STRINGSTRING
ZDHHC1 ZDHHC1 USP27X USP27X MX2 MX2 IL21 IL21 ENSPCOP00000020218 ENSPCOP00000020218 PML PML BCL2L1 BCL2L1 IFNG IFNG BCL2 BCL2 ENSPCOP00000021139 ENSPCOP00000021139 EIF2AK4 EIF2AK4 RNF135 RNF135 RIOK3 RIOK3 SPON2 SPON2 ZNF175 ZNF175 ENSPCOP00000021800 ENSPCOP00000021800 FADD FADD NDUFAF4 NDUFAF4 ARMC5 ARMC5 TANK TANK GBP1 GBP1 UNC93B1 UNC93B1 POLR3G POLR3G PARP9 PARP9 ENSPCOP00000023239 ENSPCOP00000023239 OAS2 OAS2 CXCL9 CXCL9 FCN3 FCN3 HYAL2 HYAL2 CXCL10 CXCL10 AGBL5 AGBL5 MAP3K14 MAP3K14 POLR3C POLR3C SHFL SHFL RELA RELA CARD9 CARD9 PYCARD PYCARD TRIM28 TRIM28 LOC105815151 LOC105815151 RIPK3 RIPK3 POLR3A POLR3A NLRP1 NLRP1 ACOD1 ACOD1 DDX1 DDX1 POLR3D POLR3D MYD88 MYD88 LOC105811802 LOC105811802 KCNJ8 KCNJ8 ZBP1 ZBP1 NLRP6 NLRP6 MX1 MX1 TRIM41 TRIM41 DDX58 DDX58 ZMYND11 ZMYND11 ENSPCOP00000028657 ENSPCOP00000028657 CNOT7 CNOT7 ENSPCOP00000028506 ENSPCOP00000028506 UNC13D UNC13D LOC105816571 LOC105816571 IFIT3 IFIT3 AIM2 AIM2 IFIT1 IFIT1 ENSPCOP00000000202 ENSPCOP00000000202 TRIM8 TRIM8 ZNFX1 ZNFX1 IFNGR2 IFNGR2 ENSPCOP00000001062 ENSPCOP00000001062 SETD2 SETD2 PHB PHB POLR3F POLR3F TRIM5 TRIM5 IRF2 IRF2 ZC3H12A ZC3H12A TTC4 TTC4 ISG20 ISG20 BPIFA1 BPIFA1 OPRK1 OPRK1 ENSPCOP00000008287 ENSPCOP00000008287 IL6 IL6 ENSPCOP00000008247 ENSPCOP00000008247 ENSPCOP00000008058 ENSPCOP00000008058 STAT1 STAT1 IFNE IFNE SLFN13 SLFN13 IRF9 IRF9 TRAF3 TRAF3 MBL2 MBL2 TLR9 TLR9 ENSPCOP00000006977 ENSPCOP00000006977 POLR3B POLR3B PLA2G10 PLA2G10 DDX17 DDX17 DTX3L DTX3L EIF2AK2 EIF2AK2 RNASEL RNASEL MID2 MID2 IRF3 IRF3 TRIM52 TRIM52 POLR3H POLR3H PQBP1 PQBP1 LOC105820524 LOC105820524 AKAP1 AKAP1 STING1 STING1 DDX50 DDX50 ZCCHC3 ZCCHC3 DHX36 DHX36 IRF5 IRF5 ITCH ITCH RSAD2 RSAD2 PMAIP1 PMAIP1 CD207 CD207 DDX60 DDX60 IRF1 IRF1 GBP2 GBP2 TLR3 TLR3 IL23A IL23A NMBR NMBR SAMHD1 SAMHD1 ENSPCOP00000009677 ENSPCOP00000009677 ENSPCOP00000009822 ENSPCOP00000009822 ENSPCOP00000009901 ENSPCOP00000009901 GPAM GPAM TRIM11 TRIM11 STAT2 STAT2 VAPB VAPB IFIT5 IFIT5 DHX15 DHX15 IRF7 IRF7 RTP4 RTP4 PRF1 PRF1 ADAR ADAR ATG16L1 ATG16L1 TRIM26 TRIM26 ISG15 ISG15 ENSPCOP00000012130 ENSPCOP00000012130 IL12B IL12B NLRC5 NLRC5 LOC105814886 LOC105814886 TRIM27 TRIM27 NLRP3 NLRP3 POLR3K POLR3K IL33 IL33 CASP1 CASP1 ELMOD2 ELMOD2 ENSPCOP00000015022 ENSPCOP00000015022 BNIP3 BNIP3 DDX21 DDX21 DNAJC3 DNAJC3 TLR8 TLR8 SENP7 SENP7 IFI6 IFI6 AZU1 AZU1 LYST LYST ILF3 ILF3 AGBL4 AGBL4 NCBP1 NCBP1 NMB NMB MLKL MLKL TBK1 TBK1 IFNLR1 IFNLR1 ADARB1 ADARB1 EXOSC5 EXOSC5 FAM71E1 FAM71E1 SERINC5 SERINC5 ZC3HAV1 ZC3HAV1 CGAS CGAS EXOSC4 EXOSC4 LOC105816515 LOC105816515 DDIT4 DDIT4 DHX58 DHX58 ATG7 ATG7 IFIH1 IFIH1 MAVS MAVS IFNL1 IFNL1 ENSPCOP00000019705 ENSPCOP00000019705 HERC5 HERC5 MOV10 MOV10 POLR3E POLR3E ABCF3 ABCF3 TRIM32 TRIM32 LOC105822732 LOC105822732 IFNAR2 IFNAR2 NT5C3A NT5C3A LOC105826437 LOC105826437 IKBKE IKBKE SERINC3 SERINC3 ENSPCOP00000027612 ENSPCOP00000027612 OASL OASL BNIP3L BNIP3L PDE12 PDE12 CLPB CLPB SKP2 SKP2 IFIT2 IFIT2 TRIM25 TRIM25 PCBP2 PCBP2 VAMP8 VAMP8 TICAM1 TICAM1 CD40 CD40
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZDHHC1Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (481 aa)
USP27XUbiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (438 aa)
