STRINGSTRING
PTH1R PTH1R MITF MITF PTK2B PTK2B GJA1 GJA1 FOXC1 FOXC1 LRP5 LRP5 TIMP1 TIMP1 CCDC154 CCDC154 EDNRA EDNRA TCIRG1 TCIRG1 LGR4 LGR4 TNFSF11 TNFSF11 HIF1A HIF1A DLL4 DLL4 FLNA FLNA NOTCH2 NOTCH2 SPP2 SPP2 IHH IHH NOL3 NOL3 WNT16 WNT16 RAB3D RAB3D FGF10 FGF10 TRAF6 TRAF6 IGFBP5 IGFBP5 RASSF2 RASSF2 LIF LIF BMPR2 BMPR2 EFNA2 EFNA2 BSX BSX VDR VDR FGF8 FGF8 CSPG4 CSPG4 EPHA2 EPHA2 NOS3 NOS3 IL23A IL23A MEF2C MEF2C IL7 IL7 ATG5 ATG5 LIPA LIPA CELA1 CELA1 NFKB1 NFKB1 MMP2 MMP2 TGFB3 TGFB3 ACVR2B ACVR2B EPAS1 EPAS1 LRRK1 LRRK1 CHD7 CHD7 JAG1 JAG1 ACP5 ACP5 CTHRC1 CTHRC1 ENSPCOP00000016658 ENSPCOP00000016658 BAK1 BAK1 TIE1 TIE1 SRC SRC PTN PTN ELF3 ELF3 LTBP3 LTBP3 EXT1 EXT1 GDF5 GDF5 BAX BAX TPH1 TPH1 DBH DBH SNX10 SNX10 NCDN NCDN ATP7A ATP7A CTNNB1 CTNNB1 ACVRL1 ACVRL1 TGFB1 TGFB1 P3H4 P3H4 HNF1A HNF1A AXL AXL TPP1 TPP1 VEGFA VEGFA CAV1 CAV1 UMOD UMOD ARG1 ARG1 HOXA3 HOXA3 FOXC2 FOXC2 AGTR2 AGTR2 THBS4 THBS4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (590 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (967 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
FOXC1Forkhead box C1. (535 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
CCDC154Coiled-coil domain containing 154. (657 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (920 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (320 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
FLNAFilamin A. (2647 aa)
NOTCH2Notch receptor 2. (2471 aa)
SPP2Secreted phosphoprotein 2. (211 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
NOL3Nucleolar protein 3. (204 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
RAB3DRAB3D, member RAS oncogene family. (219 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TRAF6TNF receptor-associated factor. (498 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
RASSF2Ras association domain family member 2. (326 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (211 aa)
BSXBrain specific homeobox. (232 aa)
VDRVitamin D receptor. (474 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2322 aa)
EPHA2EPH receptor A2. (976 aa)
NOS3Nitric oxide synthase 3. (994 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
IL7Interleukin 7. (133 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
CELA1Chymotrypsin like elastase 1; Belongs to the peptidase S1 family. (257 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
MMP2Matrix metallopeptidase 2. (552 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (529 aa)
EPAS1Endothelial PAS domain protein 1. (869 aa)
LRRK1Leucine rich repeat kinase 1. (2012 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
CTHRC1Collagen triple helix repeat containing 1. (246 aa)
ENSPCOP00000016658Uncharacterized protein. (674 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1143 aa)
SRCTyrosine-protein kinase. (543 aa)
PTNPleiotrophin. (177 aa)
ELF3E74 like ETS transcription factor 3. (372 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1306 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
GDF5Growth differentiation factor 5. (499 aa)
BAXBCL2 associated X, apoptosis regulator. (199 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
DBHDopamine beta-hydroxylase. (620 aa)
SNX10Sorting nexin 10. (201 aa)
NCDNNeurochondrin. (729 aa)
ATP7AATPase copper transporting alpha. (1502 aa)
CTNNB1Catenin beta 1. (781 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
P3H4Prolyl 3-hydroxylase family member 4 (non-enzymatic). (443 aa)
HNF1AHNF1 homeobox A. (662 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
TPP1Tripeptidyl peptidase 1. (563 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
UMODUromodulin. (676 aa)
ARG1Arginase. (229 aa)
HOXA3Homeobox A3. (444 aa)
FOXC2Forkhead box C2. (503 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
THBS4Thrombospondin 4. (959 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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