STRINGSTRING
CD28 CD28 RRAS RRAS PTPRJ PTPRJ SESN3 SESN3 MUL1 MUL1 TCF7L2 TCF7L2 LOC105809759 LOC105809759 NOP53 NOP53 LEMD2 LEMD2 NTS NTS GATA3 GATA3 NRG1 NRG1 TEK TEK VEGFB VEGFB XDH XDH C1QTNF6 C1QTNF6 RCN3 RCN3 TNFAIP8L3 TNFAIP8L3 INPP5F INPP5F GRM2 GRM2 CIB1 CIB1 MTDH MTDH C1QTNF1 C1QTNF1 FAM110C FAM110C HAX1 HAX1 HBEGF HBEGF FERMT2 FERMT2 LEP LEP ENSPCOP00000005855 ENSPCOP00000005855 LOC105824853 LOC105824853 LOC105825287 LOC105825287 CAV3 CAV3 PHLDA3 PHLDA3 XBP1 XBP1 RASD2 RASD2 STK11 STK11 CAVIN3 CAVIN3 C1QBP C1QBP P2RX4 P2RX4 LRP2 LRP2 DRD2 DRD2 FGFR1 FGFR1 MTOR MTOR PTEN PTEN PHB PHB NTRK2 NTRK2 RNF41 RNF41 MYOC MYOC GCNT2 GCNT2 IGFBP5 IGFBP5 OSM OSM GAS6 GAS6 CCL21 CCL21 ENSPCOP00000000202 ENSPCOP00000000202 CCR7 CCR7 CHI3L1 CHI3L1 INPP5K INPP5K HPSE HPSE RAMP3 RAMP3 TNFSF11 TNFSF11 CSF3 CSF3 BAG4 BAG4 C1QTNF12 C1QTNF12 RICTOR RICTOR IGF2 IGF2 PIK3CD PIK3CD MAGI2 MAGI2 OTUD3 OTUD3 PARK7 PARK7 SH2B3 SH2B3 HIP1 HIP1 PLEKHA1 PLEKHA1 FAM110B FAM110B ENSPCOP00000028353 ENSPCOP00000028353 LIN28A LIN28A SIRT1 SIRT1 GATA4 GATA4 RTN4 RTN4 SPRY2 SPRY2 PKHD1 PKHD1 ENSPCOP00000026834 ENSPCOP00000026834 PHLPP1 PHLPP1 MYDGF MYDGF PTK2 PTK2 INSR INSR PPP2CA PPP2CA CRYBA1 CRYBA1 MEIS3 MEIS3 PDGFA PDGFA THBS1 THBS1 PINK1 PINK1 ENSPCOP00000024480 ENSPCOP00000024480 RACK1 RACK1 F3 F3 HYAL2 HYAL2 SLC9A3R1 SLC9A3R1 VEGFA VEGFA CCL19 CCL19 RET RET CALCR CALCR AXL AXL DAG1 DAG1 MST1R MST1R PIK3R5 PIK3R5 HNF1A HNF1A FLCN FLCN TGFB1 TGFB1 ITGB1BP1 ITGB1BP1 ENSPCOP00000022475 ENSPCOP00000022475 IL26 IL26 IGF1R IGF1R ANGPT1 ANGPT1 OSBPL8 OSBPL8 ENG ENG MAZ MAZ CX3CL1 CX3CL1 BANK1 BANK1 STK3 STK3 TGFBR1 TGFBR1 SRC SRC ADAM8 ADAM8 EGFR EGFR CX3CR1 CX3CR1 SFRP5 SFRP5 PIK3CB PIK3CB TSC2 TSC2 GDF15 GDF15 GFRAL GFRAL PIK3CG PIK3CG ENSPCOP00000015642 ENSPCOP00000015642 PIK3CA PIK3CA CASS4 CASS4 ENSPCOP00000015413 ENSPCOP00000015413 TNF TNF DLG1 DLG1 EGF EGF MSTN MSTN ENSPCOP00000013862 ENSPCOP00000013862 MFHAS1 MFHAS1 NRXN1 NRXN1 STOX1 STOX1 EPHA2 EPHA2 LOC105824854 LOC105824854 DDIT3 DDIT3 PPARA PPARA NTRK1 NTRK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD28CD28 molecule. (220 aa)
RRASRAS related. (220 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1223 aa)
SESN3Sestrin 3. (495 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
LOC105809759CCHC-type domain-containing protein. (176 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (417 aa)
LEMD2LEM domain containing 2. (503 aa)
NTSNeurotensin. (170 aa)
GATA3Uncharacterized protein. (444 aa)
NRG1Neuregulin 1. (710 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
XDHXanthine dehydrogenase. (1313 aa)
C1QTNF6C1q and TNF related 6. (263 aa)
RCN3Reticulocalbin 3. (320 aa)
TNFAIP8L3TNF alpha induced protein 8 like 3. (285 aa)
INPP5FInositol polyphosphate-5-phosphatase F. (1132 aa)
GRM2Glutamate metabotropic receptor 2. (872 aa)
CIB1Calcium and integrin binding 1. (191 aa)
MTDHMetadherin. (580 aa)
C1QTNF1C1q and TNF related 1. (281 aa)
FAM110CFamily with sequence similarity 110 member C. (348 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (278 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
FERMT2Fermitin family member 2. (693 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ENSPCOP00000005855Uncharacterized protein. (259 aa)
LOC105824853Uncharacterized protein. (401 aa)
LOC105825287DJ-1_PfpI domain-containing protein. (189 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
PHLDA3Pleckstrin homology like domain family A member 3. (125 aa)
XBP1BZIP domain-containing protein. (377 aa)
RASD2RASD family member 2. (266 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
CAVIN3Caveolae associated protein 3. (286 aa)
C1QBPUncharacterized protein. (281 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (402 aa)
LRP2LDL receptor related protein 2. (4654 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
FGFR1Fibroblast growth factor receptor. (846 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PHBProhibitin. (272 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
RNF41Ring finger protein 41. (317 aa)
MYOCMyocilin. (504 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (329 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
