STRINGSTRING
SEMA3E SEMA3E MEF2C MEF2C NFATC4 NFATC4 VEGFB VEGFB ROCK1 ROCK1 TGFB3 TGFB3 SOD2 SOD2 WFS1 WFS1 LGMN LGMN ADNP ADNP UNC5B UNC5B MSH2 MSH2 PRKCI PRKCI NRBP2 NRBP2 SLC1A1 SLC1A1 CRLF1 CRLF1 CITED1 CITED1 FAIM2 FAIM2 XRCC4 XRCC4 KDR KDR KDM2B KDM2B HIF1A HIF1A HYOU1 HYOU1 BOK BOK LOC105825287 LOC105825287 ENSPCOP00000004143 ENSPCOP00000004143 THAP11 THAP11 DNAJC5 DNAJC5 HIPK2 HIPK2 MT3 MT3 PPT1 PPT1 BARHL1 BARHL1 SNCB SNCB ENSPCOP00000003181 ENSPCOP00000003181 SYNGAP1 SYNGAP1 ENSPCOP00000002776 ENSPCOP00000002776 NONO NONO ADORA2A ADORA2A TOX3 TOX3 FOXB1 FOXB1 PRKCG PRKCG LOC105812780 LOC105812780 BDNF BDNF CPEB4 CPEB4 NES NES GRN GRN EN2 EN2 NTRK2 NTRK2 RASA1 RASA1 DLX1 DLX1 KIF14 KIF14 GCLM GCLM NTRK1 NTRK1 AARS1 AARS1 SIX1 SIX1 GABRA5 GABRA5 ENSPCOP00000031725 ENSPCOP00000031725 MAP2K4 MAP2K4 EN1 EN1 FGF20 FGF20 AMBRA1 AMBRA1 ZPR1 ZPR1 ENSPCOP00000030811 ENSPCOP00000030811 PLA2G3 PLA2G3 CCND1 CCND1 PARK7 PARK7 ALKBH1 ALKBH1 PLXND1 PLXND1 MAP3K12 MAP3K12 CEBPB CEBPB PTK2B PTK2B ERBB3 ERBB3 NEFL NEFL PTPRZ1 PTPRZ1 VSTM2L VSTM2L CLN8 CLN8 ENSPCOP00000025432 ENSPCOP00000025432 MECP2 MECP2 POU4F1 POU4F1 PINK1 PINK1 BRAF BRAF VEGFA VEGFA ENSPCOP00000024116 ENSPCOP00000024116 SIX4 SIX4 CORO1A CORO1A AXL AXL LOC105825161 LOC105825161 NR4A2 NR4A2 TFAP2D TFAP2D GABRB2 GABRB2 GDNF GDNF NTF3 NTF3 BTG2 BTG2 STAMBP STAMBP ANGPT1 ANGPT1 PPARGC1A PPARGC1A IL27RA IL27RA AGAP2 AGAP2 OXR1 OXR1 BCL2 BCL2 BCL2L1 BCL2L1 CX3CL1 CX3CL1 RETREG1 RETREG1 BIRC5 BIRC5 BAX BAX GBE1 GBE1 GDF5 GDF5 VPS54 VPS54 DNAJC5B DNAJC5B ADAM8 ADAM8 CX3CR1 CX3CR1 GCLC GCLC NRP1 NRP1 CLCF1 CLCF1 PRKN PRKN CHL1 CHL1 MAG MAG TFAP2B TFAP2B GFRAL GFRAL ENSPCOP00000015642 ENSPCOP00000015642 SOD1 SOD1 PIK3CA PIK3CA CNTF CNTF SLC30A10 SLC30A10 ISL1 ISL1 FGF8 FGF8 MDK MDK DRAXIN DRAXIN IL6ST IL6ST CNTFR CNTFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEMA3ESema domain-containing protein; Belongs to the semaphorin family. (390 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
NFATC4Nuclear factor of activated T cells 4. (953 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1316 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
WFS1Wolframin ER transmembrane glycoprotein. (887 aa)
LGMNLegumain. (433 aa)
ADNPActivity dependent neuroprotector homeobox. (1102 aa)
UNC5BUnc-5 netrin receptor B. (932 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (868 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa)
NRBP2Nuclear receptor binding protein 2. (499 aa)
SLC1A1Amino acid transporter. (524 aa)
CRLF1Cytokine receptor like factor 1. (437 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (221 aa)
FAIM2Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (316 aa)
XRCC4X-ray repair cross complementing 4. (297 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
KDM2BLysine demethylase 2B. (1337 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
HYOU1Hypoxia up-regulated 1. (997 aa)
BOKBCL2 family apoptosis regulator BOK. (213 aa)
LOC105825287DJ-1_PfpI domain-containing protein. (189 aa)
ENSPCOP00000004143Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (136 aa)
THAP11THAP domain containing 11. (304 aa)
DNAJC5DnaJ heat shock protein family (Hsp40) member C5. (198 aa)
HIPK2Homeodomain interacting protein kinase 2. (1187 aa)
MT3Metallothionein 3; Belongs to the metallothionein superfamily. Type 1 family. (114 aa)
PPT1Palmitoyl-protein thioesterase 1. (302 aa)
BARHL1BarH like homeobox 1. (327 aa)
SNCBBeta-synuclein; Belongs to the synuclein family. (134 aa)
ENSPCOP00000003181PBPe domain-containing protein. (242 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1416 aa)
ENSPCOP00000002776Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (330 aa)
NONONon-POU domain containing octamer binding. (470 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (411 aa)
TOX3TOX high mobility group box family member 3. (575 aa)
FOXB1Forkhead box B1. (325 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
