46 items (Propithecus coquereli) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	PRKAG3	Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
	UPP1	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (314 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (734 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (553 aa)
	HSPA5	Uncharacterized protein; Belongs to the heat shock protein 70 family. (654 aa)
	SLC7A5	Solute carrier family 7 member 5. (489 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
	RRP8	Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (454 aa)
	PIK3R4	Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (574 aa)
	SESN1	Sestrin 1. (551 aa)
	ATG14	Autophagy related 14. (464 aa)
	CHKA	Choline kinase alpha. (449 aa)
	PICK1	Protein interacting with PRKCA 1. (417 aa)
	BRSK2	BR serine/threonine kinase 2. (721 aa)
	PLIN2	Perilipin; Belongs to the perilipin family. (434 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (540 aa)
	SIRT1	Sirtuin 1. (743 aa)
	TBL2	Transducin beta like 2. (446 aa)
	NUAK2	NUAK family kinase 2. (676 aa)
	NUAK1	NUAK family kinase 1. (667 aa)
	SESN2	Sestrin 2. (480 aa)
	KPTN	Kaptin, actin binding protein. (436 aa)
	BCL2	BCL2 apoptosis regulator. (234 aa)
	BRSK1	BR serine/threonine kinase 1. (736 aa)
	IMPACT	Impact RWD domain protein. (319 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (598 aa)
	LOC105811829	Uncharacterized protein; Belongs to the heat shock protein 70 family. (649 aa)
	SESN3	Sestrin 3. (495 aa)
	PLIN3	Perilipin; Belongs to the perilipin family. (431 aa)
	ITFG2	Integrin alpha FG-GAP repeat containing 2. (444 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
	NIM1K	NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. (436 aa)
	CPEB4	Cytoplasmic polyadenylation element binding protein 4. (729 aa)
	SLC2A1	Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (495 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (606 aa)
	PMAIP1	Uncharacterized protein. (54 aa)
	MTMR3	Myotubularin related protein 3. (1201 aa)
	XBP1	BZIP domain-containing protein. (377 aa)
	SZT2	SZT2 subunit of KICSTOR complex. (3429 aa)
	MYBBP1A	MYB binding protein 1a. (1342 aa)
	PRKAG1	Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
	SIK1	Uncharacterized protein. (777 aa)
	C12orf66	Chromosome 12 open reading frame 66. (468 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF4	EIF2AK3	ENSPCOP00000018079	ENSPCOP00000025600	Activating transcription factor 4.	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.932
ATF4	HSPA5	ENSPCOP00000018079	ENSPCOP00000026905	Activating transcription factor 4.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.719
ATF4	LOC105811829	ENSPCOP00000018079	ENSPCOP00000009246	Activating transcription factor 4.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.719
ATF4	NFE2L2	ENSPCOP00000018079	ENSPCOP00000002409	Activating transcription factor 4.	Nuclear factor, erythroid 2 like 2.	0.698
ATF4	PRKAA1	ENSPCOP00000018079	ENSPCOP00000023621	Activating transcription factor 4.	Non-specific serine/threonine protein kinase.	0.457
ATF4	PRKAA2	ENSPCOP00000018079	ENSPCOP00000027323	Activating transcription factor 4.	Non-specific serine/threonine protein kinase.	0.457
ATF4	SIK1	ENSPCOP00000018079	ENSPCOP00000006624	Activating transcription factor 4.	Uncharacterized protein.	0.447
ATF4	XBP1	ENSPCOP00000018079	ENSPCOP00000003952	Activating transcription factor 4.	BZIP domain-containing protein.	0.747
ATG14	BCL2	ENSPCOP00000031401	ENSPCOP00000020794	Autophagy related 14.	BCL2 apoptosis regulator.	0.573
ATG14	PIK3C3	ENSPCOP00000031401	ENSPCOP00000027325	Autophagy related 14.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.999
ATG14	PIK3R4	ENSPCOP00000031401	ENSPCOP00000023709	Autophagy related 14.	Phosphoinositide-3-kinase regulatory subunit 4.	0.999
ATG14	PRKAA1	ENSPCOP00000031401	ENSPCOP00000023621	Autophagy related 14.	Non-specific serine/threonine protein kinase.	0.680
ATG14	PRKAA2	ENSPCOP00000031401	ENSPCOP00000027323	Autophagy related 14.	Non-specific serine/threonine protein kinase.	0.677
ATG14	PRKAG2	ENSPCOP00000031401	ENSPCOP00000028387	Autophagy related 14.	Protein kinase AMP-activated non-catalytic subunit gamma 2.	0.654
BCL2	ATG14	ENSPCOP00000020794	ENSPCOP00000031401	BCL2 apoptosis regulator.	Autophagy related 14.	0.573
BCL2	HSPA5	ENSPCOP00000020794	ENSPCOP00000026905	BCL2 apoptosis regulator.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.411
BCL2	LOC105811829	ENSPCOP00000020794	ENSPCOP00000009246	BCL2 apoptosis regulator.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.411
BCL2	NFE2L2	ENSPCOP00000020794	ENSPCOP00000002409	BCL2 apoptosis regulator.	Nuclear factor, erythroid 2 like 2.	0.408
BCL2	PIK3C3	ENSPCOP00000020794	ENSPCOP00000027325	BCL2 apoptosis regulator.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.613
BCL2	PMAIP1	ENSPCOP00000020794	ENSPCOP00000002848	BCL2 apoptosis regulator.	Uncharacterized protein.	0.967