OSMOncostatin M. (251 aa)
GAS6Growth arrest specific 6. (648 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
ENSPCOP00000000202Prohibitin. (262 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (385 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (447 aa)
HPSEHeparanase. (395 aa)
RAMP3Receptor activity modifying protein 3. (151 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (320 aa)
CSF3Colony stimulating factor 3. (199 aa)
BAG4BCL2 associated athanogene 4. (457 aa)
C1QTNF12C1q and TNF related 12. (294 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1646 aa)
IGF2Insulin like growth factor 2. (236 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1453 aa)
OTUD3OTU deubiquitinase 3. (398 aa)
PARK7DJ-1_PfpI domain-containing protein. (155 aa)
SH2B3SH2B adaptor protein 3. (539 aa)
HIP1Huntingtin interacting protein 1. (1037 aa)
PLEKHA1Pleckstrin homology domain containing A1. (400 aa)
FAM110BFamily with sequence similarity 110 member B. (370 aa)
ENSPCOP00000028353Uncharacterized protein. (130 aa)
LIN28ACCHC-type domain-containing protein. (209 aa)
SIRT1Sirtuin 1. (743 aa)
GATA4GATA binding protein 4. (445 aa)
RTN4Reticulon. (1195 aa)
SPRY2Sprouty RTK signaling antagonist 2. (314 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (3878 aa)
ENSPCOP00000026834Uncharacterized protein. (276 aa)
PHLPP1PH domain and leucine rich repeat protein phosphatase 1. (1710 aa)
MYDGFMyeloid derived growth factor. (173 aa)
PTK2Protein tyrosine kinase 2. (1089 aa)
INSRInsulin receptor. (1192 aa)
PPP2CASerine/threonine-protein phosphatase. (295 aa)
CRYBA1Crystallin beta A1; Belongs to the beta/gamma-crystallin family. (215 aa)
MEIS3Meis homeobox 3. (420 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
THBS1Thrombospondin 1. (1185 aa)
PINK1PTEN induced kinase 1. (581 aa)
ENSPCOP00000024480Uncharacterized protein. (103 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (294 aa)
HYAL2Hyaluronidase. (473 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (353 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
CCL19C-C motif chemokine. (108 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1079 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (479 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
DAG1Dystroglycan 1. (895 aa)
MST1RMacrophage stimulating 1 receptor. (1403 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (879 aa)
HNF1AHNF1 homeobox A. (662 aa)
FLCNFolliculin. (579 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
ENSPCOP00000022475Uncharacterized protein. (173 aa)
IL26Interleukin 26. (171 aa)
IGF1RTyrosine-protein kinase receptor. (1350 aa)
ANGPT1Angiopoietin 1. (408 aa)
OSBPL8Oxysterol binding protein like 8. (797 aa)
ENGEndoglin. (657 aa)
MAZMYC associated zinc finger protein. (493 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (405 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (567 aa)
STK3Serine/threonine kinase 3. (500 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (421 aa)
SRCTyrosine-protein kinase. (543 aa)
ADAM8ADAM metallopeptidase domain 8. (812 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (379 aa)
SFRP5Secreted frizzled related protein 5. (315 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TSC2TSC complex subunit 2. (1814 aa)
GDF15Growth differentiation factor 15. (310 aa)
GFRALGDNF family receptor alpha like. (338 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
ENSPCOP00000015642DJ-1_PfpI domain-containing protein. (175 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
CASS4Cas scaffold protein family member 4. (774 aa)
ENSPCOP00000015413CCHC-type domain-containing protein. (191 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (910 aa)
EGFEpidermal growth factor. (1132 aa)
MSTNMyostatin. (376 aa)
ENSPCOP00000013862SER_THR_PHOSPHATASE domain-containing protein. (209 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1037 aa)
NRXN1Neurexin 1. (1449 aa)
STOX1Storkhead box 1. (980 aa)
EPHA2EPH receptor A2. (976 aa)
LOC105824854Uncharacterized protein. (312 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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