STRINGSTRING
ITGA5 ITGA5 ENSPCOP00000019705 ENSPCOP00000019705 FBXW7 FBXW7 BANK1 BANK1 HPX HPX IFNG IFNG PAK2 PAK2 CTF1 CTF1 UNC119 UNC119 ENSPCOP00000021694 ENSPCOP00000021694 ANGPT1 ANGPT1 NTF3 NTF3 OSBP OSBP KITLG KITLG ALKAL1 ALKAL1 GPRC5B GPRC5B IL20 IL20 PLPP3 PLPP3 PARP9 PARP9 PIBF1 PIBF1 ACE ACE TGFB1 TGFB1 EREG EREG EHD4 EHD4 GFRA1 GFRA1 TNK2 TNK2 MIF MIF KIT KIT DOK7 DOK7 LTK LTK VEGFA VEGFA FLT3 FLT3 ENSPCOP00000024480 ENSPCOP00000024480 FBXW9 FBXW9 RIPK2 RIPK2 RELN RELN LYN LYN LRP8 LRP8 WNT3A WNT3A IL21 IL21 IL31RA IL31RA ENSPCOP00000026048 ENSPCOP00000026048 DOCK3 DOCK3 CD40 CD40 FGF7 FGF7 CSF1R CSF1R CD44 CD44 THBS4 THBS4 ERBB3 ERBB3 TNFRSF1A TNFRSF1A PTK2B PTK2B FGFR3 FGFR3 GHRL GHRL BMP6 BMP6 NOD2 NOD2 IL6R IL6R AGT AGT ENSPCOP00000029403 ENSPCOP00000029403 PTPN11 PTPN11 EFNA5 EFNA5 ADAM17 ADAM17 IGF2 IGF2 RICTOR RICTOR TDGF1 TDGF1 IL2 IL2 CSF3 CSF3 LOC105819920 LOC105819920 LRP4 LRP4 LOC105809231 LOC105809231 IGF1 IGF1 ENSPCOP00000019163 ENSPCOP00000019163 BTC BTC SRC SRC EGFR EGFR HGF HGF IL15 IL15 TNFSF18 TNFSF18 IL4 IL4 DLG4 DLG4 NRP1 NRP1 ENSPCOP00000016892 ENSPCOP00000016892 ACVR1 ACVR1 CLCF1 CLCF1 IL12A IL12A EPGN EPGN CNTN1 CNTN1 MLST8 MLST8 CASS4 CASS4 EFNA1 EFNA1 DLG3 DLG3 TNFRSF14 TNFRSF14 EGF EGF CNTF CNTF ENSPCOP00000014002 ENSPCOP00000014002 HSF1 HSF1 ADIPOQ ADIPOQ ISL1 ISL1 FGF8 FGF8 IL12B IL12B PTPRJ PTPRJ TREM2 TREM2 LOC105822566 LOC105822566 NEDD9 NEDD9 IL6ST IL6ST PLCG2 PLCG2 CD81 CD81 CSPG4 CSPG4 SEMA4D SEMA4D CD3E CD3E CD36 CD36 CSF2 CSF2 ARHGEF2 ARHGEF2 ANGPT4 ANGPT4 CLEC6A CLEC6A ENSPCOP00000009718 ENSPCOP00000009718 LOC105821782 LOC105821782 CD74 CD74 IL23A IL23A SYK SYK IL24 IL24 PTPN1 PTPN1 CD4 CD4 NRG1 NRG1 HES5 HES5 VEGFB VEGFB FYN FYN TNFRSF18 TNFRSF18 IL6 IL6 ABI1 ABI1 STAP1 STAP1 NEURL1 NEURL1 ENPP2 ENPP2 NCF1 NCF1 TGFA TGFA LOC105806750 LOC105806750 ENSPCOP00000006834 ENSPCOP00000006834 IL5 IL5 ADNP ADNP DVL2 DVL2 ERCC6 ERCC6 HAX1 HAX1 HBEGF HBEGF LRRK1 LRRK1 EPO EPO PARP14 PARP14 LOC105822640 LOC105822640 TSLP TSLP MTOR MTOR FGF10 FGF10 ALKAL2 ALKAL2 ENSPCOP00000000722 ENSPCOP00000000722 OSM OSM GAS6 GAS6 SH2D1B SH2D1B LIF LIF GATA1 GATA1 IL23R IL23R TP53 TP53 GRM5 GRM5 ADRA1A ADRA1A LOC105823083 LOC105823083 ALK ALK HTR2A HTR2A CRLF1 CRLF1 AREG AREG AFAP1L2 AFAP1L2 ARL2BP ARL2BP CD80 CD80 PDGFB PDGFB DGKQ DGKQ SRCIN1 SRCIN1 PECAM1 PECAM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1041 aa)
ENSPCOP00000019705Uncharacterized protein. (583 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (567 aa)
HPXHemopexin. (466 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PAK2Non-specific serine/threonine protein kinase. (492 aa)
CTF1Cardiotrophin 1. (197 aa)
UNC119Unc-119 lipid binding chaperone. (240 aa)
ENSPCOP00000021694Uncharacterized protein. (146 aa)
ANGPT1Angiopoietin 1. (408 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (798 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
ALKAL1ALK and LTK ligand 1. (131 aa)
GPRC5BG protein-coupled receptor class C group 5 member B. (404 aa)
IL20Interleukin 20. (126 aa)
PLPP3acidPPc domain-containing protein. (312 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (857 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (663 aa)
ACEAngiotensin-converting enzyme. (1308 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
EREGEpiregulin. (166 aa)
EHD4EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (541 aa)
GFRA1GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (468 aa)
TNK2Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1088 aa)
MIFUncharacterized protein. (115 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
DOK7Docking protein 7. (500 aa)
LTKTyrosine-protein kinase receptor. (888 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (949 aa)
ENSPCOP00000024480Uncharacterized protein. (103 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (539 aa)
RELNReelin. (3445 aa)
LYNTyrosine-protein kinase. (512 aa)
LRP8LDL receptor related protein 8. (956 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
IL21Interleukin 21. (110 aa)
IL31RAInterleukin 31 receptor A. (642 aa)
ENSPCOP00000026048ARL2_Bind_BART domain-containing protein. (109 aa)
DOCK3Dedicator of cytokinesis 3; Belongs to the DOCK family. (1899 aa)
CD40CD40 molecule. (281 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
CD44CD44 molecule (Indian blood group). (746 aa)
THBS4Thrombospondin 4. (959 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1337 aa)
TNFRSF1ATNF receptor superfamily member 1A. (447 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (967 aa)
FGFR3Fibroblast growth factor receptor. (807 aa)
GHRLGhrelin and obestatin prepropeptide. (116 aa)
BMP6Bone morphogenetic protein 6. (509 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
IL6RInterleukin 6 receptor. (469 aa)
AGTAngiotensinogen; Belongs to the serpin family. (484 aa)
ENSPCOP00000029403Protein kinase domain-containing protein. (429 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
ADAM17ADAM metallopeptidase domain 17. (757 aa)
