STRINGSTRING
TNF TNF PIK3CA PIK3CA MAP3K5 MAP3K5 MNAT1 MNAT1 CCN4 CCN4 ADAMTS1 ADAMTS1 SRC SRC DDR2 DDR2 FRS2 FRS2 IGF1 IGF1 LDLRAP1 LDLRAP1 CX3CL1 CX3CL1 ENSPCOP00000021101 ENSPCOP00000021101 ENSPCOP00000021175 ENSPCOP00000021175 RPS6KB1 RPS6KB1 PDGFRB PDGFRB FGFR2 FGFR2 NOX1 NOX1 IRAK1 IRAK1 ID2 ID2 IL6R IL6R MEF2D MEF2D AKT1 AKT1 NPY5R NPY5R IRAK4 IRAK4 GJA1 GJA1 BMP4 BMP4 S1PR1 S1PR1 ALOX12 ALOX12 ITGA2 ITGA2 NF1 NF1 ELANE ELANE ENSPCOP00000025432 ENSPCOP00000025432 ENSPCOP00000024480 ENSPCOP00000024480 CYBA CYBA VEGFA VEGFA EREG EREG FOXJ2 FOXJ2 TGFBR2 TGFBR2 PHB PHB SERPINF2 SERPINF2 IGFBP5 IGFBP5 ENSPCOP00000000202 ENSPCOP00000000202 THBS1 THBS1 ERN1 ERN1 TGFB1 TGFB1 IGF1R IGF1R NOTCH3 NOTCH3 NR4A3 NR4A3 HMOX1 HMOX1 XBP1 XBP1 MFN2 MFN2 PDGFB PDGFB ENSPCOP00000002776 ENSPCOP00000002776 LOC105822640 LOC105822640 SMPD3 SMPD3 CALCRL CALCRL FGF9 FGF9 HBEGF HBEGF EDN1 EDN1 MMP2 MMP2 STAT1 STAT1 IL6 IL6 HES5 HES5 AIF1 AIF1 PTGS2 PTGS2 FOXP1 FOXP1 BMPR1A BMPR1A MMP9 MMP9 DNMT1 DNMT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1317 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
CCN4Cellular communication network factor 4. (365 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (965 aa)
SRCTyrosine-protein kinase. (543 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
IGF1Insulin like growth factor 1. (208 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (308 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (405 aa)
ENSPCOP00000021101Uncharacterized protein. (86 aa)
ENSPCOP00000021175Uncharacterized protein. (354 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
FGFR2Fibroblast growth factor receptor. (797 aa)
NOX1NADPH oxidase 1. (564 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (713 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
IL6RInterleukin 6 receptor. (469 aa)
MEF2DMyocyte enhancer factor 2D. (519 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NPY5RNeuropeptide Y receptor Y5. (446 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (406 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1129 aa)
NF1Neurofibromin 1. (2841 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (268 aa)
ENSPCOP00000025432Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (747 aa)
ENSPCOP00000024480Uncharacterized protein. (103 aa)
CYBACytochrome b-245 alpha chain. (129 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
EREGEpiregulin. (166 aa)
FOXJ2Forkhead box J2. (527 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PHBProhibitin. (272 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (487 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
ENSPCOP00000000202Prohibitin. (262 aa)
THBS1Thrombospondin 1. (1185 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (935 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IGF1RTyrosine-protein kinase receptor. (1350 aa)
NOTCH3Notch receptor 3. (2318 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (645 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
XBP1BZIP domain-containing protein. (377 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ENSPCOP00000002776Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (330 aa)
LOC105822640Integrin beta; Belongs to the integrin beta chain family. (454 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (372 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
EDN1Endothelin 1. (193 aa)
MMP2Matrix metallopeptidase 2. (552 aa)
STAT1Signal transducer and activator of transcription. (794 aa)
IL6Uncharacterized protein. (211 aa)
HES5Orange domain-containing protein. (94 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
FOXP1Forkhead box P1. (693 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (484 aa)
MMP9Matrix metallopeptidase 9. (709 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1615 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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