node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKT1 | APOE | ENSPCOP00000028969 | ENSPCOP00000010240 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Apolipoprotein E. | 0.451 |
AKT1 | ENSPCOP00000002776 | ENSPCOP00000028969 | ENSPCOP00000002776 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.564 |
AKT1 | ENSPCOP00000025432 | ENSPCOP00000028969 | ENSPCOP00000025432 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.564 |
AKT1 | ESR1 | ENSPCOP00000028969 | ENSPCOP00000023297 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.621 |
AKT1 | HIF1A | ENSPCOP00000028969 | ENSPCOP00000004706 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Hypoxia inducible factor 1 subunit alpha. | 0.680 |
AKT1 | PIK3CB | ENSPCOP00000028969 | ENSPCOP00000016466 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. | 0.952 |
AKT1 | PTK2B | ENSPCOP00000028969 | ENSPCOP00000027938 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.571 |
APOE | AKT1 | ENSPCOP00000010240 | ENSPCOP00000028969 | Apolipoprotein E. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.451 |
APOE | SCARB1 | ENSPCOP00000010240 | ENSPCOP00000006165 | Apolipoprotein E. | Scavenger receptor class B member 1; Belongs to the CD36 family. | 0.608 |
ENSPCOP00000002776 | AKT1 | ENSPCOP00000002776 | ENSPCOP00000028969 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.564 |
ENSPCOP00000002776 | ENSPCOP00000025432 | ENSPCOP00000002776 | ENSPCOP00000025432 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.942 |
ENSPCOP00000002776 | TERF2 | ENSPCOP00000002776 | ENSPCOP00000020164 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Telomeric repeat binding factor 2. | 0.603 |
ENSPCOP00000025432 | AKT1 | ENSPCOP00000025432 | ENSPCOP00000028969 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.564 |
ENSPCOP00000025432 | ENSPCOP00000002776 | ENSPCOP00000025432 | ENSPCOP00000002776 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.942 |
ENSPCOP00000025432 | TERF2 | ENSPCOP00000025432 | ENSPCOP00000020164 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Telomeric repeat binding factor 2. | 0.603 |
ESR1 | AKT1 | ENSPCOP00000023297 | ENSPCOP00000028969 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.621 |
ESR1 | HIF1A | ENSPCOP00000023297 | ENSPCOP00000004706 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Hypoxia inducible factor 1 subunit alpha. | 0.729 |
ESR1 | PIK3CB | ENSPCOP00000023297 | ENSPCOP00000016466 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. | 0.610 |
ESR1 | PTK2B | ENSPCOP00000023297 | ENSPCOP00000027938 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.641 |
GCH1 | NUS1 | ENSPCOP00000001831 | ENSPCOP00000017531 | GTP cyclohydrolase 1. | NUS1 dehydrodolichyl diphosphate synthase subunit. | 0.445 |