STRINGSTRING
CHRNA7 CHRNA7 HSPB6 HSPB6 HMGA2 HMGA2 HYAL1 HYAL1 CTSH CTSH TGFBR2 TGFBR2 GRN GRN RHOB RHOB EMC10 EMC10 CELA1 CELA1 JCAD JCAD ZNF304 ZNF304 GATA2 GATA2 LOC105822640 LOC105822640 CYBB CYBB PRKD1 PRKD1 NFE2L2 NFE2L2 APLNR APLNR ENSPCOP00000002776 ENSPCOP00000002776 BTG1 BTG1 CCL24 CCL24 HIPK2 HIPK2 XBP1 XBP1 HMOX1 HMOX1 DLL1 DLL1 HIF1A HIF1A PDPK1 PDPK1 KDR KDR SMAD1 SMAD1 ITGA5 ITGA5 PAK4 PAK4 RAPGEF3 RAPGEF3 MTDH MTDH EMP2 EMP2 ITGB2 ITGB2 WNT5A WNT5A IL10 IL10 NINJ1 NINJ1 VEGFB VEGFB TEK TEK TBXA2R TBXA2R KLF4 KLF4 ZC3H12A ZC3H12A AQP1 AQP1 TLR3 TLR3 ENSPCOP00000009588 ENSPCOP00000009588 NOS3 NOS3 PGF PGF NODAL NODAL ANGPT4 ANGPT4 ANGPTL4 ANGPTL4 FGF1 FGF1 NTRK1 NTRK1 SPHK1 SPHK1 SERPINE1 SERPINE1 CHI3L1 CHI3L1 IL1B IL1B JMJD8 JMJD8 MDK MDK TJP1 TJP1 ANGPTL3 ANGPTL3 ENSPCOP00000012342 ENSPCOP00000012342 JUP JUP ADM2 ADM2 ERAP1 ERAP1 APELA APELA HK2 HK2 C3 C3 ISL1 ISL1 RRAS RRAS JAK1 JAK1 VASH2 VASH2 PRKD2 PRKD2 ENSPCOP00000014590 ENSPCOP00000014590 NR2E1 NR2E1 FLT1 FLT1 NRP1 NRP1 ITGB8 ITGB8 CX3CR1 CX3CR1 TIE1 TIE1 ANGPT2 ANGPT2 HGF HGF TNFSF12 TNFSF12 SFRP2 SFRP2 CDH5 CDH5 RAMP2 RAMP2 TNN TNN ENG ENG VEGFC VEGFC TMIGD2 TMIGD2 CXCR3 CXCR3 AGO2 AGO2 PTGIS PTGIS CYP1B1 CYP1B1 EMILIN2 EMILIN2 ACVRL1 ACVRL1 SMOC2 SMOC2 SASH1 SASH1 ENSPCOP00000023392 ENSPCOP00000023392 EMILIN1 EMILIN1 PKM PKM BMPER BMPER VEGFA VEGFA ADM ADM F3 F3 PLCG1 PLCG1 CXCL8 CXCL8 THBS1 THBS1 ENSPCOP00000025432 ENSPCOP00000025432 MYDGF MYDGF EPHA1 EPHA1 CD40 CD40 FOXC2 FOXC2 GHSR GHSR SP1 SP1 RTN4 RTN4 GATA6 GATA6 LOC105822688 LOC105822688 WARS2 WARS2 GATA4 GATA4 PTK2B PTK2B SIRT1 SIRT1 HIPK1 HIPK1 AGGF1 AGGF1 GHRL GHRL AKT3 AKT3 GDF2 GDF2 ECM1 ECM1 C5 C5 PRKCA PRKCA PRKCB PRKCB STAT3 STAT3 PIK3CD PIK3CD CCBE1 CCBE1 HSPB1 HSPB1 DDAH1 DDAH1 LRG1 LRG1 FGF2 FGF2 HPSE HPSE VEGFD VEGFD FGF18 FGF18 ENSPCOP00000031789 ENSPCOP00000031789 SIRT6 SIRT6 ETS1 ETS1 STIM1 STIM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHRNA7Uncharacterized protein. (531 aa)
HSPB6Heat shock protein family B (small) member 6; Belongs to the small heat shock protein (HSP20) family. (162 aa)
HMGA2Uncharacterized protein. (117 aa)
HYAL1Hyaluronidase. (435 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (336 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
GRNGranulin precursor. (591 aa)
RHOBRas homolog family member B. (196 aa)
EMC10ER membrane protein complex subunit 10. (261 aa)
CELA1Chymotrypsin like elastase 1; Belongs to the peptidase S1 family. (257 aa)
JCADJunctional cadherin 5 associated. (1332 aa)
ZNF304Zinc finger protein 304. (690 aa)
GATA2GATA binding protein 2. (445 aa)
LOC105822640Integrin beta; Belongs to the integrin beta chain family. (454 aa)
CYBBCytochrome b-245 beta chain. (533 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (860 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
ENSPCOP00000002776Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (330 aa)
BTG1BTG anti-proliferation factor 1. (171 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
HIPK2Homeodomain interacting protein kinase 2. (1187 aa)
XBP1BZIP domain-containing protein. (377 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1041 aa)
PAK4Non-specific serine/threonine protein kinase. (588 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
MTDHMetadherin. (580 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
ITGB2Integrin beta. (764 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
IL10Interleukin 10. (178 aa)
NINJ1Ninjurin 1. (152 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
TBXA2RThromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (343 aa)
KLF4Uncharacterized protein. (486 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (598 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
ENSPCOP00000009588Uncharacterized protein. (316 aa)
NOS3Nitric oxide synthase 3. (994 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (220 aa)
NODALNodal growth differentiation factor. (348 aa)
ANGPT4Angiopoietin 4. (499 aa)
ANGPTL4Angiopoietin like 4. (411 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
