STRINGSTRING
CASP6 CASP6 AIM2 AIM2 ENSPCOP00000006977 ENSPCOP00000006977 GFER GFER POLR3B POLR3B PSPC1 PSPC1 ENSPCOP00000006340 ENSPCOP00000006340 PRKDC PRKDC LEP LEP XRCC5 XRCC5 IRF3 IRF3 PQBP1 PQBP1 HAVCR2 HAVCR2 FCN1 FCN1 MED1 MED1 TOMM70 TOMM70 STING1 STING1 LOC105816671 LOC105816671 MNDA MNDA ZCCHC3 ZCCHC3 SOCS1 SOCS1 YTHDF2 YTHDF2 BIRC3 BIRC3 ENSPCOP00000002983 ENSPCOP00000002983 ENSPCOP00000002888 ENSPCOP00000002888 TNFAIP3 TNFAIP3 POLR3D POLR3D ATG12 ATG12 LOC105811802 LOC105811802 PTPN11 PTPN11 ZBP1 ZBP1 XRCC6 XRCC6 NOD2 NOD2 TXK TXK TRIM41 TRIM41 SFPQ SFPQ CNOT7 CNOT7 NR1H2 NR1H2 FCN2 FCN2 IKBKE IKBKE IFI35 IFI35 CRTAM CRTAM N4BP1 N4BP1 LAG3 LAG3 MATR3 MATR3 SERPINB9 SERPINB9 LOC105809396-2 LOC105809396-2 USP27X USP27X ARG1 ARG1 DUSP10 DUSP10 GBP5 GBP5 IL21 IL21 POLR3C POLR3C LRP8 LRP8 LYN LYN METTL3 METTL3 FCN3 FCN3 DNAJA3 DNAJA3 NLRC3 NLRC3 CASP8 CASP8 NR1H3 NR1H3 EREG EREG TIRAP TIRAP PARP9 PARP9 AKIRIN2 AKIRIN2 POLR3G POLR3G CLNK CLNK COCH COCH COLEC10 COLEC10 FADD FADD RIOK3 RIOK3 BIRC2 BIRC2 RNF135 RNF135 CREBBP CREBBP IKBKB IKBKB LAMP1 LAMP1 PAK2 PAK2 HPX HPX MASP1 MASP1 IRAK3 IRAK3 MAVS MAVS EP300 EP300 DHX58 DHX58 SERPING1 SERPING1 CD160 CD160 SRC SRC FGR FGR ADAM8 ADAM8 CRK CRK MASP2 MASP2 ACOD1 ACOD1 PYCARD PYCARD NMI NMI CADM1 CADM1 PLA2G5 PLA2G5 LBP LBP CARD9 CARD9 NCR3 NCR3 CGAS CGAS NECTIN2 NECTIN2 TBK1 TBK1 TYROBP TYROBP COLEC11 COLEC11 IL12A IL12A SIN3A SIN3A LOC105826387 LOC105826387 SLAMF6 SLAMF6 TRAFD1 TRAFD1 TLR8 TLR8 OTOP1 OTOP1 VAV1 VAV1 CEACAM1 CEACAM1 UBE2K UBE2K TRIM62 TRIM62 PTPN6 PTPN6 CD96 CD96 CLEC12B CLEC12B SLC15A4 SLC15A4 NLRC5 NLRC5 C3 C3 IL12B IL12B ERAP1 ERAP1 TREM2 TREM2 MUL1 MUL1 SH2D1A SH2D1A BANF1 BANF1 ISG15 ISG15 PTPN2 PTPN2 PLCG2 PLCG2 USP15 USP15 ADAR ADAR ENSPCOP00000011549 ENSPCOP00000011549 TTLL12 TTLL12 NLRX1 NLRX1 VSIG4 VSIG4 IRF7 IRF7 FAM3A FAM3A LOC105824591 LOC105824591 STAT2 STAT2 APPL2 APPL2 APOE APOE LYAR LYAR CLEC6A CLEC6A RBM14 RBM14 ENSPCOP00000009822 ENSPCOP00000009822 LOC105817821 LOC105817821 ENSPCOP00000009677 ENSPCOP00000009677 SAMHD1 SAMHD1 SYK SYK APPL1 APPL1 IRF1 IRF1 CACTIN CACTIN PTPN1 PTPN1 CDC37 CDC37 PTPN22 PTPN22 RASGRP1 RASGRP1 ATG5 ATG5 FYN FYN ENSPCOP00000008287 ENSPCOP00000008287 CD226 CD226 MMP12 MMP12 WNT5A WNT5A NCF1 NCF1 PAK1 PAK1 LOC105816653 LOC105816653 SH2D1B SH2D1B ZNFX1 ZNFX1 TKFC TKFC POLR3F POLR3F GRN GRN YTHDF3 YTHDF3 TRIM5 TRIM5 LOC105826384 LOC105826384 SLAMF8 SLAMF8 NFE2L2 NFE2L2 DCST1 DCST1 MBL2 MBL2 LOC105822732 LOC105822732 DRD2 DRD2 PARP14 PARP14 NONO NONO
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASP6Caspase 6; Belongs to the peptidase C14A family. (293 aa)
AIM2Absent in melanoma 2. (260 aa)
ENSPCOP00000006977IRF-3 domain-containing protein. (275 aa)
GFERSulfhydryl oxidase. (206 aa)
POLR3BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1085 aa)
PSPC1Paraspeckle component 1. (503 aa)
ENSPCOP00000006340Uncharacterized protein. (134 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (677 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (419 aa)
PQBP1Polyglutamine binding protein 1. (265 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (272 aa)
FCN1Ficolin 1. (253 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (553 aa)
STING1Transmembrane protein 173. (374 aa)
LOC105816671C-type lectin domain-containing protein. (82 aa)
MNDAMyeloid cell nuclear differentiation antigen. (395 aa)
ZCCHC3Zinc finger CCHC-type containing 3. (401 aa)
SOCS1Suppressor of cytokine signaling 1. (223 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (592 aa)
BIRC3Baculoviral IAP repeat containing 3. (597 aa)
ENSPCOP00000002983Uncharacterized protein. (130 aa)
