(72 nodes) Presynaptic active zone network (Propithecus coquereli)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ATP2B1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
	ENSPCOP00000002072	C2 domain-containing protein. (239 aa)
	ADORA2A	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (411 aa)
	PPFIA2	PTPRF interacting protein alpha 2. (692 aa)
	ARHGAP44	Rho GTPase activating protein 44. (766 aa)
	CNTNAP1	Contactin associated protein 1. (1382 aa)
	GAD1	Glutamate decarboxylase 1. (594 aa)
	C1QBP	Uncharacterized protein. (281 aa)
	LOC105808538	t-SNARE coiled-coil homology domain-containing protein. (276 aa)
	STX4	Syntaxin 4; Belongs to the syntaxin family. (298 aa)
	CTBP1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (440 aa)
	PPFIA3	PTPRF interacting protein alpha 3. (1194 aa)
	RAB3A	RAB3A, member RAS oncogene family. (220 aa)
	UNC13A	Uncharacterized protein. (1721 aa)
	CDH10	Cadherin 10; Cadherins are calcium-dependent cell adhesion proteins. (446 aa)
	OTOF	Otoferlin. (1998 aa)
	ENSPCOP00000005855	Uncharacterized protein. (259 aa)
	TPRG1L	Tumor protein p63 regulated 1 like. (272 aa)
	SYP	Synaptophysin. (313 aa)
	NRG1	Neuregulin 1. (710 aa)
	ERC2	ELKS/RAB6-interacting/CAST family member 2. (957 aa)
	GUCY1B1	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (176 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	CPLX3	Complexin 3. (158 aa)
	PCLO	Piccolo presynaptic cytomatrix protein. (4274 aa)
	ZZEF1	Zinc finger ZZ-type and EF-hand domain containing 1. (2885 aa)
	SYT11	Synaptotagmin 11. (431 aa)
	SHANK2	SH3 and multiple ankyrin repeat domains 2. (1819 aa)
	APP	Amyloid beta precursor protein. (772 aa)
	ENSPCOP00000011521	C2 domain-containing protein. (135 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1229 aa)
	STX3	Syntaxin 3; Belongs to the syntaxin family. (290 aa)
	NRXN1	Neurexin 1. (1449 aa)
	SV2A	Synaptic vesicle glycoprotein 2A. (755 aa)
	PPFIA4	PTPRF interacting protein alpha 4. (1183 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1204 aa)
	RIMS4	Regulating synaptic membrane exocytosis 4. (277 aa)
	EGFLAM	EGF like, fibronectin type III and laminin G domains. (1017 aa)
	P2RX1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
	NUFIP1	Nuclear FMR1 interacting protein 1. (492 aa)
	NPTN	Uncharacterized protein. (399 aa)
	LRFN3	Leucine rich repeat and fibronectin type III domain containing 3. (626 aa)
	ENSPCOP00000017622	Uncharacterized protein. (122 aa)
	ERC1	ELKS/RAB6-interacting/CAST family member 1. (737 aa)
	RIMS2	Regulating synaptic membrane exocytosis 2. (1081 aa)
	CTBP2	C-terminal binding protein 2. (985 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (836 aa)
	BRSK1	BR serine/threonine kinase 1. (736 aa)
	NECTIN1	Nectin cell adhesion molecule 1. (516 aa)
	SYN1	Synapsin I. (702 aa)
	CTNND1	Catenin delta 1. (984 aa)
	STX2	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (278 aa)
	ATP2B2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	VPS11	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa)
	PPFIBP1	PPFIA binding protein 1. (953 aa)
	BSN	Bassoon presynaptic cytomatrix protein. (3923 aa)
	NTNG2	Netrin G2. (452 aa)
	SLC32A1	Solute carrier family 32 member 1. (526 aa)
	PNISR	PNN interacting serine and arginine rich protein. (814 aa)
	UNC13B	Uncharacterized protein. (4267 aa)
	NTNG1	Netrin G1. (542 aa)
	RIMS1	Regulating synaptic membrane exocytosis 1. (1692 aa)
	P2RY1	Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	SLC17A7	Solute carrier family 17 member 7. (573 aa)
