STRINGSTRING
PKP2 PKP2 GJC1 GJC1 KCNMB3 KCNMB3 DMRT3 DMRT3 CNTNAP1 CNTNAP1 CACNG5 CACNG5 P2RX4 P2RX4 SPTBN4 SPTBN4 ENSPCOP00000003181 ENSPCOP00000003181 CHRNB4 CHRNB4 ENSPCOP00000003784 ENSPCOP00000003784 ENSPCOP00000004143 ENSPCOP00000004143 DRD5 DRD5 SCN11A SCN11A NUP155 NUP155 CACNA2D1 CACNA2D1 HCN4 HCN4 MYH14 MYH14 SCN5A SCN5A SCN4A SCN4A CACNG8 CACNG8 DSP DSP ENSPCOP00000008247 ENSPCOP00000008247 KCND2 KCND2 ENSPCOP00000009091 ENSPCOP00000009091 ZMPSTE24 ZMPSTE24 PMP22 PMP22 RYR2 RYR2 NFASC NFASC BIN1 BIN1 SCN2B SCN2B TBX5 TBX5 KCNJ5 KCNJ5 JUP JUP SLC8A1 SLC8A1 ISL1 ISL1 CACNA1D CACNA1D CACNG2 CACNG2 SCN8A SCN8A CACNG7 CACNG7 SLC4A3 SLC4A3 ENSPCOP00000014340 ENSPCOP00000014340 SCN9A SCN9A CLDN19 CLDN19 NRCAM NRCAM P2RX1 P2RX1 KCNMB4 KCNMB4 SOD1 SOD1 CACNA1I CACNA1I ANK3 ANK3 MAG MAG ANK2 ANK2 RNF207 RNF207 CXADR CXADR KCNQ1 KCNQ1 CACNA1C CACNA1C CACNA1G CACNA1G CHRNA1 CHRNA1 CACNB2 CACNB2 HCN2 HCN2 CACNG4 CACNG4 ATP1A3 ATP1A3 KCNMB2 KCNMB2 JAM3 JAM3 HCN3 HCN3 AKAP9 AKAP9 ENSPCOP00000019967 ENSPCOP00000019967 SCN4B SCN4B SCN7A SCN7A MEF2A MEF2A SCN1A SCN1A CAMK2D CAMK2D GJD2 GJD2 CTNNA3 CTNNA3 PLEC PLEC DSG2 DSG2 KCNJ3 KCNJ3 YWHAE YWHAE KCNE4 KCNE4 CACNB4 CACNB4 CACNA1H CACNA1H CAV1 CAV1 GLRA1 GLRA1 P2RX3 P2RX3 DRD1 DRD1 KCNN2 KCNN2 KCNH2 KCNH2 S1PR1 S1PR1 ENSPCOP00000027819 ENSPCOP00000027819 GJA1 GJA1 SCN1B SCN1B SCN3A SCN3A P2RX7 P2RX7 TNNI3K TNNI3K ENSPCOP00000030811 ENSPCOP00000030811 KCNH6 KCNH6 SCN10A SCN10A SLC9A1 SLC9A1 OTOA OTOA ATP1B2 ATP1B2 NTRK2 NTRK2 MTOR MTOR TRPM4 TRPM4 RGS21 RGS21 CLCN1 CLCN1 GPR88 GPR88
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PKP2Plakophilin 2. (838 aa)
GJC1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (277 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (474 aa)
CNTNAP1Contactin associated protein 1. (1382 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (402 aa)
SPTBN4Spectrin beta chain; Belongs to the spectrin family. (2533 aa)
ENSPCOP00000003181PBPe domain-containing protein. (242 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (471 aa)
ENSPCOP00000003784Na_trans_assoc domain-containing protein. (129 aa)
ENSPCOP00000004143Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (136 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (434 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1773 aa)
NUP155Nucleoporin 155. (1218 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (740 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1199 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1995 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2017 aa)
SCN4ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1829 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (419 aa)
DSPDesmoplakin. (2868 aa)
ENSPCOP00000008247Uncharacterized protein. (164 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (574 aa)
ENSPCOP00000009091Uncharacterized protein. (291 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
RYR2Ryanodine receptor 2. (4825 aa)
NFASCNeurofascin. (1237 aa)
BIN1Bridging integrator 1. (594 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (215 aa)
TBX5T-box transcription factor 5. (518 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
JUPJunction plakoglobin. (745 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (974 aa)
ISL1ISL LIM homeobox 1. (349 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2180 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1995 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
SLC4A3Anion exchange protein. (1233 aa)
ENSPCOP00000014340Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (468 aa)
SCN9ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1852 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
NRCAMNeuronal cell adhesion molecule. (1304 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (1991 aa)
ANK3Ankyrin 3. (4372 aa)
MAGMyelin associated glycoprotein. (626 aa)
ANK2Ankyrin 2. (3925 aa)
RNF207Ring finger protein 207. (634 aa)
CXADRUncharacterized protein. (352 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (545 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2016 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2381 aa)
CHRNA1Cholinergic receptor nicotinic alpha 1 subunit. (479 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (816 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1080 aa)
KCNMB2KcnmB2_inactiv domain-containing protein. (235 aa)
JAM3Junctional adhesion molecule 3. (310 aa)
HCN3Hyperpolarization activated cyclic nucleotide gated potassium channel 3. (779 aa)
AKAP9A-kinase anchoring protein 9. (3687 aa)
ENSPCOP00000019967Uncharacterized protein. (713 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (225 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1448 aa)
MEF2AMyocyte enhancer factor 2A. (495 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1741 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (503 aa)
GJD2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (321 aa)
CTNNA3Catenin alpha 3. (783 aa)
PLECPlectin. (4689 aa)
DSG2Desmoglein 2. (1029 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (209 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2221 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (840 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1148 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
ENSPCOP00000027819Uncharacterized protein. (200 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (218 aa)
SCN3ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1887 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
TNNI3KUncharacterized protein. (724 aa)
ENSPCOP00000030811Sod_Cu domain-containing protein. (132 aa)
KCNH6Potassium voltage-gated channel subfamily H member 6. (991 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1958 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
OTOAOtoancorin. (1109 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1204 aa)
RGS21Regulator of G protein signaling 21. (85 aa)
CLCN1Chloride channel protein. (983 aa)
GPR88G protein-coupled receptor 88. (384 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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