LOC105812780Uncharacterized protein. (433 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (729 aa)
NESNestin; Belongs to the intermediate filament family. (1631 aa)
GRNGranulin precursor. (591 aa)
EN2Homeobox protein engrailed-like. (333 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
RASA1RAS p21 protein activator 1. (623 aa)
DLX1Distal-less homeobox 1. (255 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1498 aa)
GCLMGlutamate-cysteine ligase modifier subunit. (274 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
AARS1Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (969 aa)
SIX1SIX homeobox 1. (284 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
ENSPCOP00000031725Protein kinase domain-containing protein. (272 aa)
MAP2K4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
EN1Homeobox protein engrailed-like. (395 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1270 aa)
ZPR1Uncharacterized protein. (459 aa)
ENSPCOP00000030811Sod_Cu domain-containing protein. (132 aa)
PLA2G3Phospholipase A2 group III. (506 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PARK7DJ-1_PfpI domain-containing protein. (155 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (389 aa)
PLXND1Plexin D1. (1928 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (891 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (967 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1337 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (545 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2086 aa)
VSTM2LV-set and transmembrane domain containing 2 like. (204 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (288 aa)
ENSPCOP00000025432Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (747 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (500 aa)
POU4F1POU domain protein. (421 aa)
PINK1PTEN induced kinase 1. (581 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
ENSPCOP00000024116Uncharacterized protein. (120 aa)
SIX4SIX homeobox 4. (782 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
LOC105825161RECA_2 domain-containing protein. (281 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
TFAP2DTranscription factor AP-2 delta. (452 aa)
GABRB2Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (430 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
STAMBPSTAM binding protein. (423 aa)
ANGPT1Angiopoietin 1. (408 aa)
PPARGC1APPARG coactivator 1 alpha. (809 aa)
IL27RAInterleukin 27 receptor subunit alpha. (637 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1193 aa)
OXR1Oxidation resistance 1. (875 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
BCL2L1BCL2 like 1. (233 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (405 aa)
RETREG1Reticulophagy regulator 1. (356 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
BAXBCL2 associated X, apoptosis regulator. (199 aa)
GBE11,4-alpha-glucan branching enzyme 1. (702 aa)
GDF5Growth differentiation factor 5. (499 aa)
VPS54VPS54 subunit of GARP complex. (976 aa)
DNAJC5BDnaJ heat shock protein family (Hsp40) member C5 beta. (199 aa)
ADAM8ADAM metallopeptidase domain 8. (812 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (379 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
CLCF1Cardiotrophin like cytokine factor 1. (225 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (460 aa)
CHL1Cell adhesion molecule L1 like. (1010 aa)
MAGMyelin associated glycoprotein. (626 aa)
TFAP2BTranscription factor AP-2 beta. (460 aa)
GFRALGDNF family receptor alpha like. (338 aa)
ENSPCOP00000015642DJ-1_PfpI domain-containing protein. (175 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
CNTFCiliary neurotrophic factor. (198 aa)
SLC30A10Solute carrier family 30 member 10. (486 aa)
ISL1ISL LIM homeobox 1. (349 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
MDKMidkine. (143 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
CNTFRCiliary neurotrophic factor receptor. (372 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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