STRINGSTRING
LIF LIF OSM OSM TSLP TSLP GGNBP2 GGNBP2 LOC105822732 LOC105822732 ENSPCOP00000002561 ENSPCOP00000002561 PARP14 PARP14 EPO EPO PPP2R1A PPP2R1A SOCS1 SOCS1 ARL2BP ARL2BP CRLF1 CRLF1 INPP5F INPP5F IL6 IL6 LOC105823083 LOC105823083 IL23R IL23R IL2 IL2 LOC105811802 LOC105811802 ENSPCOP00000029403 ENSPCOP00000029403 SH2B3 SH2B3 IL6R IL6R CNOT7 CNOT7 FGFR3 FGFR3 TNFRSF1A TNFRSF1A SOCS3 SOCS3 CSF1R CSF1R CD40 CD40 ENSPCOP00000026048 ENSPCOP00000026048 IL31RA IL31RA IL21 IL21 PPP2CA PPP2CA CAV1 CAV1 LYN LYN ENSPCOP00000024480 ENSPCOP00000024480 FLT3 FLT3 KIT KIT PIBF1 PIBF1 PARP9 PARP9 IL20 IL20 OSBP OSBP CTF1 CTF1 IFNG IFNG HPX HPX IGF1 IGF1 IL15 IL15 TNFSF18 TNFSF18 IL4 IL4 ENSPCOP00000016892 ENSPCOP00000016892 CLCF1 CLCF1 IL12A IL12A CNTF CNTF ENSPCOP00000013862 ENSPCOP00000013862 HSF1 HSF1 ISL1 ISL1 IL12B IL12B LOC105822566 LOC105822566 IL6ST IL6ST PTPN2 PTPN2 NF2 NF2 CSF2 CSF2 IL22RA2 IL22RA2 ENSPCOP00000009718 ENSPCOP00000009718 IL23A IL23A IL24 IL24 HES5 HES5 FYN FYN TNFRSF18 TNFRSF18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LIFLIF interleukin 6 family cytokine. (202 aa)
OSMOncostatin M. (251 aa)
TSLPThymic stromal lymphopoietin. (158 aa)
GGNBP2Gametogenetin binding protein 2. (738 aa)
LOC105822732Uncharacterized protein. (245 aa)
ENSPCOP00000002561Uncharacterized protein. (546 aa)
PARP14Poly [ADP-ribose] polymerase. (1791 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (194 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
SOCS1Suppressor of cytokine signaling 1. (223 aa)
ARL2BPARL2_Bind_BART domain-containing protein. (163 aa)
CRLF1Cytokine receptor like factor 1. (437 aa)
INPP5FInositol polyphosphate-5-phosphatase F. (1132 aa)
IL6Uncharacterized protein. (211 aa)
LOC105823083Uncharacterized protein. (215 aa)
IL23RInterleukin 23 receptor. (602 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
LOC105811802Uncharacterized protein. (249 aa)
ENSPCOP00000029403Protein kinase domain-containing protein. (429 aa)
SH2B3SH2B adaptor protein 3. (539 aa)
IL6RInterleukin 6 receptor. (469 aa)
CNOT7Uncharacterized protein. (303 aa)
FGFR3Fibroblast growth factor receptor. (807 aa)
TNFRSF1ATNF receptor superfamily member 1A. (447 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
CD40CD40 molecule. (281 aa)
ENSPCOP00000026048ARL2_Bind_BART domain-containing protein. (109 aa)
IL31RAInterleukin 31 receptor A. (642 aa)
IL21Interleukin 21. (110 aa)
PPP2CASerine/threonine-protein phosphatase. (295 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
LYNTyrosine-protein kinase. (512 aa)
ENSPCOP00000024480Uncharacterized protein. (103 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (949 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (663 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (857 aa)
IL20Interleukin 20. (126 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (798 aa)
CTF1Cardiotrophin 1. (197 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
HPXHemopexin. (466 aa)
IGF1Insulin like growth factor 1. (208 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (135 aa)
TNFSF18TNF superfamily member 18. (199 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
ENSPCOP00000016892ARL2_Bind_BART domain-containing protein. (150 aa)
CLCF1Cardiotrophin like cytokine factor 1. (225 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
CNTFCiliary neurotrophic factor. (198 aa)
ENSPCOP00000013862SER_THR_PHOSPHATASE domain-containing protein. (209 aa)
HSF1Heat shock transcription factor 1. (531 aa)
ISL1ISL LIM homeobox 1. (349 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
LOC105822566Uncharacterized protein. (223 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
NF2Neurofibromin 2. (596 aa)
CSF2Colony stimulating factor 2. (146 aa)
IL22RA2Interleukin 22 receptor subunit alpha 2. (231 aa)
ENSPCOP00000009718ARL2_Bind_BART domain-containing protein. (80 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
IL24Interleukin 24. (220 aa)
HES5Orange domain-containing protein. (94 aa)
FYNTyrosine-protein kinase. (537 aa)
TNFRSF18Uncharacterized protein. (236 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
Server load: low (20%) [HD]