	STX1A	Syntaxin 1A; Belongs to the syntaxin family. (288 aa)
	LOC105813679	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (744 aa)
	STX1B	Syntaxin 1B; Belongs to the syntaxin family. (291 aa)
	ENSPCOP00000029571	HNOB domain-containing protein. (173 aa)
	PPFIBP2	PPFIA binding protein 2. (874 aa)
	RIMS3	Regulating synaptic membrane exocytosis 3. (308 aa)
	PPFIA1	PTPRF interacting protein alpha 1. (1184 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADORA2A	P2RY1	ENSPCOP00000002230	ENSPCOP00000027770	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family.	0.865
APBA1	APP	ENSPCOP00000018346	ENSPCOP00000011346	Amyloid beta precursor protein binding family A member 1.	Amyloid beta precursor protein.	0.981
APBA1	ENSPCOP00000011521	ENSPCOP00000018346	ENSPCOP00000011521	Amyloid beta precursor protein binding family A member 1.	C2 domain-containing protein.	0.584
APBA1	LOC105808538	ENSPCOP00000018346	ENSPCOP00000003563	Amyloid beta precursor protein binding family A member 1.	t-SNARE coiled-coil homology domain-containing protein.	0.825
APBA1	NRXN1	ENSPCOP00000018346	ENSPCOP00000013084	Amyloid beta precursor protein binding family A member 1.	Neurexin 1.	0.612
APBA1	PPFIA1	ENSPCOP00000018346	ENSPCOP00000031820	Amyloid beta precursor protein binding family A member 1.	PTPRF interacting protein alpha 1.	0.634
APBA1	PPFIA2	ENSPCOP00000018346	ENSPCOP00000002424	Amyloid beta precursor protein binding family A member 1.	PTPRF interacting protein alpha 2.	0.579
APBA1	PPFIA3	ENSPCOP00000018346	ENSPCOP00000004903	Amyloid beta precursor protein binding family A member 1.	PTPRF interacting protein alpha 3.	0.699
APBA1	PPFIA4	ENSPCOP00000018346	ENSPCOP00000013896	Amyloid beta precursor protein binding family A member 1.	PTPRF interacting protein alpha 4.	0.579
APBA1	RAB3A	ENSPCOP00000018346	ENSPCOP00000005329	Amyloid beta precursor protein binding family A member 1.	RAB3A, member RAS oncogene family.	0.509
APBA1	RIMS1	ENSPCOP00000018346	ENSPCOP00000027254	Amyloid beta precursor protein binding family A member 1.	Regulating synaptic membrane exocytosis 1.	0.629
APBA1	RIMS2	ENSPCOP00000018346	ENSPCOP00000017737	Amyloid beta precursor protein binding family A member 1.	Regulating synaptic membrane exocytosis 2.	0.780
APBA1	RIMS3	ENSPCOP00000018346	ENSPCOP00000030630	Amyloid beta precursor protein binding family A member 1.	Regulating synaptic membrane exocytosis 3.	0.650
APBA1	RIMS4	ENSPCOP00000018346	ENSPCOP00000014378	Amyloid beta precursor protein binding family A member 1.	Regulating synaptic membrane exocytosis 4.	0.520
APBA1	STX1A	ENSPCOP00000018346	ENSPCOP00000028738	Amyloid beta precursor protein binding family A member 1.	Syntaxin 1A; Belongs to the syntaxin family.	0.928
APBA1	STX1B	ENSPCOP00000018346	ENSPCOP00000029395	Amyloid beta precursor protein binding family A member 1.	Syntaxin 1B; Belongs to the syntaxin family.	0.928
APBA1	STX2	ENSPCOP00000018346	ENSPCOP00000021058	Amyloid beta precursor protein binding family A member 1.	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.	0.825
APBA1	STX3	ENSPCOP00000018346	ENSPCOP00000012696	Amyloid beta precursor protein binding family A member 1.	Syntaxin 3; Belongs to the syntaxin family.	0.825
APBA1	STX4	ENSPCOP00000018346	ENSPCOP00000004363	Amyloid beta precursor protein binding family A member 1.	Syntaxin 4; Belongs to the syntaxin family.	0.825
APBA1	SYN1	ENSPCOP00000018346	ENSPCOP00000020263	Amyloid beta precursor protein binding family A member 1.	Synapsin I.	0.551