STRINGSTRING
DVL3 DVL3 WNT2B WNT2B WNT7B WNT7B PTEN PTEN WNT10B WNT10B WNT7A WNT7A PYGO1 PYGO1 FZD9 FZD9 FZD5 FZD5 FOXD1 FOXD1 LEF1 LEF1 FZD7 FZD7 SIAH2 SIAH2 EDA EDA WNT11 WNT11 FGF9 FGF9 DIXDC1 DIXDC1 DVL2 DVL2 EDN1 EDN1 SOSTDC1 SOSTDC1 WNT5A WNT5A HESX1 HESX1 CTDNEP1 CTDNEP1 WNT1 WNT1 LRP6 LRP6 WNT16 WNT16 WNT9A WNT9A KLF4 KLF4 GATA3 GATA3 FZD8 FZD8 FZD3 FZD3 BCL9 BCL9 SIAH1 SIAH1 WNT6 WNT6 YAP1 YAP1 FOXO1 FOXO1 JUP JUP TCF7L2 TCF7L2 ISL1 ISL1 RYK RYK BCL9L BCL9L ENSPCOP00000013694 ENSPCOP00000013694 RSPO2 RSPO2 EDNRB EDNRB STK4 STK4 FZD4 FZD4 ENSPCOP00000014590 ENSPCOP00000014590 RARG RARG TCF7 TCF7 SFRP1 SFRP1 LGR4 LGR4 WNT2 WNT2 AXIN1 AXIN1 TCF7L1 TCF7L1 EDNRA EDNRA WNT10A WNT10A SOX9 SOX9 LATS2 LATS2 ENSPCOP00000028788 ENSPCOP00000028788 WNT8B WNT8B PPP1CA PPP1CA DVL1 DVL1 WNT8A WNT8A CDH3 CDH3 PYGO2 PYGO2 WNT3A WNT3A CAV1 CAV1 ENSPCOP00000025005 ENSPCOP00000025005 LRRK2 LRRK2 WNT3 WNT3 SDC1 SDC1 DACT3 DACT3 PLPP3 PLPP3 GSK3B GSK3B CTNNB1 CTNNB1 WNT9B WNT9B ENSPCOP00000022492 ENSPCOP00000022492 WNT4 WNT4 SOST SOST DKK1 DKK1 STK3 STK3 EXT1 EXT1 SFRP2 SFRP2 FZD2 FZD2 ENSPCOP00000018033 ENSPCOP00000018033 SCYL2 SCYL2 SFRP4 SFRP4 RECK RECK SFRP5 SFRP5 ENSPCOP00000016328 ENSPCOP00000016328
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DVL3Dishevelled segment polarity protein 3. (716 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (190 aa)
PYGO1Pygopus family PHD finger 1. (419 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
FOXD1Forkhead box D1. (467 aa)
LEF1Lymphoid enhancer binding factor 1. (432 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
DIXDC1DIX domain containing 1. (683 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
EDN1Endothelin 1. (193 aa)
SOSTDC1Sclerostin domain containing 1. (229 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
HESX1HESX homeobox 1. (184 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1579 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
KLF4Uncharacterized protein. (486 aa)
GATA3Uncharacterized protein. (444 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (406 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (312 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
YAP1Uncharacterized protein. (504 aa)
FOXO1Forkhead box O1. (656 aa)
JUPJunction plakoglobin. (745 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
ISL1ISL LIM homeobox 1. (349 aa)
RYKReceptor like tyrosine kinase. (606 aa)
BCL9LBCL9 like. (1497 aa)
ENSPCOP00000013694Uncharacterized protein. (199 aa)
RSPO2R-spondin 2. (243 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (485 aa)
STK4Serine/threonine kinase 4. (487 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
ENSPCOP00000014590Uncharacterized protein. (118 aa)
RARGRetinoic acid receptor gamma. (458 aa)
TCF7Transcription factor 7. (303 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (920 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
AXIN1Axin 1. (865 aa)
TCF7L1Transcription factor 7 like 1. (590 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
SOX9SRY-box transcription factor 9. (505 aa)
LATS2Non-specific serine/threonine protein kinase. (1073 aa)
ENSPCOP00000028788Uncharacterized protein. (171 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
DVL1Dishevelled segment polarity protein 1. (722 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (825 aa)
PYGO2Pygopus family PHD finger 2. (407 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
ENSPCOP00000025005Uncharacterized protein. (351 aa)
LRRK2Leucine rich repeat kinase 2. (2427 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
DACT3Dishevelled binding antagonist of beta catenin 3. (631 aa)
PLPP3acidPPc domain-containing protein. (312 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (390 aa)
CTNNB1Catenin beta 1. (781 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
ENSPCOP00000022492Uncharacterized protein. (356 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
SOSTSclerostin. (213 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (268 aa)
STK3Serine/threonine kinase 3. (500 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (547 aa)
ENSPCOP00000018033HH_signal domain-containing protein. (110 aa)
SCYL2SCY1 like pseudokinase 2. (933 aa)
SFRP4Secreted frizzled related protein 4. (342 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (969 aa)
SFRP5Secreted frizzled related protein 5. (315 aa)
ENSPCOP00000016328Uncharacterized protein. (111 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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