STRINGSTRING
LIMS2 LIMS2 PDX1 PDX1 DRD2 DRD2 SFRP2 SFRP2 GDF5 GDF5 ZEB1 ZEB1 DAB2IP DAB2IP STK3 STK3 FBXW7 FBXW7 AQP11 AQP11 ENG ENG DAB2 DAB2 CDC73 CDC73 IFT172 IFT172 ATOH8 ATOH8 ENSPCOP00000021909 ENSPCOP00000021909 HPN HPN IL26 IL26 PTCH1 PTCH1 IFT74 IFT74 B2M B2M KRIT1 KRIT1 ACVRL1 ACVRL1 TGFB1 TGFB1 EREG EREG FLCN FLCN RUNX3 RUNX3 NLRC3 NLRC3 THBS1 THBS1 CAV1 CAV1 NKX3-1 NKX3-1 DUSP10 DUSP10 TNMD TNMD CASK CASK ATF2 ATF2 NF1 NF1 CDK6 CDK6 GAS1 GAS1 CAV2 CAV2 CDKN1B CDKN1B CDKN1C CDKN1C GHRL GHRL BMP4 BMP4 SYNJ2BP SYNJ2BP GDF2 GDF2 PDCD10 PDCD10 SERPINF1 SERPINF1 LOC105816957 LOC105816957 CDKN2B CDKN2B PAX6 PAX6 SOX9 SOX9 EAF2 EAF2 OVOL1 OVOL1 FGFR2 FGFR2 SFRP1 SFRP1 PPARD PPARD ATP5IF1 ATP5IF1 MTSS1 MTSS1 VASH1 VASH1 TGFBR1 TGFBR1 AR AR MEN1 MEN1 IFT57 IFT57 PHOX2B PHOX2B IFT80 IFT80 LOC105821449 LOC105821449 PRL PRL FLT1 FLT1 TGFBR3 TGFBR3 RGCC RGCC IL12A IL12A SPARC SPARC ALOX5 ALOX5 TNF TNF DLG1 DLG1 TRIM24 TRIM24 MAGED1 MAGED1 ENSPCOP00000014764 ENSPCOP00000014764 IRF6 IRF6 NGFR NGFR CEACAM1 CEACAM1 STK4 STK4 CNMD CNMD NKX2-8 NKX2-8 ISL1 ISL1 VDR VDR IL12B IL12B KDF1 KDF1 B4GALT1 B4GALT1 NFIB NFIB SAV1 SAV1 IFT52 IFT52 RB1 RB1 ATP5F1A ATP5F1A ENSPCOP00000010769 ENSPCOP00000010769 INTU INTU APOE APOE WDR77 WDR77 COL4A3 COL4A3 MEF2C MEF2C GATA3 GATA3 SNAI2 SNAI2 PTPRM PTPRM XDH XDH BRCA2 BRCA2 MCC MCC STAT1 STAT1 CD109 CD109 WNT5A WNT5A RIDA RIDA A4GNT A4GNT RAP1GAP RAP1GAP TBC1D31 TBC1D31 MED1 MED1 ROBO1 ROBO1 NOTCH1 NOTCH1 SLURP1 SLURP1 DLL4 DLL4 STK11 STK11 WDR13 WDR13 KRT4 KRT4 MMRN2 MMRN2 EFNB2 EFNB2 TINF2 TINF2 AIMP1 AIMP1 SULF1 SULF1 TGFB2 TGFB2 PTEN PTEN WNT10B WNT10B SFN SFN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (366 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
GDF5Growth differentiation factor 5. (499 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1002 aa)
DAB2IPDAB2 interacting protein. (1209 aa)
STK3Serine/threonine kinase 3. (500 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
ENGEndoglin. (657 aa)
DAB2DAB adaptor protein 2. (769 aa)
CDC73Cell division cycle 73. (429 aa)
IFT172Intraflagellar transport 172. (1723 aa)
ATOH8Atonal bHLH transcription factor 8. (313 aa)
ENSPCOP00000021909Uncharacterized protein. (118 aa)
HPNPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (417 aa)
IL26Interleukin 26. (171 aa)
PTCH1Patched 1. (1449 aa)
IFT74Intraflagellar transport 74. (445 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (120 aa)
KRIT1ANK_REP_REGION domain-containing protein. (723 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
EREGEpiregulin. (166 aa)
FLCNFolliculin. (579 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (433 aa)
NLRC3NLR family CARD domain containing 3. (1103 aa)
THBS1Thrombospondin 1. (1185 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
NKX3-1NK3 homeobox 1. (226 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
TNMDTenomodulin. (320 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (915 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
NF1Neurofibromin 1. (2841 aa)
CDK6Cyclin dependent kinase 6. (263 aa)
GAS1Growth arrest specific 1. (340 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (263 aa)
GHRLGhrelin and obestatin prepropeptide. (116 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SYNJ2BPSynaptojanin 2 binding protein. (134 aa)
GDF2Growth differentiation factor 2. (427 aa)
PDCD10Programmed cell death 10. (186 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