SPHK1Sphingosine kinase 1. (469 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (385 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
JMJD8Jumonji domain containing 8. (280 aa)
MDKMidkine. (143 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1768 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
ENSPCOP00000012342RING-type domain-containing protein. (80 aa)
JUPJunction plakoglobin. (745 aa)
ADM2Adrenomedullin 2. (148 aa)
ERAP1Aminopeptidase. (915 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
HK2Hexokinase 2. (841 aa)
C3Complement C3. (1551 aa)
ISL1ISL LIM homeobox 1. (349 aa)
RRASRAS related. (220 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
VASH2Vasohibin 2. (355 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
ENSPCOP00000014590Uncharacterized protein. (118 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (421 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (768 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (379 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1143 aa)
ANGPT2Angiopoietin 2. (496 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (703 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (249 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (786 aa)
RAMP2Receptor activity modifying protein 2. (179 aa)
TNNTenascin N. (1299 aa)
ENGEndoglin. (657 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (367 aa)
TMIGD2Transmembrane and immunoglobulin domain containing 2. (225 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (401 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (869 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
EMILIN2Elastin microfibril interfacer 2. (1061 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
SMOC2SPARC related modular calcium binding 2. (457 aa)
SASH1SAM and SH3 domain containing 1. (1248 aa)
ENSPCOP00000023392Uncharacterized protein. (157 aa)
EMILIN1Elastin microfibril interfacer 1. (1022 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
BMPERBMP binding endothelial regulator. (704 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
ADMAdrenomedullin. (182 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (294 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1304 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
THBS1Thrombospondin 1. (1185 aa)
ENSPCOP00000025432Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (747 aa)
MYDGFMyeloid derived growth factor. (173 aa)
EPHA1EPH receptor A1. (942 aa)
CD40CD40 molecule. (281 aa)
FOXC2Forkhead box C2. (503 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (364 aa)
SP1Sp1 transcription factor. (788 aa)
RTN4Reticulon. (1195 aa)
GATA6GATA binding protein 6. (593 aa)
LOC105822688Uncharacterized protein. (54 aa)
WARS2Tryptophanyl tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (360 aa)
GATA4GATA binding protein 4. (445 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (967 aa)
SIRT1Sirtuin 1. (743 aa)
HIPK1Homeodomain interacting protein kinase 1. (1131 aa)
AGGF1Uncharacterized protein. (717 aa)
GHRLGhrelin and obestatin prepropeptide. (116 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GDF2Growth differentiation factor 2. (427 aa)
ECM1Extracellular matrix protein 1. (570 aa)
C5Complement C5. (1527 aa)
PRKCAUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
STAT3Signal transducer and activator of transcription. (796 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CCBE1Collagen and calcium binding EGF domains 1. (408 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (206 aa)
DDAH1Dimethylarginine dimethylaminohydrolase 1. (285 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (394 aa)
HPSEHeparanase. (395 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (319 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ENSPCOP00000031789Uncharacterized protein. (227 aa)
SIRT6Sirtuin 6. (305 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
STIM1Stromal interaction molecule 1. (784 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
Server load: low (18%) [HD]