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| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa) |
| | TFAP2A | Transcription factor AP-2 alpha. (439 aa) |
| | DNAJC5B | DnaJ heat shock protein family (Hsp40) member C5 beta. (199 aa) |
| | VPS54 | VPS54 subunit of GARP complex. (976 aa) |
| | GDF5 | Growth differentiation factor 5. (499 aa) |
| | GBE1 | 1,4-alpha-glucan branching enzyme 1. (702 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (199 aa) |
| | BIRC5 | Baculoviral IAP repeat containing 5. (142 aa) |
| | FBXW7 | F-box and WD repeat domain containing 7. (707 aa) |
| | NAE1 | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (475 aa) |
| | RETREG1 | Reticulophagy regulator 1. (356 aa) |
| | CX3CL1 | C-X3-C motif chemokine ligand 1. (405 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | BCL2 | BCL2 apoptosis regulator. (234 aa) |
| | OXR1 | Oxidation resistance 1. (875 aa) |
| | AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1193 aa) |
| | IL27RA | Interleukin 27 receptor subunit alpha. (637 aa) |
| | PPARGC1A | PPARG coactivator 1 alpha. (809 aa) |
| | ANGPT1 | Angiopoietin 1. (408 aa) |
| | STAMBP | STAM binding protein. (423 aa) |
| | BTG2 | BTG anti-proliferation factor 2. (158 aa) |
| | NTF3 | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa) |
| | GDNF | Glial cell derived neurotrophic factor. (228 aa) |
| | BACE1 | Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa) |
| | GABRB2 | Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (430 aa) |
| | TFAP2D | Transcription factor AP-2 delta. (452 aa) |
| | NR4A2 | Nuclear receptor subfamily 4 group A member 2. (598 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | CDC34 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (235 aa) |
| | LOC105825161 | RECA_2 domain-containing protein. (281 aa) |
| | AXL | AXL receptor tyrosine kinase. (894 aa) |
| | CORO1A | Coronin; Belongs to the WD repeat coronin family. (461 aa) |
| | GRIK5 | Glutamate ionotropic receptor kainate type subunit 5. (980 aa) |
| | SIX4 | SIX homeobox 4. (782 aa) |
| | SARM1 | Sterile alpha and TIR motif containing 1. (724 aa) |
| | ENSPCOP00000024116 | Uncharacterized protein. (120 aa) |
| | VEGFA | Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa) |
| | ENSPCOP00000024480 | Uncharacterized protein. (103 aa) |
| | BCL2L11 | BCL2 like 11. (200 aa) |
| | FBXW9 | F-box and WD repeat domain containing 9. (478 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (745 aa) |
| | PINK1 | PTEN induced kinase 1. (581 aa) |
| | POU4F1 | POU domain protein. (421 aa) |
| | KCNB1 | Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa) |
| | MECP2 | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (500 aa) |
| | ENSPCOP00000025432 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (747 aa) |
| | CLN8 | CLN8 transmembrane ER and ERGIC protein. (288 aa) |
| | SRPK2 | SRSF protein kinase 2. (698 aa) |
| | MCL1 | MCL1 apoptosis regulator, BCL2 family member. (350 aa) |
| | GRID2 | Glutamate ionotropic receptor delta type subunit 2. (962 aa) |
| | VSTM2L | V-set and transmembrane domain containing 2 like. (204 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | NF1 | Neurofibromin 1. (2841 aa) |
| | CDK5 | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa) |
| | PTPRZ1 | Protein tyrosine phosphatase receptor type Z1. (2086 aa) |
| | EGLN2 | Egl-9 family hypoxia inducible factor 2. (405 aa) |
| | NEFL | Neurofilament light; Belongs to the intermediate filament family. (545 aa) |
| | ERBB3 | Erb-b2 receptor tyrosine kinase 3. (1337 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (967 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (347 aa) |
| | MAP3K12 | Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (891 aa) |
| | PLXND1 | Plexin D1. (1928 aa) |
| | MAP3K11 | Mitogen-activated protein kinase kinase kinase. (847 aa) |
| | ALKBH1 | AlkB homolog 1, histone H2A dioxygenase. (389 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (406 aa) |
| | PARK7 | DJ-1_PfpI domain-containing protein. (155 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | PLA2G3 | Phospholipase A2 group III. (506 aa) |
| | UBE2M | Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa) |
| | ENSPCOP00000030811 | Sod_Cu domain-containing protein. (132 aa) |
| | ZPR1 | Uncharacterized protein. (459 aa) |
| | AMBRA1 | Autophagy and beclin 1 regulator 1. (1270 aa) |
| | FGF20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | EN1 | Homeobox protein engrailed-like. (395 aa) |
| | G6PD | Glucose-6-phosphate dehydrogenase. (558 aa) |
| | MAP2K4 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa) |
| | MYBL2 | MYB proto-oncogene like 2. (699 aa) |
| | ENSPCOP00000031725 | Protein kinase domain-containing protein. (272 aa) |
| | SIGMAR1 | Sigma non-opioid intracellular receptor 1. (223 aa) |
| | GABRA5 | Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa) |
| | ENSPCOP00000002776 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (330 aa) |
| | LANCL1 | LanC like 1. (399 aa) |
| | NONO | Non-POU domain containing octamer binding. (470 aa) |
| | ADORA2A | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (411 aa) |
| | TOX3 | TOX high mobility group box family member 3. (575 aa) |
| | FOXB1 | Forkhead box B1. (325 aa) |
| | NSMF | NMDA receptor synaptonuclear signaling and neuronal migration factor. (532 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) |
| | LOC105812780 | Uncharacterized protein. (433 aa) |
| | BDNF | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa) |