LOC105816957Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (424 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
PAX6Paired box 6. (453 aa)
SOX9SRY-box transcription factor 9. (505 aa)
EAF2ELL associated factor 2. (263 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
FGFR2Fibroblast growth factor receptor. (797 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
PPARDPeroxisome proliferator activated receptor delta. (440 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (106 aa)
MTSS1MTSS I-BAR domain containing 1. (759 aa)
VASH1Vasohibin 1. (363 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (421 aa)
ARAndrogen receptor. (886 aa)
MEN1Menin 1. (616 aa)
IFT57Intraflagellar transport 57. (389 aa)
PHOX2BPaired like homeobox 2B. (305 aa)
IFT80Intraflagellar transport 80. (721 aa)
LOC105821449Uncharacterized protein. (111 aa)
PRLProlactin. (231 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
RGCCRegulator of cell cycle. (137 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
ALOX5Arachidonate 5-lipoxygenase. (675 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (910 aa)
TRIM24Tripartite motif containing 24. (984 aa)
MAGED1MAGE family member D1. (839 aa)
ENSPCOP00000014764Uncharacterized protein. (428 aa)
IRF6Interferon regulatory factor 6. (467 aa)
NGFRNerve growth factor receptor. (429 aa)
CEACAM1Uncharacterized protein. (523 aa)
STK4Serine/threonine kinase 4. (487 aa)
CNMDChondromodulin. (287 aa)
NKX2-8NK2 homeobox 8. (237 aa)
ISL1ISL LIM homeobox 1. (349 aa)
VDRVitamin D receptor. (474 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
KDF1Keratinocyte differentiation factor 1. (395 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
IFT52ABC_transp_aux domain-containing protein. (437 aa)
RB1RB transcriptional corepressor 1. (787 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (571 aa)
ENSPCOP00000010769Ig-like domain-containing protein. (119 aa)
INTUInturned planar cell polarity protein. (942 aa)
APOEApolipoprotein E. (314 aa)
WDR77WD repeat domain 77. (293 aa)
COL4A3Collagen type IV alpha 3 chain. (1545 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
GATA3Uncharacterized protein. (444 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1440 aa)
XDHXanthine dehydrogenase. (1313 aa)
BRCA2BRCA2 DNA repair associated. (3419 aa)
MCCMCC regulator of WNT signaling pathway. (825 aa)
STAT1Signal transducer and activator of transcription. (794 aa)
CD109CD109 molecule. (1359 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
RIDAUncharacterized protein. (137 aa)
A4GNTAlpha-1,4-N-acetylglucosaminyltransferase. (341 aa)
RAP1GAPRAP1 GTPase activating protein. (748 aa)
TBC1D31TBC1 domain family member 31. (1062 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
ROBO1Uncharacterized protein. (1334 aa)
NOTCH1Notch receptor 1. (2420 aa)
SLURP1Secreted LY6/PLAUR domain containing 1. (101 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
WDR13WD repeat domain 13. (485 aa)
KRT4Keratin 4; Belongs to the intermediate filament family. (522 aa)
MMRN2Multimerin 2. (948 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (335 aa)
TINF2TERF1 interacting nuclear factor 2. (451 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (283 aa)
SULF1Sulfatase 1. (863 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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