LMBR1Limb development membrane protein 1; Belongs to the LIMR family. (466 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
SOX9SRY-box transcription factor 9. (505 aa)
ENSPCOP00000018033HH_signal domain-containing protein. (110 aa)
IQCEIQ motif containing E. (697 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
ENSPCOP00000030256DHC_N1 domain-containing protein. (571 aa)
SOX11Transcription factor SOX. (442 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (513 aa)
FGFR2Fibroblast growth factor receptor. (797 aa)
B9D1B9 domain containing 1. (204 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
SALL1Spalt like transcription factor 1. (1315 aa)
SKISKI proto-oncogene. (718 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
EN1Homeobox protein engrailed-like. (395 aa)
LRP4LDL receptor related protein 4. (1922 aa)
IMPAD1Inositol monophosphatase domain containing 1. (359 aa)
SHOX2Short stature homeobox 2. (355 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
ALX3ALX homeobox 3. (343 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2016 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (969 aa)
HOXA13Homeobox A13. (366 aa)
ATRXATRX chromatin remodeler. (2447 aa)
TFAP2BTranscription factor AP-2 beta. (460 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
RARGRetinoic acid receptor gamma. (458 aa)
HOXA11Homeobox A11. (316 aa)
ENSPCOP00000014764Uncharacterized protein. (428 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
SP9Sp9 transcription factor. (487 aa)
HOXD13Homeobox D13. (347 aa)
DLX6Distal-less homeobox 6. (288 aa)
RSPO2R-spondin 2. (243 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (461 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
C2CD3C2 domain containing 3 centriole elongation regulator. (2335 aa)
RNF165Ring finger protein 165. (347 aa)
TBX5T-box transcription factor 5. (518 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (484 aa)
FBN2Fibrillin 2. (2912 aa)
HOXC10Homeobox C10. (342 aa)
IFT52ABC_transp_aux domain-containing protein. (437 aa)
AFF3AF4/FMR2 family member 3. (1249 aa)
INTUInturned planar cell polarity protein. (942 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1858 aa)
ALX4ALX homeobox 4. (404 aa)
SALL4Spalt like transcription factor 4. (1052 aa)
TMEM107Transmembrane protein 107. (140 aa)
RPGRIP1LRPGRIP1 like. (1172 aa)
HOXA10Homeobox A10. (410 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
HOXC11Homeobox C11. (369 aa)
PRRX1Paired related homeobox 1. (245 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
ENSPCOP00000005396Uncharacterized protein. (130 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
MYH3Myosin heavy chain 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1925 aa)
ENSPCOP00000004787Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (445 aa)
NOTCH1Notch receptor 1. (2420 aa)
PLXNA2Plexin A2. (1909 aa)
LEF1Lymphoid enhancer binding factor 1. (432 aa)
FREM2FRAS1 related extracellular matrix 2. (3024 aa)
TBX2T-box transcription factor 2. (713 aa)
MEGF8Multiple EGF like domains 8. (2804 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
NOTCH2Notch receptor 2. (2471 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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