(35 nodes) Regulation of cardiac muscle cell proliferation network (Propithecus coquereli)

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second shell of interactors

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	NKX2-5	NK2 homeobox 5. (324 aa)
	KCNK2	Potassium two pore domain channel subfamily K member 2. (371 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	TBX2	T-box transcription factor 2. (713 aa)
	NOTCH1	Notch receptor 1. (2420 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	BMP10	Bone morphogenetic protein 10. (423 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1240 aa)
	PIM1	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (401 aa)
	NRG1	Neuregulin 1. (710 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	LOC105819868	Protein kinase domain-containing protein. (302 aa)
	VGLL4	Vestigial like family member 4. (296 aa)
	SAV1	Salvador family WW domain containing protein 1. (384 aa)
	YAP1	Uncharacterized protein. (504 aa)
	GLI1	GLI family zinc finger 1. (1106 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (484 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (588 aa)
	MAPK11	Mitogen-activated protein kinase. (443 aa)
	ZFPM2	Zinc finger protein, FOG family member 2. (1151 aa)
	TGFBR3	Transforming growth factor beta receptor 3. (851 aa)
	MAPK14	Mitogen-activated protein kinase 14. (340 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (421 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
	ENSPCOP00000025005	Uncharacterized protein. (351 aa)
	GATA6	GATA binding protein 6. (593 aa)
	ENSPCOP00000029403	Protein kinase domain-containing protein. (429 aa)
	FGFR2	Fibroblast growth factor receptor. (797 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	TBX20	T-box transcription factor 20. (447 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP10	BMPR1A	ENSPCOP00000006872	ENSPCOP00000011972	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.794
BMP10	NOG	ENSPCOP00000006872	ENSPCOP00000000944	Bone morphogenetic protein 10.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.643
BMP10	TGFBR1	ENSPCOP00000006872	ENSPCOP00000018681	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.792
BMP10	TGFBR2	ENSPCOP00000006872	ENSPCOP00000001360	Bone morphogenetic protein 10.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.642
BMPR1A	BMP10	ENSPCOP00000011972	ENSPCOP00000006872	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Bone morphogenetic protein 10.	0.794
BMPR1A	ENSPCOP00000025005	ENSPCOP00000011972	ENSPCOP00000025005	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.564
BMPR1A	ENSPCOP00000029403	ENSPCOP00000011972	ENSPCOP00000029403	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.449
BMPR1A	LOC105819868	ENSPCOP00000011972	ENSPCOP00000009415	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.457
BMPR1A	MAPK11	ENSPCOP00000011972	ENSPCOP00000014799	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.432
BMPR1A	MAPK14	ENSPCOP00000011972	ENSPCOP00000017367	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase 14.	0.457
BMPR1A	NOG	ENSPCOP00000011972	ENSPCOP00000000944	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.497
BMPR1A	PTEN	ENSPCOP00000011972	ENSPCOP00000001519	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.567
BMPR1A	TGFBR2	ENSPCOP00000011972	ENSPCOP00000001360	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.881
BMPR1A	TGFBR3	ENSPCOP00000011972	ENSPCOP00000016709	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Transforming growth factor beta receptor 3.	0.404
BMPR1A	WNT2	ENSPCOP00000011972	ENSPCOP00000030382	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.500
BMPR1A	YAP1	ENSPCOP00000011972	ENSPCOP00000011436	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.564
ENSPCOP00000025005	BMPR1A	ENSPCOP00000025005	ENSPCOP00000011972	Uncharacterized protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.564
ENSPCOP00000025005	ENSPCOP00000029403	ENSPCOP00000025005	ENSPCOP00000029403	Uncharacterized protein.	Protein kinase domain-containing protein.	0.922
ENSPCOP00000025005	NOTCH1	ENSPCOP00000025005	ENSPCOP00000004691	Uncharacterized protein.	Notch receptor 1.	0.404
ENSPCOP00000025005	PTEN	ENSPCOP00000025005	ENSPCOP00000001519	Uncharacterized protein.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.460