MX2MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (710 aa)
IL21Interleukin 21. (110 aa)
ENSPCOP00000020218CMP/dCMP-type deaminase domain-containing protein. (131 aa)
PMLPromyelocytic leukemia. (887 aa)
BCL2L1BCL2 like 1. (233 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
ENSPCOP00000021139Sec3-PIP2_bind domain-containing protein. (386 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1650 aa)
RNF135Ring finger protein 135. (421 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
SPON2Spondin 2. (332 aa)
ZNF175Zinc finger protein 175. (719 aa)
ENSPCOP00000021800Uncharacterized protein. (175 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (205 aa)
NDUFAF4NADH:ubiquinone oxidoreductase complex assembly factor 4. (174 aa)
ARMC5Armadillo repeat containing 5. (931 aa)
TANKTRAF family member associated NFKB activator. (425 aa)
GBP1Guanylate binding protein 1. (577 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (600 aa)
POLR3GUncharacterized protein. (82 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (857 aa)
ENSPCOP00000023239RING-type domain-containing protein. (105 aa)
OAS22'-5'-oligoadenylate synthetase 2. (704 aa)
CXCL9C-X-C motif chemokine. (126 aa)
FCN3Ficolin 3. (299 aa)
HYAL2Hyaluronidase. (473 aa)
CXCL10C-X-C motif chemokine. (98 aa)
AGBL5ATP/GTP binding protein like 5. (887 aa)
MAP3K14Uncharacterized protein. (151 aa)
POLR3CRNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (463 aa)
SHFLShiftless antiviral inhibitor of ribosomal frameshifting. (288 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CARD9Caspase recruitment domain family member 9. (536 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TRIM28Tripartite motif containing 28. (833 aa)
LOC105815151Uncharacterized protein. (913 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (516 aa)
POLR3ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1390 aa)
NLRP1NLR family pyrin domain containing 1. (1253 aa)
ACOD1Aconitate decarboxylase 1. (478 aa)
DDX1DEAD-box helicase 1. (723 aa)
POLR3DRNA polymerase III subunit D. (398 aa)
MYD88MYD88 innate immune signal transduction adaptor. (353 aa)
LOC105811802Uncharacterized protein. (249 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (424 aa)
ZBP1Z-DNA binding protein 1. (415 aa)
NLRP6NLR family pyrin domain containing 6. (890 aa)
MX1MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (652 aa)
TRIM41Tripartite motif containing 41. (629 aa)
DDX58DExD/H-box helicase 58. (688 aa)
ZMYND11Zinc finger MYND-type containing 11. (470 aa)
ENSPCOP00000028657Uncharacterized protein. (79 aa)
CNOT7Uncharacterized protein. (303 aa)
ENSPCOP00000028506DZF domain-containing protein. (112 aa)
UNC13DUnc-13 homolog D. (1109 aa)
LOC105816571Uncharacterized protein. (133 aa)
IFIT3Interferon induced protein with tetratricopeptide repeats 3. (483 aa)
AIM2Absent in melanoma 2. (260 aa)
IFIT1Interferon induced protein with tetratricopeptide repeats 1. (472 aa)
ENSPCOP00000000202Prohibitin. (262 aa)
TRIM8Tripartite motif containing 8. (551 aa)
ZNFX1Zinc finger NFX1-type containing 1. (1916 aa)
IFNGR2Interferon gamma receptor 2. (304 aa)
ENSPCOP00000001062CMP/dCMP-type deaminase domain-containing protein. (167 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2565 aa)