IGF2Insulin like growth factor 2. (236 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1646 aa)
TDGF1Teratocarcinoma-derived growth factor 1. (186 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
CSF3Colony stimulating factor 3. (199 aa)
LOC105819920Uncharacterized protein. (116 aa)
LRP4LDL receptor related protein 4. (1922 aa)
LOC105809231Ig-like domain-containing protein. (264 aa)
IGF1Insulin like growth factor 1. (208 aa)
ENSPCOP00000019163Ig-like domain-containing protein. (217 aa)
BTCBetacellulin. (140 aa)
SRCTyrosine-protein kinase. (543 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (703 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (135 aa)
TNFSF18TNF superfamily member 18. (199 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
DLG4Uncharacterized protein; Belongs to the MAGUK family. (602 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ENSPCOP00000016892ARL2_Bind_BART domain-containing protein. (150 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
CLCF1Cardiotrophin like cytokine factor 1. (225 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
EPGNEpithelial mitogen. (153 aa)
CNTN1Contactin 1. (1018 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
CASS4Cas scaffold protein family member 4. (774 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (849 aa)
TNFRSF14TNF receptor superfamily member 14. (267 aa)
EGFEpidermal growth factor. (1132 aa)
CNTFCiliary neurotrophic factor. (198 aa)
ENSPCOP00000014002Uncharacterized protein. (286 aa)
HSF1Heat shock transcription factor 1. (531 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
ISL1ISL LIM homeobox 1. (349 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1223 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (224 aa)
LOC105822566Uncharacterized protein. (223 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (834 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1233 aa)
CD81Tetraspanin. (271 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2322 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
CD3ECD3e molecule. (187 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
CSF2Colony stimulating factor 2. (146 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1013 aa)
ANGPT4Angiopoietin 4. (499 aa)
CLEC6AC-type lectin domain containing 6A. (158 aa)
ENSPCOP00000009718ARL2_Bind_BART domain-containing protein. (80 aa)
LOC105821782Uncharacterized protein. (380 aa)
CD74CD74 molecule. (298 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
SYKSpleen associated tyrosine kinase. (637 aa)
IL24Interleukin 24. (220 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
CD4CD4 molecule. (452 aa)
NRG1Neuregulin 1. (710 aa)
HES5Orange domain-containing protein. (94 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
FYNTyrosine-protein kinase. (537 aa)
TNFRSF18Uncharacterized protein. (236 aa)
IL6Uncharacterized protein. (211 aa)
ABI1Abl interactor 1. (508 aa)
STAP1Signal transducing adaptor family member 1. (227 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (911 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
TGFATransforming growth factor alpha. (190 aa)
LOC105806750Uncharacterized protein. (261 aa)
ENSPCOP00000006834Uncharacterized protein. (78 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (133 aa)
ADNPActivity dependent neuroprotector homeobox. (1102 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1488 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (278 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
LRRK1Leucine rich repeat kinase 1. (2012 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (194 aa)
PARP14Poly [ADP-ribose] polymerase. (1791 aa)
LOC105822640Integrin beta; Belongs to the integrin beta chain family. (454 aa)
TSLPThymic stromal lymphopoietin. (158 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ALKAL2Uncharacterized protein. (91 aa)
ENSPCOP00000000722Protein kinase domain-containing protein. (67 aa)
OSMOncostatin M. (251 aa)
GAS6Growth arrest specific 6. (648 aa)
SH2D1BSH2 domain containing 1B. (131 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
GATA1GATA binding protein 1. (413 aa)
IL23RInterleukin 23 receptor. (602 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
GRM5Glutamate metabotropic receptor 5. (1211 aa)
ADRA1AAdrenoceptor alpha 1A. (466 aa)
LOC105823083Uncharacterized protein. (215 aa)
ALKTyrosine-protein kinase receptor. (1578 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
CRLF1Cytokine receptor like factor 1. (437 aa)
AREGAmphiregulin. (253 aa)
AFAP1L2Actin filament associated protein 1 like 2. (818 aa)
ARL2BPARL2_Bind_BART domain-containing protein. (163 aa)
CD80CD80 molecule. (265 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
DGKQDiacylglycerol kinase. (939 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1347 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (698 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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