ENSPCOP00000002888Uncharacterized protein. (54 aa)
TNFAIP3TNF alpha induced protein 3. (792 aa)
POLR3DRNA polymerase III subunit D. (398 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
LOC105811802Uncharacterized protein. (249 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
ZBP1Z-DNA binding protein 1. (415 aa)
XRCC6X-ray repair cross complementing 6. (496 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
TXKTyrosine-protein kinase. (581 aa)
TRIM41Tripartite motif containing 41. (629 aa)
SFPQSplicing factor proline and glutamine rich. (706 aa)
CNOT7Uncharacterized protein. (303 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (459 aa)
FCN2Ficolin 2. (278 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
IFI35Interferon induced protein 35. (285 aa)
CRTAMCytotoxic and regulatory T cell molecule. (272 aa)
N4BP1NEDD4 binding protein 1. (896 aa)
LAG3Lymphocyte activating 3. (508 aa)
MATR3Uncharacterized protein. (847 aa)
SERPINB9Serpin family B member 9; Belongs to the serpin family. (374 aa)
LOC105809396-2Ig domain-containing protein. (193 aa)
USP27XUbiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (438 aa)
ARG1Arginase. (229 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
GBP5Guanylate binding protein 5. (583 aa)
IL21Interleukin 21. (110 aa)
POLR3CRNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (463 aa)
LRP8LDL receptor related protein 8. (956 aa)
LYNTyrosine-protein kinase. (512 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
FCN3Ficolin 3. (299 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (429 aa)
NLRC3NLR family CARD domain containing 3. (1103 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (454 aa)
EREGEpiregulin. (166 aa)
TIRAPTIR domain containing adaptor protein. (198 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (857 aa)
AKIRIN2Akirin 2. (203 aa)
POLR3GUncharacterized protein. (82 aa)
CLNKCytokine dependent hematopoietic cell linker. (420 aa)
COCHCochlin. (550 aa)
COLEC10Collectin subfamily member 10. (208 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (205 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
BIRC2Baculoviral IAP repeat containing 2. (619 aa)
RNF135Ring finger protein 135. (421 aa)
CREBBPCREB binding protein. (2449 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (747 aa)
LAMP1Lysosomal associated membrane protein 1. (384 aa)
PAK2Non-specific serine/threonine protein kinase. (492 aa)
HPXHemopexin. (466 aa)
MASP1Mannan binding lectin serine peptidase 1. (699 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (505 aa)
MAVSMitochondrial antiviral signaling protein. (514 aa)
EP300E1A binding protein p300. (2424 aa)
DHX58DExH-box helicase 58. (678 aa)
SERPING1Serpin family G member 1; Belongs to the serpin family. (491 aa)
CD160CD160 molecule. (220 aa)
SRCTyrosine-protein kinase. (543 aa)
FGRTyrosine-protein kinase. (495 aa)
ADAM8ADAM metallopeptidase domain 8. (812 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
MASP2Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (686 aa)
ACOD1Aconitate decarboxylase 1. (478 aa)
PYCARDPYD and CARD domain containing. (195 aa)
NMIN-myc and STAT interactor. (313 aa)
CADM1Cell adhesion molecule 1. (472 aa)
PLA2G5Phospholipase A(2). (138 aa)
LBPLipopolysaccharide binding protein. (481 aa)
CARD9Caspase recruitment domain family member 9. (536 aa)
NCR3Natural cytotoxicity triggering receptor 3. (180 aa)
CGASCyclic GMP-AMP synthase. (523 aa)
NECTIN2Nectin cell adhesion molecule 2. (537 aa)
TBK1TANK binding kinase 1. (690 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (111 aa)
COLEC11Collectin subfamily member 11. (280 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
