STRINGSTRING
ENSPCOP00000025379 ENSPCOP00000025379 ZP4 ZP4 ENSPCOP00000024882 ENSPCOP00000024882 VTCN1 VTCN1 AGER AGER IGFBP2 IGFBP2 EPHB2 EPHB2 TRAF6 TRAF6 FGF10 FGF10 TGFBR2 TGFBR2 NCK1 NCK1 SASH3 SASH3 PDCD1LG2 PDCD1LG2 TYK2 TYK2 NCK2 NCK2 CD80 CD80 JAK3 JAK3 CD38 CD38 ENSPCOP00000004985 ENSPCOP00000004985 HAVCR2 HAVCR2 PPP3CA PPP3CA ANXA1 ANXA1 LEP LEP TNFSF13B TNFSF13B IL12RB1 IL12RB1 TNFSF9 TNFSF9 ENSPCOP00000006834 ENSPCOP00000006834 HLA-DPA1 HLA-DPA1 IL6 IL6 CD274 CD274 AIF1 AIF1 PTPN22 PTPN22 IL7 IL7 MEF2C MEF2C CD70 CD70 CD40LG CD40LG CCDC88B CCDC88B SYK SYK IL23A IL23A BCL6 BCL6 CD74 CD74 GPAM GPAM TNFSF4 TNFSF4 IL12RB2 IL12RB2 PELI1 PELI1 IL1B IL1B CD3E CD3E CD81 CD81 ATAD5 ATAD5 IL6ST IL6ST TACR1 TACR1 IL12B IL12B SPTA1 SPTA1 CD28 CD28 NFATC2 NFATC2 CARD11 CARD11 IL12A IL12A CLCF1 CLCF1 CD1D CD1D VCAM1 VCAM1 CHRNB2 CHRNB2 FOXP3 FOXP3 ENSPCOP00000018033 ENSPCOP00000018033 IL15 IL15 ADA ADA NCKAP1L NCKAP1L IGF1 IGF1 VAV3 VAV3 CD320 CD320 ENSPCOP00000019705 ENSPCOP00000019705 CD86 CD86 BST1 BST1 ENSPCOP00000020030 ENSPCOP00000020030 ICOSLG ICOSLG SLAMF1 SLAMF1 BCL2 BCL2 TMIGD2 TMIGD2 IL27RA IL27RA FADD FADD PNP PNP KITLG KITLG TIRAP TIRAP CD276 CD276 MIF MIF CORO1A CORO1A CCL19 CCL19 DNAJA3 DNAJA3 ENSPCOP00000024480 ENSPCOP00000024480 RIPK2 RIPK2 EFNB1 EFNB1 DHPS DHPS RPS3 RPS3 IL23R IL23R LOC105819920 LOC105819920 PYCARD PYCARD SLC39A10 SLC39A10 TNFRSF4 TNFRSF4 IL2 IL2 MYD88 MYD88 IGF2 IGF2 RASAL3 RASAL3 BTK BTK TCF3 TCF3 ZNF335 ZNF335 CD6 CD6 ENSPCOP00000027398 ENSPCOP00000027398 PRKCQ PRKCQ ZAP70 ZAP70 TFRC TFRC TICAM1 TICAM1 TNFRSF13C TNFRSF13C CD40 CD40 SLC7A1 SLC7A1 MPL MPL IL21 IL21 WNT3A WNT3A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPCOP00000025379Uncharacterized protein. (532 aa)
ZP4Zona pellucida glycoprotein 4. (536 aa)
ENSPCOP00000024882Ribosomal_S3_C domain-containing protein. (231 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (282 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
IGFBP2Insulin like growth factor binding protein 2. (321 aa)
EPHB2EPH receptor B2. (1039 aa)
TRAF6TNF receptor-associated factor. (498 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
NCK1Cytoplasmic protein. (377 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (274 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
NCK2Cytoplasmic protein. (380 aa)
CD80CD80 molecule. (265 aa)
JAK3Tyrosine-protein kinase. (1123 aa)
CD38CD38 molecule. (290 aa)
ENSPCOP00000004985Uncharacterized protein. (330 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (272 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ANXA1Annexin. (346 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (244 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (665 aa)
TNFSF9TNF superfamily member 9; Belongs to the tumor necrosis factor family. (255 aa)
ENSPCOP00000006834Uncharacterized protein. (78 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
IL6Uncharacterized protein. (211 aa)
CD274CD274 molecule. (244 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (653 aa)
IL7Interleukin 7. (133 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
CD70TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (183 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
CCDC88BCoiled-coil domain containing 88B. (1474 aa)
SYKSpleen associated tyrosine kinase. (637 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
BCL6BCL6 transcription repressor. (706 aa)
CD74CD74 molecule. (298 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (787 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (178 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (780 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
CD3ECD3e molecule. (187 aa)
CD81Tetraspanin. (271 aa)
ATAD5ATPase family AAA domain containing 5. (1646 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2421 aa)
CD28CD28 molecule. (220 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
CARD11Caspase recruitment domain family member 11. (1125 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
CLCF1Cardiotrophin like cytokine factor 1. (225 aa)
CD1DCD1d molecule. (337 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (502 aa)
FOXP3Forkhead box P3. (433 aa)
ENSPCOP00000018033HH_signal domain-containing protein. (110 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (135 aa)
ADAAdenosine deaminase. (363 aa)
NCKAP1LNCK associated protein 1 like. (1138 aa)
IGF1Insulin like growth factor 1. (208 aa)
VAV3Vav guanine nucleotide exchange factor 3. (765 aa)
CD320CD320 molecule. (259 aa)
ENSPCOP00000019705Uncharacterized protein. (583 aa)
CD86CD86 molecule. (336 aa)
BST1Bone marrow stromal cell antigen 1. (329 aa)
ENSPCOP00000020030KH type-2 domain-containing protein. (93 aa)
ICOSLGUncharacterized protein. (299 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (368 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
TMIGD2Transmembrane and immunoglobulin domain containing 2. (225 aa)
IL27RAInterleukin 27 receptor subunit alpha. (637 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (205 aa)
PNPPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
TIRAPTIR domain containing adaptor protein. (198 aa)
CD276CD276 molecule. (332 aa)
MIFUncharacterized protein. (115 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
CCL19C-C motif chemokine. (108 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (429 aa)
ENSPCOP00000024480Uncharacterized protein. (103 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (539 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
DHPSUncharacterized protein. (369 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
IL23RInterleukin 23 receptor. (602 aa)
LOC105819920Uncharacterized protein. (116 aa)
PYCARDPYD and CARD domain containing. (195 aa)
SLC39A10Solute carrier family 39 member 10. (833 aa)
TNFRSF4TNF receptor superfamily member 4. (280 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
MYD88MYD88 innate immune signal transduction adaptor. (353 aa)
IGF2Insulin like growth factor 2. (236 aa)
RASAL3RAS protein activator like 3. (1012 aa)
BTKTyrosine-protein kinase. (647 aa)
TCF3Transcription factor 3. (655 aa)
ZNF335Zinc finger protein 335. (1347 aa)
CD6CD6 molecule. (670 aa)
ENSPCOP00000027398KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (281 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
ZAP70Tyrosine-protein kinase. (617 aa)
TFRCTransferrin receptor. (760 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (692 aa)
TNFRSF13CTNF receptor superfamily member 13C. (179 aa)
CD40CD40 molecule. (281 aa)
SLC7A1Solute carrier family 7 member 1. (629 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (634 aa)
IL21Interleukin 21. (110 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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