STRINGSTRING
ENSPCOP00000026845 ENSPCOP00000026845 FOS FOS DAXX DAXX TFAP4 TFAP4 ENSPCOP00000000202 ENSPCOP00000000202 ABCA3 ABCA3 BCKDHB BCKDHB IGFBP2 IGFBP2 LOC105820095 LOC105820095 TGFB2 TGFB2 PHB PHB TGFBR2 TGFBR2 ATP2B1 ATP2B1 SPP1 SPP1 DDX54 DDX54 CYBB CYBB ENSPCOP00000002148 ENSPCOP00000002148 PTGER2 PTGER2 KDM3A KDM3A ADTRP ADTRP FIBIN FIBIN FOSB FOSB NCOA4 NCOA4 ENSPCOP00000003318 ENSPCOP00000003318 AIFM1 AIFM1 BMP7 BMP7 POU4F2 POU4F2 ESR2 ESR2 WBP2 WBP2 NR4A3 NR4A3 NOTCH1 NOTCH1 AVPR1A AVPR1A AREG AREG MED1 MED1 TRIP4 TRIP4 ANXA1 ANXA1 PAQR8 PAQR8 SSTR2 SSTR2 DDX17 DDX17 RXRA RXRA UBR5 UBR5 TRIM63 TRIM63 TGFB3 TGFB3 ESRRA ESRRA ZMIZ1 ZMIZ1 OXT OXT TRERF1 TRERF1 LOC105822779 LOC105822779 PADI2 PADI2 RXRB RXRB AXIN2 AXIN2 PLPP1 PLPP1 IL10 IL10 IL6 IL6 ZFP36L2 ZFP36L2 PAPPA PAPPA ENSPCOP00000008878 ENSPCOP00000008878 AQP1 AQP1 PTGS2 PTGS2 NKX2-2 NKX2-2 RBFOX2 RBFOX2 ABHD2 ABHD2 IL1RN IL1RN ASS1 ASS1 HSD3B2 HSD3B2 ZFP36 ZFP36 PARP1 PARP1 YAP1 YAP1 GHRHR GHRHR DSG1 DSG1 PPARA PPARA MDK MDK ATP1A1 ATP1A1 ALPL ALPL TACR1 TACR1 TMF1 TMF1 ISL1 ISL1 SLIT2 SLIT2 CCN2 CCN2 ADIPOQ ADIPOQ GSK3A GSK3A SCNN1B SCNN1B NCOA2 NCOA2 UCP3 UCP3 PCSK1 PCSK1 HNRNPU HNRNPU ENSPCOP00000014253 ENSPCOP00000014253 TSPO TSPO MSTN MSTN NR3C1 NR3C1 SLIT3 SLIT3 ERRFI1 ERRFI1 TNF TNF URI1 URI1 NR2E1 NR2E1 STC1 STC1 PIK3CA PIK3CA PAM PAM SMYD3 SMYD3 PFKFB1 PFKFB1 METTL21C METTL21C FKBP4 FKBP4 ACVR1 ACVR1 UBE3A UBE3A MGARP MGARP PDCD7 PDCD7 FBXO32 FBXO32 CPN1 CPN1 NPC1 NPC1 SRC SRC ATP1A3 ATP1A3 ABCA2 ABCA2 LOX LOX DDIT4 DDIT4 SLC12A3 SLC12A3 RXRG RXRG CPS1 CPS1 CNGA3 CNGA3 COL1A1 COL1A1 PPP1R9B PPP1R9B SOX10 SOX10 BCL2 BCL2 CYP7B1 CYP7B1 ENG ENG ZFP36L1 ZFP36L1 DAB2 DAB2 GPR83 GPR83 IGF1R IGF1R NR2E3 NR2E3 CYP1B1 CYP1B1 TGFB1 TGFB1 DDX5 DDX5 ESR1 ESR1 NR1H3 NR1H3 TYMS TYMS CALCR CALCR PPARGC1B PPARGC1B SDC1 SDC1 SREBF1 SREBF1 GNRH1 GNRH1 BPIFB2 BPIFB2 ADM ADM CYBA CYBA FLT3 FLT3 BCL2L11 BCL2L11 TH TH ACR ACR THBS1 THBS1 FN1 FN1 ENSPCOP00000025005 ENSPCOP00000025005 CAV1 CAV1 ESRRG ESRRG NKX3-1 NKX3-1 ARID1A ARID1A ARG1 ARG1 HSD11B2 HSD11B2 MAOB MAOB ENSPCOP00000026233 ENSPCOP00000026233 IL22 IL22 YWHAH YWHAH ACSBG1 ACSBG1 GHSR GHSR CST11 CST11 REST REST EGLN2 EGLN2 PTPRU PTPRU PCK2 PCK2 PGR PGR USP8 USP8 BMP4 BMP4 BMP6 BMP6 HNF4A HNF4A AGL AGL SERPINF1 SERPINF1 PGRMC2 PGRMC2 SCNN1G SCNN1G CASP9 CASP9 HMGCS2 HMGCS2 FOSL1 FOSL1 RNF14 RNF14 GOT1 GOT1 CALCOCO1 CALCOCO1 BAD BAD PPARD PPARD POR POR MYOD1 MYOD1 TAT TAT ACOD1 ACOD1 NEDD4 NEDD4 RPS6KB1 RPS6KB1 NR1D1 NR1D1 CLDN1 CLDN1 GABRB1 GABRB1 ENSPCOP00000031233 ENSPCOP00000031233 NPAS4 NPAS4 ESRRB ESRRB ATP1A2 ATP1A2 STK39 STK39 SCGB2A1 SCGB2A1 SCGB1A1 SCGB1A1 AR AR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPCOP00000026845USP8_dimer domain-containing protein. (167 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
DAXXDeath domain associated protein. (739 aa)
TFAP4Transcription factor AP-4. (338 aa)
ENSPCOP00000000202Prohibitin. (262 aa)
ABCA3ATP binding cassette subfamily A member 3. (1703 aa)
BCKDHBBranched chain keto acid dehydrogenase E1 subunit beta. (363 aa)
IGFBP2Insulin like growth factor binding protein 2. (321 aa)
LOC105820095Uncharacterized protein. (784 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PHBProhibitin. (272 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
SPP1Secreted phosphoprotein 1. (305 aa)
DDX54ATP-dependent RNA helicase DDX54; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (872 aa)
CYBBCytochrome b-245 beta chain. (533 aa)
ENSPCOP00000002148Uncharacterized protein. (118 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (361 aa)
KDM3ALysine demethylase 3A. (1324 aa)
ADTRPAndrogen dependent TFPI regulating protein. (237 aa)
FIBINFin bud initiation factor homolog. (211 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
NCOA4Nuclear receptor coactivator 4. (650 aa)
ENSPCOP00000003318Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (114 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
