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BMP3 BMP3 MMP13 MMP13 SHOX2 SHOX2 BARX2 BARX2 FGF18 FGF18 IMPAD1 IMPAD1 WNT5B WNT5B FGF4 FGF4 BMP2 BMP2 TRPV4 TRPV4 SNX19 SNX19 MSX1 MSX1 SOX9 SOX9 MEF2D MEF2D ECM1 ECM1 HOXC4 HOXC4 THRA THRA MUSTN1 MUSTN1 GDF2 GDF2 MEX3C MEX3C BMP6 BMP6 BMP4 BMP4 GHRL GHRL COL11A2 COL11A2 FGFR3 FGFR3 OSR2 OSR2 HAND1 HAND1 PTH1R PTH1R BBS1 BBS1 HYAL3 HYAL3 GPLD1 GPLD1 CD44 CD44 PBXIP1 PBXIP1 HOXA3 HOXA3 SNORC SNORC ATF2 ATF2 CHST11 CHST11 EIF2AK3 EIF2AK3 OSR1 OSR1 SIX2 SIX2 SCX SCX HYAL2 HYAL2 UNCX UNCX RARA RARA RUNX3 RUNX3 TYMS TYMS TGFB1 TGFB1 ANXA6 ANXA6 CTNNB1 CTNNB1 ATP7A ATP7A RARB RARB COMP COMP COL11A1 COL11A1 CER1 CER1 COL1A1 COL1A1 MATN1 MATN1 SRF SRF ZEB1 ZEB1 BBS2 BBS2 GDF5 GDF5 EXT1 EXT1 LTBP3 LTBP3 SFRP2 SFRP2 EXT2 EXT2 PITX1 PITX1 LOC105816687 LOC105816687 LOC105822621 LOC105822621 CCN1 CCN1 MATN3 MATN3 NPPC NPPC COL2A1 COL2A1 MKKS MKKS SNAI1 SNAI1 MAPK14 MAPK14 IFT80 IFT80 HOXA5 HOXA5 ITGB8 ITGB8 HOXB3 HOXB3 BMP1 BMP1 STC1 STC1 RARG RARG BMPR2 BMPR2 DDRGK1 DDRGK1 BMPR1B BMPR1B HOXA11 HOXA11 SOX5 SOX5 ADAMTS12 ADAMTS12 RUNX1 RUNX1 WNT2B WNT2B TAPT1 TAPT1 SMAD5 SMAD5 TGFBI TGFBI COL3A1 COL3A1 GLI3 GLI3 HMGA2 HMGA2 HYAL1 HYAL1 WNT7B WNT7B NOG NOG SULF1 SULF1 TGFBR2 TGFBR2 SCUBE2 SCUBE2 ZBTB16 ZBTB16 WNT10B WNT10B IHH IHH WNT7A WNT7A HAND2 HAND2 SOX6 SOX6 COL27A1 COL27A1 DLX2 DLX2 TRIP11 TRIP11 EPYC EPYC PKD1 PKD1 RUNX2 RUNX2 BMP7 BMP7 MYF5 MYF5 CHRDL2 CHRDL2 HIF1A HIF1A LOC105805030 LOC105805030 OTOR OTOR SMAD1 SMAD1 CHSY1 CHSY1 SMPD3 SMPD3 FGF9 FGF9 ARID5A ARID5A PRRX1 PRRX1 EDN1 EDN1 ESRRA ESRRA AXIN2 AXIN2 WNT5A WNT5A EVC EVC MAPK3 MAPK3 CREB3L2 CREB3L2 HES5 HES5 SNAI2 SNAI2 MEF2C MEF2C LOC105819868 LOC105819868 SERPINH1 SERPINH1 ZMPSTE24 ZMPSTE24 SULF2 SULF2 BMP5 BMP5 ADAMTS7 ADAMTS7 RB1 RB1 NFIB NFIB HOXD3 HOXD3 SLC39A14 SLC39A14 BMPR1A BMPR1A TWSG1 TWSG1 THBS3 THBS3 CCN2 CCN2 CNMD CNMD BGN BGN RSPO2 RSPO2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (458 aa)
MMP13Matrix metallopeptidase 13. (386 aa)
SHOX2Short stature homeobox 2. (355 aa)
BARX2BARX homeobox 2. (281 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
IMPAD1Inositol monophosphatase domain containing 1. (359 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
SNX19Sorting nexin 19. (1000 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
SOX9SRY-box transcription factor 9. (505 aa)
MEF2DMyocyte enhancer factor 2D. (519 aa)
ECM1Extracellular matrix protein 1. (570 aa)
HOXC4Homeobox C4. (264 aa)
THRAThyroid hormone receptor alpha. (645 aa)
MUSTN1Uncharacterized protein. (86 aa)
GDF2Growth differentiation factor 2. (427 aa)
MEX3CMex-3 RNA binding family member C. (656 aa)
BMP6Bone morphogenetic protein 6. (509 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
GHRLGhrelin and obestatin prepropeptide. (116 aa)
COL11A2Collagen type XI alpha 2 chain. (1736 aa)
FGFR3Fibroblast growth factor receptor. (807 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (590 aa)
BBS1BBS1 domain-containing protein. (593 aa)
HYAL3Hyaluronidase. (417 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (813 aa)
CD44CD44 molecule (Indian blood group). (746 aa)
PBXIP1PBX homeobox interacting protein 1. (723 aa)
HOXA3Homeobox A3. (444 aa)
SNORCSecondary ossification center associated regulator of chondrocyte maturation. (121 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
SIX2SIX homeobox 2. (296 aa)
SCXScleraxis bHLH transcription factor. (208 aa)
HYAL2Hyaluronidase. (473 aa)
UNCXUNC homeobox. (533 aa)
RARARetinoic acid receptor alpha. (472 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (433 aa)
TYMSThymidylate synthetase. (313 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ANXA6Annexin. (650 aa)
CTNNB1Catenin beta 1. (781 aa)
ATP7AATPase copper transporting alpha. (1502 aa)
RARBRetinoic acid receptor beta. (448 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
COL11A1Collagen type XI alpha 1 chain. (1670 aa)