LOC105826387Uncharacterized protein. (139 aa)
SLAMF6SLAM family member 6. (330 aa)
TRAFD1TRAF-type zinc finger domain containing 1. (519 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1039 aa)
OTOP1Otopetrin 1. (609 aa)
VAV1Vav guanine nucleotide exchange factor 1. (806 aa)
CEACAM1Uncharacterized protein. (523 aa)
UBE2KUbiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
TRIM62Tripartite motif containing 62. (475 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (607 aa)
CD96CD96 molecule. (566 aa)
CLEC12BC-type lectin domain family 12 member B. (207 aa)
SLC15A4Solute carrier family 15 member 4. (579 aa)
NLRC5NLR family CARD domain containing 5. (1812 aa)
C3Complement C3. (1551 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
ERAP1Aminopeptidase. (915 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (224 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
BANF1Barrier to autointegration factor 1. (89 aa)
ISG15ISG15 ubiquitin like modifier. (174 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1233 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
ADARAdenosine deaminase RNA specific. (1174 aa)
ENSPCOP00000011549Uncharacterized protein. (340 aa)
TTLL12Tubulin tyrosine ligase like 12. (643 aa)
NLRX1NLR family member X1. (975 aa)
VSIG4V-set and immunoglobulin domain containing 4. (399 aa)
IRF7Interferon regulatory factor 7. (383 aa)
FAM3AFamily with sequence similarity 3 member A. (238 aa)
LOC105824591AIG1-type G domain-containing protein. (312 aa)
STAT2Signal transducer and activator of transcription. (862 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (591 aa)
APOEApolipoprotein E. (314 aa)
LYARLy1 antibody reactive. (364 aa)
CLEC6AC-type lectin domain containing 6A. (158 aa)
RBM14RNA binding motif protein 14. (669 aa)
ENSPCOP00000009822Uncharacterized protein. (396 aa)
LOC105817821X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (689 aa)
ENSPCOP00000009677TFG domain-containing protein. (334 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (400 aa)
SYKSpleen associated tyrosine kinase. (637 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (661 aa)
IRF1Interferon regulatory factor. (324 aa)
CACTINCactin, spliceosome C complex subunit. (756 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
CDC37Cell division cycle 37. (376 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (653 aa)
RASGRP1RAS guanyl releasing protein 1. (827 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
FYNTyrosine-protein kinase. (537 aa)
ENSPCOP00000008287Uncharacterized protein. (126 aa)
CD226CD226 molecule. (335 aa)
MMP12Matrix metallopeptidase 12. (469 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
LOC105816653C-type lectin domain-containing protein. (108 aa)
SH2D1BSH2 domain containing 1B. (131 aa)
ZNFX1Zinc finger NFX1-type containing 1. (1916 aa)
TKFCTriokinase and FMN cyclase. (579 aa)
POLR3FDNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (316 aa)
GRNGranulin precursor. (591 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (588 aa)
TRIM5Uncharacterized protein. (482 aa)
LOC105826384Uncharacterized protein. (151 aa)
SLAMF8SLAM family member 8. (268 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
DCST1DC-STAMP domain containing 1. (706 aa)
MBL2Mannose binding lectin 2. (247 aa)
LOC105822732Uncharacterized protein. (245 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
PARP14Poly [ADP-ribose] polymerase. (1791 aa)
NONONon-POU domain containing octamer binding. (470 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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