POU4F2POU domain protein. (408 aa)
ESR2Estrogen receptor 2. (471 aa)
WBP2WW domain binding protein 2. (261 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (645 aa)
NOTCH1Notch receptor 1. (2420 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (410 aa)
AREGAmphiregulin. (253 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
TRIP4Thyroid hormone receptor interactor 4. (520 aa)
ANXA1Annexin. (346 aa)
PAQR8Progestin and adipoQ receptor family member 8. (354 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
DDX17DEAD-box helicase 17; Belongs to the DEAD box helicase family. (735 aa)
RXRARetinoid X receptor alpha. (469 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2776 aa)
TRIM63Tripartite motif containing 63. (354 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1067 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
TRERF1Transcriptional regulating factor 1. (1154 aa)
LOC105822779Uncharacterized protein. (325 aa)
PADI2Peptidyl arginine deiminase 2. (614 aa)
RXRBRetinoid X receptor beta. (535 aa)
AXIN2Axin 2. (716 aa)
PLPP1Phospholipid phosphatase 1. (286 aa)
IL10Interleukin 10. (178 aa)
IL6Uncharacterized protein. (211 aa)
ZFP36L2ZFP36 ring finger protein like 2. (493 aa)
PAPPAPappalysin 1. (1615 aa)
ENSPCOP00000008878Uncharacterized protein. (329 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
NKX2-2NK2 homeobox 2. (273 aa)
RBFOX2RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events. (400 aa)
ABHD2Abhydrolase domain containing 2. (457 aa)
IL1RNInterleukin-1. (177 aa)
ASS1Argininosuccinate synthase 1. (412 aa)
HSD3B23Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
ZFP36ZFP36 ring finger protein. (333 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
YAP1Uncharacterized protein. (504 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
DSG1Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1043 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
MDKMidkine. (143 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1023 aa)
ALPLAlkaline phosphatase. (524 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
TMF1TATA element modulatory factor 1. (780 aa)
ISL1ISL LIM homeobox 1. (349 aa)
SLIT2Slit guidance ligand 2. (1423 aa)
CCN2Cellular communication network factor 2. (347 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
SCNN1BSodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (663 aa)
NCOA2Nuclear receptor coactivator. (1465 aa)
UCP3Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (311 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (753 aa)
HNRNPUUncharacterized protein. (824 aa)
ENSPCOP00000014253RWD domain-containing protein. (195 aa)
TSPOTranslocator protein. (169 aa)
MSTNMyostatin. (376 aa)
NR3C1Nuclear receptor subfamily 3 group C member 1. (722 aa)
SLIT3Slit guidance ligand 3. (1523 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (460 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
URI1URI1 prefoldin like chaperone. (508 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (421 aa)
STC1Stanniocalcin 1. (247 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (695 aa)
SMYD3SET and MYND domain containing 3. (428 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
METTL21CMethyltransferase like 21C. (264 aa)
FKBP4Peptidylprolyl isomerase. (459 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (870 aa)
MGARPMitochondria localized glutamic acid rich protein. (240 aa)
PDCD7Programmed cell death 7. (484 aa)
FBXO32F-box protein 32. (355 aa)
CPN1Carboxypeptidase N subunit 1. (458 aa)
NPC1NPC intracellular cholesterol transporter 1. (1213 aa)
SRCTyrosine-protein kinase. (543 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1080 aa)
ABCA2ATP binding cassette subfamily A member 2. (2452 aa)
LOXLysyl oxidase. (416 aa)
DDIT4DNA damage inducible transcript 4. (230 aa)
SLC12A3Solute carrier family 12 member 3. (1027 aa)