CER1Cerberus 1, DAN family BMP antagonist. (267 aa)
COL1A1Collagen type I alpha 1 chain. (1461 aa)
MATN1Matrilin 1. (499 aa)
SRFSerum response factor. (508 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1002 aa)
BBS2Bardet-Biedl syndrome 2. (614 aa)
GDF5Growth differentiation factor 5. (499 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1306 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (539 aa)
PITX1Homeobox protein. (272 aa)
LOC105816687Uncharacterized protein. (80 aa)
LOC105822621Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CCN1Cellular communication network factor 1. (381 aa)
MATN3Matrilin 3. (488 aa)
NPPCNatriuretic peptide C. (126 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
IFT80Intraflagellar transport 80. (721 aa)
HOXA5Homeobox A5. (270 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (768 aa)
HOXB3Homeobox B3. (426 aa)
BMP1Metalloendopeptidase. (986 aa)
STC1Stanniocalcin 1. (247 aa)
RARGRetinoic acid receptor gamma. (458 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
DDRGK1DDRGK domain containing 1. (315 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (500 aa)
HOXA11Homeobox A11. (316 aa)
SOX5SRY-box transcription factor 5. (763 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1602 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (478 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
TAPT1Transmembrane anterior posterior transformation 1. (567 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
TGFBITransforming growth factor beta induced. (683 aa)
COL3A1Collagen type III alpha 1 chain. (1371 aa)
GLI3GLI family zinc finger 3. (1580 aa)
HMGA2Uncharacterized protein. (117 aa)
HYAL1Hyaluronidase. (435 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SULF1Sulfatase 1. (863 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (994 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (190 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
SOX6SRY-box transcription factor 6. (828 aa)
COL27A1Fibrillar collagen NC1 domain-containing protein. (1893 aa)
DLX2Distal-less homeobox 2. (328 aa)
TRIP11Thyroid hormone receptor interactor 11. (1951 aa)
EPYCEpiphycan. (322 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4265 aa)
RUNX2RUNX family transcription factor 2. (539 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
CHRDL2Chordin like 2. (446 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
LOC105805030Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (150 aa)
OTOROtoraplin. (128 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
CHSY1Hexosyltransferase. (804 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ARID5AAT-rich interaction domain 5A. (591 aa)
PRRX1Paired related homeobox 1. (245 aa)
EDN1Endothelin 1. (193 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
AXIN2Axin 2. (716 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
EVCEvC ciliary complex subunit 1. (992 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (508 aa)
HES5Orange domain-containing protein. (94 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
SERPINH1Serpin family H member 1; Belongs to the serpin family. (418 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
SULF2Sulfatase 2. (850 aa)
BMP5Bone morphogenetic protein 5. (379 aa)
ADAMTS7ADAM metallopeptidase with thrombospondin type 1 motif 7. (1663 aa)
RB1RB transcriptional corepressor 1. (787 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
HOXD3Homeobox D3. (432 aa)
SLC39A14Solute carrier family 39 member 14. (490 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (484 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (189 aa)
THBS3Thrombospondin 3. (956 aa)
CCN2Cellular communication network factor 2. (347 aa)
CNMDChondromodulin. (287 aa)
BGNBiglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (378 aa)
RSPO2R-spondin 2. (243 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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