36 items (Propithecus coquereli) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	IL7R	Interleukin 7 receptor. (456 aa)
	LOC105827009	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (246 aa)
	SLC46A2	Solute carrier family 46 member 2. (475 aa)
	PMAIP1	Uncharacterized protein. (54 aa)
	JAK3	Tyrosine-protein kinase. (1123 aa)
	SPNS2	Sphingolipid transporter 2. (549 aa)
	LGALS2	Galectin. (114 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (787 aa)
	LOC105824591	AIG1-type G domain-containing protein. (312 aa)
	SIVA1	Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
	FOXN1	Forkhead box N1. (648 aa)
	TNFSF14	TNF superfamily member 14. (241 aa)
	ENSPCOP00000013858	Uncharacterized protein. (78 aa)
	PPP2R3C	Protein phosphatase 2 regulatory subunit B''gamma. (410 aa)
	ENSPCOP00000015361	Uncharacterized protein. (129 aa)
	ENSPCOP00000017736	Uncharacterized protein. (177 aa)
	NCKAP1L	NCK associated protein 1 like. (1138 aa)
	ZC3H8	Zinc finger CCCH-type containing 8. (306 aa)
	BAX	BCL2 associated X, apoptosis regulator. (199 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (975 aa)
	BCL2	BCL2 apoptosis regulator. (234 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (205 aa)
	CCNB2	Cyclin B2; Belongs to the cyclin family. (399 aa)
	ENSPCOP00000023046	Uncharacterized protein. (150 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (461 aa)
	DNAJA3	DnaJ heat shock protein family (Hsp40) member A3. (429 aa)
	BCL2L11	BCL2 like 11. (200 aa)
	SIT1	Signaling threshold regulating transmembrane adaptor 1. (196 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (531 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	IL20RB	Interleukin 20 receptor subunit beta. (312 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
	RIPK3	Receptor interacting serine/threonine kinase 3. (516 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1183 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	BAX	ENSPCOP00000028969	ENSPCOP00000019496	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 associated X, apoptosis regulator.	0.557
AKT1	BCL2	ENSPCOP00000028969	ENSPCOP00000020794	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 apoptosis regulator.	0.932
AKT1	BCL2L11	ENSPCOP00000028969	ENSPCOP00000024486	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 like 11.	0.523
AKT1	FOXN1	ENSPCOP00000028969	ENSPCOP00000011233	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box N1.	0.612
AKT1	IL7R	ENSPCOP00000028969	ENSPCOP00000000805	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Interleukin 7 receptor.	0.419
AKT1	JAK3	ENSPCOP00000028969	ENSPCOP00000004063	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.538
AKT1	NCKAP1L	ENSPCOP00000028969	ENSPCOP00000018855	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	NCK associated protein 1 like.	0.414
AKT1	PPP2R3C	ENSPCOP00000028969	ENSPCOP00000015207	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Protein phosphatase 2 regulatory subunit B''gamma.	0.853
AKT1	PPP3CB	ENSPCOP00000028969	ENSPCOP00000025321	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein phosphatase.	0.403
AKT1	TGFB1	ENSPCOP00000028969	ENSPCOP00000023065	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.653
BAX	AKT1	ENSPCOP00000019496	ENSPCOP00000028969	BCL2 associated X, apoptosis regulator.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.557
BAX	BCL2	ENSPCOP00000019496	ENSPCOP00000020794	BCL2 associated X, apoptosis regulator.	BCL2 apoptosis regulator.	0.985
BAX	BCL2L11	ENSPCOP00000019496	ENSPCOP00000024486	BCL2 associated X, apoptosis regulator.	BCL2 like 11.	0.999
BAX	PMAIP1	ENSPCOP00000019496	ENSPCOP00000002848	BCL2 associated X, apoptosis regulator.	Uncharacterized protein.	0.796
BAX	SIVA1	ENSPCOP00000019496	ENSPCOP00000011146	BCL2 associated X, apoptosis regulator.	Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.	0.611
BCL2	AKT1	ENSPCOP00000020794	ENSPCOP00000028969	BCL2 apoptosis regulator.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.932
BCL2	BAX	ENSPCOP00000020794	ENSPCOP00000019496	BCL2 apoptosis regulator.	BCL2 associated X, apoptosis regulator.	0.985
BCL2	BCL2L11	ENSPCOP00000020794	ENSPCOP00000024486	BCL2 apoptosis regulator.	BCL2 like 11.	0.995
BCL2	FADD	ENSPCOP00000020794	ENSPCOP00000021807	BCL2 apoptosis regulator.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.500
BCL2	JAK3	ENSPCOP00000020794	ENSPCOP00000004063	BCL2 apoptosis regulator.	Tyrosine-protein kinase.	0.455