PHBProhibitin. (272 aa)
POLR3FDNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (316 aa)
TRIM5Uncharacterized protein. (482 aa)
IRF2Interferon regulatory factor 2. (350 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (598 aa)
TTC4Tetratricopeptide repeat domain 4. (387 aa)
ISG20Interferon stimulated exonuclease gene 20. (174 aa)
BPIFA1BPI fold containing family A member 1. (259 aa)
OPRK1Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
ENSPCOP00000008287Uncharacterized protein. (126 aa)
IL6Uncharacterized protein. (211 aa)
ENSPCOP00000008247Uncharacterized protein. (164 aa)
ENSPCOP00000008058Uncharacterized protein. (1607 aa)
STAT1Signal transducer and activator of transcription. (794 aa)
IFNEInterferon epsilon. (178 aa)
SLFN13Schlafen family member 13. (892 aa)
IRF9Interferon regulatory factor 9. (393 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
MBL2Mannose binding lectin 2. (247 aa)
TLR9TIR domain-containing protein. (1029 aa)
ENSPCOP00000006977IRF-3 domain-containing protein. (275 aa)
POLR3BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1085 aa)
PLA2G10Phospholipase A(2). (165 aa)
DDX17DEAD-box helicase 17; Belongs to the DEAD box helicase family. (735 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (733 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (549 aa)
RNASELRibonuclease L. (741 aa)
MID2Midline 2. (735 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (419 aa)
TRIM52Tripartite motif containing 52. (301 aa)
POLR3HRNA polymerase III subunit H. (204 aa)
PQBP1Polyglutamine binding protein 1. (265 aa)
LOC105820524Uncharacterized protein. (201 aa)
AKAP1A-kinase anchoring protein 1. (867 aa)
STING1Transmembrane protein 173. (374 aa)
DDX50DExD-box helicase 50. (595 aa)
ZCCHC3Zinc finger CCHC-type containing 3. (401 aa)
DHX36HA2 domain-containing protein. (718 aa)
IRF5Interferon regulatory factor 5. (502 aa)
ITCHE3 ubiquitin-protein ligase. (860 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (361 aa)
PMAIP1Uncharacterized protein. (54 aa)
CD207CD207 molecule. (329 aa)
DDX60DExD/H-box helicase 60. (1661 aa)
IRF1Interferon regulatory factor. (324 aa)
GBP2Guanylate binding protein 2. (591 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
NMBRNeuromedin B receptor; Belongs to the G-protein coupled receptor 1 family. (390 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (400 aa)
ENSPCOP00000009677TFG domain-containing protein. (334 aa)
ENSPCOP00000009822Uncharacterized protein. (396 aa)
ENSPCOP00000009901CMP/dCMP-type deaminase domain-containing protein. (202 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (787 aa)
TRIM11Tripartite motif containing 11. (468 aa)
STAT2Signal transducer and activator of transcription. (862 aa)
VAPBVAMP associated protein B and C. (216 aa)
IFIT5Interferon induced protein with tetratricopeptide repeats 5. (482 aa)
DHX15DEAH-box helicase 15. (754 aa)
IRF7Interferon regulatory factor 7. (383 aa)
RTP4Receptor transporter protein 4. (245 aa)
PRF1Perforin 1. (555 aa)
ADARAdenosine deaminase RNA specific. (1174 aa)
ATG16L1Autophagy related 16 like 1. (609 aa)
TRIM26Tripartite motif containing 26. (534 aa)
ISG15ISG15 ubiquitin like modifier. (174 aa)