| | CPEB4 | Cytoplasmic polyadenylation element binding protein 4. (729 aa) |
| | NES | Nestin; Belongs to the intermediate filament family. (1631 aa) |
| | GRN | Granulin precursor. (591 aa) |
| | EN2 | Homeobox protein engrailed-like. (333 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | NTRK2 | Tyrosine-protein kinase receptor. (838 aa) |
| | TRIM2 | Tripartite motif containing 2. (777 aa) |
| | RASA1 | RAS p21 protein activator 1. (623 aa) |
| | CDK5R1 | Cyclin-dependent kinase 5 activator. (306 aa) |
| | DLX1 | Distal-less homeobox 1. (255 aa) |
| | KIF14 | Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1498 aa) |
| | GCLM | Glutamate-cysteine ligase modifier subunit. (274 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | SYNGAP1 | Synaptic Ras GTPase activating protein 1. (1416 aa) |
| | ENSPCOP00000003181 | PBPe domain-containing protein. (242 aa) |
| | SNCB | Beta-synuclein; Belongs to the synuclein family. (134 aa) |
| | BARHL1 | BarH like homeobox 1. (327 aa) |
| | PPT1 | Palmitoyl-protein thioesterase 1. (302 aa) |
| | AKT1S1 | AKT1 substrate 1. (274 aa) |
| | AIFM1 | Apoptosis inducing factor mitochondria associated 1. (613 aa) |
| | MT3 | Metallothionein 3; Belongs to the metallothionein superfamily. Type 1 family. (114 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1187 aa) |
| | DNAJC5 | DnaJ heat shock protein family (Hsp40) member C5. (198 aa) |
| | THAP11 | THAP domain containing 11. (304 aa) |
| | ENSPCOP00000004143 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (136 aa) |
| | LOC105825287 | DJ-1_PfpI domain-containing protein. (189 aa) |
| | BOK | BCL2 family apoptosis regulator BOK. (213 aa) |
| | HYOU1 | Hypoxia up-regulated 1. (997 aa) |
| | HIF1A | Hypoxia inducible factor 1 subunit alpha. (826 aa) |
| | ITGA1 | Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1025 aa) |
| | KDM2B | Lysine demethylase 2B. (1337 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (297 aa) |
| | FAIM2 | Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (316 aa) |
| | ENSPCOP00000005309 | Fe2OG dioxygenase domain-containing protein. (121 aa) |
| | CITED1 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (221 aa) |
| | CRLF1 | Cytokine receptor like factor 1. (437 aa) |
| | SLC1A1 | Amino acid transporter. (524 aa) |
| | NRBP2 | Nuclear receptor binding protein 2. (499 aa) |
| | PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (868 aa) |
| | UNC5B | Unc-5 netrin receptor B. (932 aa) |
| | ADNP | Activity dependent neuroprotector homeobox. (1102 aa) |
| | LGMN | Legumain. (433 aa) |
| | WFS1 | Wolframin ER transmembrane glycoprotein. (887 aa) |
| | SOD2 | Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | ROCK1 | Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1316 aa) |
| | EGLN3 | Fe2OG dioxygenase domain-containing protein. (239 aa) |
| | VEGFB | Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa) |
| | GATA3 | Uncharacterized protein. (444 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (953 aa) |
| | MEF2C | Myocyte enhancer factor 2C. (483 aa) |
| | LOC105822409 | Eph LBD domain-containing protein. (279 aa) |
| | ENSPCOP00000009641 | Uncharacterized protein. (136 aa) |
| | SIX1 | SIX homeobox 1. (284 aa) |
| | SEMA3E | Sema domain-containing protein; Belongs to the semaphorin family. (390 aa) |
| | AARS1 | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (969 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (796 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa) |
| | ENSPCOP00000011171 | Uncharacterized protein. (575 aa) |
| | CNTFR | Ciliary neurotrophic factor receptor. (372 aa) |
| | IL6ST | Interleukin 6 signal transducer. (918 aa) |
| | DRAXIN | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa) |
| | MDK | Midkine. (143 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (224 aa) |
| | FGF8 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa) |
| | ISL1 | ISL LIM homeobox 1. (349 aa) |
| | GSK3A | Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa) |
| | PITX3 | Homeobox protein. (302 aa) |
| | SLC30A10 | Solute carrier family 30 member 10. (486 aa) |
| | CNTF | Ciliary neurotrophic factor. (198 aa) |
| | RAPSN | Receptor associated protein of the synapse. (412 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa) |
| | PIK3CA | Phosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa) |
| | SOD1 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (153 aa) |
| | ENSPCOP00000015642 | DJ-1_PfpI domain-containing protein. (175 aa) |
| | GFRAL | GDNF family receptor alpha like. (338 aa) |
| | TFAP2B | Transcription factor AP-2 beta. (460 aa) |
| | PCSK9 | Proprotein convertase subtilisin/kexin type 9. (693 aa) |
| | MAG | Myelin associated glycoprotein. (626 aa) |
| | CHL1 | Cell adhesion molecule L1 like. (1010 aa) |
| | BBC3 | BCL2 binding component 3. (260 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (460 aa) |
| | CASP2 | Caspase 2; Belongs to the peptidase C14A family. (452 aa) |
| | CLCF1 | Cardiotrophin like cytokine factor 1. (225 aa) |
| | ENSPCOP00000016685 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (203 aa) |
| | NRP1 | Neuropilin; Belongs to the neuropilin family. (923 aa) |
| | GCLC | Glutamate-cysteine ligase catalytic subunit. (637 aa) |
| | CX3CR1 | C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (379 aa) |
| | ATM | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2635 aa) |
| | ATF4 | Activating transcription factor 4. (351 aa) |
| | ADAM8 | ADAM metallopeptidase domain 8. (812 aa) |