RXRGRetinoid X receptor gamma. (463 aa)
CPS1Carbamoyl-phosphate synthase 1. (1310 aa)
CNGA3Cyclic nucleotide gated channel subunit alpha 3. (691 aa)
COL1A1Collagen type I alpha 1 chain. (1461 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (819 aa)
SOX10SRY-box transcription factor 10. (468 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (506 aa)
ENGEndoglin. (657 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
DAB2DAB adaptor protein 2. (769 aa)
GPR83G protein-coupled receptor 83; Belongs to the G-protein coupled receptor 1 family. (424 aa)
IGF1RTyrosine-protein kinase receptor. (1350 aa)
NR2E3Nuclear receptor subfamily 2 group E member 3. (410 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (599 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (454 aa)
TYMSThymidylate synthetase. (313 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (479 aa)
PPARGC1BPPARG coactivator 1 beta. (1010 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1180 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (92 aa)
BPIFB2BPI fold containing family B member 2. (457 aa)
ADMAdrenomedullin. (182 aa)
CYBACytochrome b-245 alpha chain. (129 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (949 aa)
BCL2L11BCL2 like 11. (200 aa)
THTyrosine hydroxylase. (497 aa)
ACRAcrosin; Belongs to the peptidase S1 family. (356 aa)
THBS1Thrombospondin 1. (1185 aa)
FN1Fibronectin 1. (2290 aa)
ENSPCOP00000025005Uncharacterized protein. (351 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
ESRRGEstrogen related receptor gamma. (470 aa)
NKX3-1NK3 homeobox 1. (226 aa)
ARID1AAT-rich interaction domain 1A. (2288 aa)
ARG1Arginase. (229 aa)
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (329 aa)
MAOBAmine oxidase. (528 aa)
ENSPCOP00000026233Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (177 aa)
IL22Interleukin 22. (179 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (723 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (364 aa)
CST11Cystatin 11. (138 aa)
RESTUncharacterized protein. (1018 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (405 aa)
PTPRUProtein tyrosine phosphatase receptor type U. (1446 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
PGRNuclear receptor domain-containing protein. (592 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1068 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
BMP6Bone morphogenetic protein 6. (509 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
AGLAmylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase. (1434 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
PGRMC2Progesterone receptor membrane component 2; Belongs to the cytochrome b5 family. (236 aa)
SCNN1GSodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (651 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (406 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (272 aa)
RNF14RBR-type E3 ubiquitin transferase. (422 aa)
GOT1Aspartate aminotransferase. (413 aa)
CALCOCO1Calcium binding and coiled-coil domain 1. (691 aa)
BADBCL2 associated agonist of cell death. (168 aa)
PPARDPeroxisome proliferator activated receptor delta. (440 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (681 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
ACOD1Aconitate decarboxylase 1. (478 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1320 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
GABRB1Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (474 aa)
ENSPCOP00000031233Uncharacterized protein. (318 aa)
NPAS4Neuronal PAS domain protein 4. (804 aa)
ESRRBEstrogen related receptor beta. (500 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
STK39Serine/threonine kinase 39. (522 aa)
SCGB2A1Secretoglobin family 2A member 1. (93 aa)
SCGB1A1Secretoglobin family 1A member 1. (91 aa)
ARAndrogen receptor. (886 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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