STRINGSTRING
NIPBL NIPBL NKX2-6 NKX2-6 EXT1 EXT1 ZIC3 ZIC3 OTC OTC PYY PYY EPHB3 EPHB3 SFRP2 SFRP2 SRC SRC ADA ADA CCDC40 CCDC40 ENSPCOP00000018033 ENSPCOP00000018033 AGR2 AGR2 KCNQ1 KCNQ1 HOXA5 HOXA5 BBS7 BBS7 HOXA13 HOXA13 PERCC1 PERCC1 TNF TNF ENSPCOP00000014834 ENSPCOP00000014834 CCDC39 CCDC39 EPB41L5 EPB41L5 HOXD13 HOXD13 EDNRB EDNRB NKX2-3 NKX2-3 CBFA2T2 CBFA2T2 ENSPCOP00000013017 ENSPCOP00000013017 IL6ST IL6ST GLI1 GLI1 YAP1 YAP1 CDX2 CDX2 ENSPCOP00000011221 ENSPCOP00000011221 SAV1 SAV1 RB1 RB1 PCSK5 PCSK5 ALX4 ALX4 NODAL NODAL ASS1 ASS1 KLF5 KLF5 NKX2-2 NKX2-2 C1GALT1 C1GALT1 FOXF1 FOXF1 PDGFC PDGFC SOX17 SOX17 CCKBR CCKBR GLI2 GLI2 WNT5A WNT5A STRA6 STRA6 TGFB3 TGFB3 CHD8 CHD8 ACVR2B ACVR2B FGF9 FGF9 WNT11 WNT11 OVOL2 OVOL2 HIF1A HIF1A NOTCH1 NOTCH1 HLX HLX TBX2 TBX2 MEGF8 MEGF8 PKD1 PKD1 TIGAR TIGAR GATA5 GATA5 IHH IHH PDX1 PDX1 CLDN18 CLDN18 TGFBR2 TGFBR2 TGFB2 TGFB2 FGF10 FGF10 PRDM1 PRDM1 GLI3 GLI3 COL3A1 COL3A1 SMAD2 SMAD2 SHOX2 SHOX2 DACT1 DACT1 TCF21 TCF21 MYOCD MYOCD TP63 TP63 SALL1 SALL1 SFRP1 SFRP1 LGR4 LGR4 VPS52 VPS52 FGFR2 FGFR2 SOX11 SOX11 CRKL CRKL SPDEF SPDEF HMGCS2 HMGCS2 SOX9 SOX9 ID2 ID2 ENSPCOP00000029049 ENSPCOP00000029049 BMP4 BMP4 SMO SMO GATA4 GATA4 GATA6 GATA6 ALDH1A2 ALDH1A2 SIX2 SIX2 YIPF6 YIPF6 ENSPCOP00000025005 ENSPCOP00000025005 CXCL8 CXCL8 CLMP CLMP NKX3-2 NKX3-2 MIXL1 MIXL1 KIT KIT RET RET TYMS TYMS TGFB1 TGFB1 PKDCC PKDCC CTNNB1 CTNNB1 RARB RARB SMAD3 SMAD3 SCT SCT IFT172 IFT172 BCL2 BCL2 SOX10 SOX10 CCDC103 CCDC103 FOXF2 FOXF2 CPS1 CPS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NIPBLNipped-B protein. (2673 aa)
NKX2-6NK2 homeobox 6. (296 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
ZIC3Zic family member 3. (466 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
PYYPeptide YY. (97 aa)
EPHB3EPH receptor B3. (1009 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
SRCTyrosine-protein kinase. (543 aa)
ADAAdenosine deaminase. (363 aa)
CCDC40Coiled-coil domain containing 40. (1123 aa)
ENSPCOP00000018033HH_signal domain-containing protein. (110 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (122 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (545 aa)
HOXA5Homeobox A5. (270 aa)
BBS7Bardet-Biedl syndrome 7. (674 aa)
HOXA13Homeobox A13. (366 aa)
PERCC1Uncharacterized protein. (259 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
ENSPCOP00000014834Cobl domain-containing protein. (394 aa)
CCDC39Coiled-coil domain containing 39. (841 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (731 aa)
HOXD13Homeobox D13. (347 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (485 aa)
NKX2-3NK2 homeobox 3. (361 aa)
CBFA2T2CBFA2/RUNX1 partner transcriptional co-repressor 2. (594 aa)
ENSPCOP00000013017Uncharacterized protein. (47 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
GLI1GLI family zinc finger 1. (1106 aa)
YAP1Uncharacterized protein. (504 aa)
CDX2Caudal type homeobox 2. (313 aa)
ENSPCOP00000011221FERM domain-containing protein. (471 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
RB1RB transcriptional corepressor 1. (787 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1858 aa)
ALX4ALX homeobox 4. (404 aa)
NODALNodal growth differentiation factor. (348 aa)
ASS1Argininosuccinate synthase 1. (412 aa)
KLF5Kruppel like factor 5. (457 aa)
NKX2-2NK2 homeobox 2. (273 aa)
C1GALT1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (355 aa)
FOXF1Forkhead box F1. (381 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (284 aa)
SOX17SRY-box transcription factor 17. (413 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (449 aa)
GLI2GLI family zinc finger 2. (1590 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
STRA6Stimulated by retinoic acid 6. (687 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2592 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (529 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
OVOL2Ovo like zinc finger 2. (276 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
NOTCH1Notch receptor 1. (2420 aa)
HLXH2.0 like homeobox. (487 aa)
TBX2T-box transcription factor 2. (713 aa)
MEGF8Multiple EGF like domains 8. (2804 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4265 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
GATA5GATA binding protein 5. (394 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PRDM1PR/SET domain 1. (789 aa)
GLI3GLI family zinc finger 3. (1580 aa)
COL3A1Collagen type III alpha 1 chain. (1371 aa)
SMAD2Mothers against decapentaplegic homolog. (462 aa)
SHOX2Short stature homeobox 2. (355 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (798 aa)
TCF21Transcription factor 21. (179 aa)
MYOCDMyocardin. (780 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
SALL1Spalt like transcription factor 1. (1315 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (920 aa)
VPS52VPS52 subunit of GARP complex. (723 aa)
FGFR2Fibroblast growth factor receptor. (797 aa)
SOX11Transcription factor SOX. (442 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
SOX9SRY-box transcription factor 9. (505 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
ENSPCOP00000029049Dynein assembly factor 1, axonemal. (298 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
GATA4GATA binding protein 4. (445 aa)
GATA6GATA binding protein 6. (593 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
SIX2SIX homeobox 2. (296 aa)
YIPF6Protein YIPF. (207 aa)
ENSPCOP00000025005Uncharacterized protein. (351 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CLMPCXADR like membrane protein. (377 aa)
NKX3-2NK3 homeobox 2. (333 aa)
MIXL1Mix paired-like homeobox. (232 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1079 aa)
TYMSThymidylate synthetase. (313 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (492 aa)
CTNNB1Catenin beta 1. (781 aa)
RARBRetinoic acid receptor beta. (448 aa)
SMAD3Mothers against decapentaplegic homolog. (443 aa)
SCTSecretin. (132 aa)
IFT172Intraflagellar transport 172. (1723 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
SOX10SRY-box transcription factor 10. (468 aa)
CCDC103Coiled-coil domain containing 103. (242 aa)
FOXF2Forkhead box F2. (405 aa)
CPS1Carbamoyl-phosphate synthase 1. (1310 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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