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HLCS HLCS CASTOR1 CASTOR1 S100A8 S100A8 KARS1 KARS1 P3H2 P3H2 SLC1A3 SLC1A3 UBR1 UBR1 SCP2 SCP2 PADI6 PADI6 SHMT1 SHMT1 P4HTM P4HTM SERPINA5 SERPINA5 OGFOD2 OGFOD2 GRIN3A GRIN3A ID3 ID3 GRIN2D GRIN2D P4HA3 P4HA3 GPR143 GPR143 TDO2 TDO2 FABP1 FABP1 P3H1 P3H1 PLOD1 PLOD1 ENSPCOP00000005309 ENSPCOP00000005309 SLC1A1 SLC1A1 GRIN3B GRIN3B GLRA3 GLRA3 METTL26 METTL26 CYP26B1 CYP26B1 CRABP1 CRABP1 PLOD2 PLOD2 RXRA RXRA FABP3 FABP3 FABP5 FABP5 GLRB GLRB EGLN3 EGLN3 GLRA2 GLRA2 PCCA PCCA FOLR3 FOLR3 MTHFS MTHFS PLOD3 PLOD3 TM4SF5 TM4SF5 ENSPCOP00000009092 ENSPCOP00000009092 PIGS PIGS CASR CASR NOS3 NOS3 ASS1 ASS1 CRTAP CRTAP ALOX5AP ALOX5AP LOC105806815 LOC105806815 DDC DDC RYR2 RYR2 CYP26C1 CYP26C1 P4HA2 P4HA2 CYP27C1 CYP27C1 CEP104 CEP104 P4HA1 P4HA1 SESN3 SESN3 STX3 STX3 CYP26A1 CYP26A1 VDR VDR LCN12 LCN12 NR1H4 NR1H4 IGF2R IGF2R PC PC P2RX1 P2RX1 S100A9 S100A9 PAM PAM FTCDNL1 FTCDNL1 LRAT LRAT GAD2 GAD2 MCCC1 MCCC1 ALKBH3 ALKBH3 GCLC GCLC DDAH2 DDAH2 CRABP2 CRABP2 GNMT GNMT FTCD FTCD UROS UROS GLUD1 GLUD1 OTC OTC NOS1 NOS1 CPS1 CPS1 SRR SRR CYP2W1 CYP2W1 GRIN1 GRIN1 UBR2 UBR2 GCHFR GCHFR HBM HBM PHYH PHYH DBH DBH SESN2 SESN2 CAD CAD P3H4 P3H4 OGFOD1 OGFOD1 SESN1 SESN1 TYMS TYMS RARA RARA FOLR1 FOLR1 SHMT2 SHMT2 DBT DBT AARS2 AARS2 TH TH P3H3 P3H3 GLRA1 GLRA1 GRIN2B GRIN2B EGLN1 EGLN1 EGLN2 EGLN2 GLDC GLDC YARS2 YARS2 FOLR2 FOLR2 GLRA4 GLRA4 OXER1 OXER1 SLC19A1 SLC19A1 ACACB ACACB DDAH1 DDAH1 PPARD PPARD TAT TAT SLC46A1 SLC46A1 SCLY SCLY OGFOD3 OGFOD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HLCSHolocarboxylase synthetase. (727 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (347 aa)
S100A8S100 calcium binding protein A8; Belongs to the S-100 family. (89 aa)
KARS1Lysine--tRNA ligase. (568 aa)
P3H2Prolyl 3-hydroxylase 2. (481 aa)
SLC1A3Amino acid transporter. (542 aa)
UBR1E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1620 aa)
SCP2Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (495 aa)
PADI6Peptidyl arginine deiminase 6. (660 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (441 aa)
P4HTMProlyl 4-hydroxylase, transmembrane. (501 aa)
SERPINA5Serpin family A member 5; Belongs to the serpin family. (326 aa)
OGFOD22-oxoglutarate and iron dependent oxygenase domain containing 2. (350 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1115 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1337 aa)
P4HA3Prolyl 4-hydroxylase subunit alpha 3. (583 aa)
GPR143G protein-coupled receptor 143. (323 aa)
TDO2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa)
FABP1FABP domain-containing protein. (69 aa)
P3H1Prolyl 3-hydroxylase 1. (771 aa)
PLOD1Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1. (727 aa)
ENSPCOP00000005309Fe2OG dioxygenase domain-containing protein. (121 aa)
SLC1A1Amino acid transporter. (524 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1043 aa)
GLRA3Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (398 aa)
METTL26Methyltransferase like 26. (204 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
CRABP1Cellular retinoic acid binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa)
PLOD2Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (505 aa)
RXRARetinoid X receptor alpha. (469 aa)
FABP3Fatty acid binding protein 3; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
FABP5Fatty acid binding protein 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
GLRBGlycine receptor beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (466 aa)
EGLN3Fe2OG dioxygenase domain-containing protein. (239 aa)
GLRA2Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (451 aa)
PCCAPropionyl-CoA carboxylase subunit alpha. (702 aa)
FOLR3Folate receptor gamma. (249 aa)
MTHFSUncharacterized protein. (139 aa)
PLOD3Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (739 aa)
TM4SF5Transmembrane 4 L six family member 5. (195 aa)
ENSPCOP00000009092E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (366 aa)