ENSPCOP00000012130CMP/dCMP-type deaminase domain-containing protein. (156 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
NLRC5NLR family CARD domain containing 5. (1812 aa)
LOC105814886CMP/dCMP-type deaminase domain-containing protein. (132 aa)
TRIM27Tripartite motif containing 27. (513 aa)
NLRP3NLR family pyrin domain containing 3. (1036 aa)
POLR3KDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
IL33Interleukin 33. (274 aa)
CASP1Uncharacterized protein; Belongs to the peptidase C14A family. (254 aa)
ELMOD2ELMO domain containing 2. (248 aa)
ENSPCOP00000015022APOBEC_N domain-containing protein. (67 aa)
BNIP3Uncharacterized protein. (235 aa)
DDX21DExD-box helicase 21. (758 aa)
DNAJC3DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1039 aa)
SENP7SUMO specific peptidase 7. (1012 aa)
IFI6Interferon alpha inducible protein 6. (131 aa)
AZU1Azurocidin 1. (250 aa)
LYSTLysosomal trafficking regulator. (3630 aa)
ILF3Interleukin enhancer binding factor 3. (900 aa)
AGBL4ATP/GTP binding protein like 4. (491 aa)
NCBP1Nuclear cap binding protein subunit 1. (654 aa)
NMBNeuromedin B. (121 aa)
MLKLMixed lineage kinase domain like pseudokinase. (419 aa)
TBK1TANK binding kinase 1. (690 aa)
IFNLR1Fibronectin type-III domain-containing protein. (244 aa)
ADARB1Adenosine deaminase RNA specific B1. (725 aa)
EXOSC5Exosome component 5. (235 aa)
FAM71E1Family with sequence similarity 71 member E1. (215 aa)
SERINC5Serine incorporator 5. (418 aa)
ZC3HAV1Zinc finger CCCH-type containing, antiviral 1. (889 aa)
CGASCyclic GMP-AMP synthase. (523 aa)
EXOSC4Exosome component 4. (245 aa)
LOC105816515Uncharacterized protein. (133 aa)
DDIT4DNA damage inducible transcript 4. (230 aa)
DHX58DExH-box helicase 58. (678 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (704 aa)
IFIH1Interferon induced with helicase C domain 1. (1025 aa)
MAVSMitochondrial antiviral signaling protein. (514 aa)
IFNL1Interferon lambda 1. (191 aa)
ENSPCOP00000019705Uncharacterized protein. (583 aa)
HERC5HECT and RLD domain containing E3 ubiquitin protein ligase 5. (1023 aa)
MOV10Mov10 RISC complex RNA helicase. (1004 aa)
POLR3ERNA polymerase III subunit E. (708 aa)
ABCF3ATP binding cassette subfamily F member 3. (709 aa)
TRIM32Uncharacterized protein. (653 aa)
LOC105822732Uncharacterized protein. (245 aa)
IFNAR2Uncharacterized protein. (520 aa)
NT5C3A5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (303 aa)
LOC105826437E3 ubiquitin-protein ligase TRIM32. (653 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
SERINC3Serine incorporator 3. (473 aa)
ENSPCOP00000027612Uncharacterized protein. (131 aa)
OASL2'-5'-oligoadenylate synthetase like. (511 aa)
BNIP3LBCL2 interacting protein 3 like. (219 aa)
PDE12Phosphodiesterase 12. (609 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (707 aa)
SKP2S-phase kinase associated protein 2. (436 aa)
IFIT2Interferon induced protein with tetratricopeptide repeats 2. (463 aa)
TRIM25Tripartite motif containing 25. (633 aa)
PCBP2Poly(rC) binding protein 2. (366 aa)
VAMP8Vesicle associated membrane protein 8. (100 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (692 aa)
CD40CD40 molecule. (281 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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