PIGSPhosphatidylinositol glycan anchor biosynthesis class S. (555 aa)
CASRCalcium sensing receptor. (1076 aa)
NOS3Nitric oxide synthase 3. (994 aa)
ASS1Argininosuccinate synthase 1. (412 aa)
CRTAPCartilage associated protein. (401 aa)
ALOX5APArachidonate 5-lipoxygenase activating protein. (217 aa)
LOC105806815Uncharacterized protein; Belongs to the cytochrome P450 family. (284 aa)
DDCDopa decarboxylase. (480 aa)
RYR2Ryanodine receptor 2. (4825 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
P4HA2Prolyl 4-hydroxylase subunit alpha 2. (535 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (372 aa)
CEP104Centrosomal protein 104. (925 aa)
P4HA1Prolyl 4-hydroxylase subunit alpha 1. (456 aa)
SESN3Sestrin 3. (495 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (290 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
VDRVitamin D receptor. (474 aa)
LCN12Lipocalin 12; Belongs to the calycin superfamily. Lipocalin family. (192 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
IGF2RInsulin like growth factor 2 receptor. (2496 aa)
PCPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1178 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
S100A9S100 calcium binding protein A9; Belongs to the S-100 family. (154 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (695 aa)
FTCDNL1Formiminotransferase cyclodeaminase N-terminal like. (146 aa)
LRATLecithin retinol acyltransferase. (230 aa)
GAD2Glutamate decarboxylase 2. (584 aa)
MCCC1Methylcrotonoyl-CoA carboxylase 1. (725 aa)
ALKBH3AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase. (285 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
DDAH2Dimethylarginine dimethylaminohydrolase 2. (285 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
GNMTGlycine N-methyltransferase. (295 aa)
FTCDFormimidoyltransferase cyclodeaminase. (579 aa)
UROSUroporphyrinogen III synthase. (265 aa)
GLUD1ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (558 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1434 aa)
CPS1Carbamoyl-phosphate synthase 1. (1310 aa)
SRRPALP domain-containing protein. (151 aa)
CYP2W1Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (490 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1482 aa)
GCHFRGTP cyclohydrolase I feedback regulator. (84 aa)
HBMHemoglobin subunit mu; Belongs to the globin family. (141 aa)
PHYHPhytanoyl-CoA 2-hydroxylase. (239 aa)
DBHDopamine beta-hydroxylase. (620 aa)
SESN2Sestrin 2. (480 aa)
CADCarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2227 aa)
P3H4Prolyl 3-hydroxylase family member 4 (non-enzymatic). (443 aa)
OGFOD12-oxoglutarate and iron dependent oxygenase domain containing 1. (541 aa)
SESN1Sestrin 1. (551 aa)
TYMSThymidylate synthetase. (313 aa)
RARARetinoic acid receptor alpha. (472 aa)
FOLR1Folate receptor alpha. (257 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
DBTDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (458 aa)
AARS2Alanyl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (985 aa)
THTyrosine hydroxylase. (497 aa)
P3H3Prolyl 3-hydroxylase 3. (742 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1485 aa)
EGLN1Uncharacterized protein. (427 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (405 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1020 aa)
YARS2Tyrosine--tRNA ligase. (478 aa)
FOLR2Folate receptor beta. (251 aa)
GLRA4Glycine receptor alpha 4; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
OXER1G_PROTEIN_RECEP_F1_2 domain-containing protein. (330 aa)
SLC19A1Solute carrier family 19 member 1. (476 aa)
ACACBAcetyl-CoA carboxylase beta. (2172 aa)
DDAH1Dimethylarginine dimethylaminohydrolase 1. (285 aa)
PPARDPeroxisome proliferator activated receptor delta. (440 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
SLC46A1Solute carrier family 46 member 1. (459 aa)
SCLYSelenocysteine lyase. (396 aa)
OGFOD32-oxoglutarate and iron dependent oxygenase domain containing 3. (315 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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