(35 nodes) Wnt signaling pathway, planar cell polarity pathway network (Propithecus coquereli)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	SMURF2	SMAD specific E3 ubiquitin protein ligase 2. (602 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	PRICKLE1	Prickle planar cell polarity protein 1. (831 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (190 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
	ROR1	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	PRICKLE2	Prickle planar cell polarity protein 2. (902 aa)
	DVL2	Dishevelled segment polarity protein 2. (736 aa)
	VANGL1	Vang-like protein. (524 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (943 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1072 aa)
	RYK	Receptor like tyrosine kinase. (606 aa)
	FZD6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
	CTHRC1	Collagen triple helix repeat containing 1. (246 aa)
	ARHGEF19	Rho guanine nucleotide exchange factor 19. (811 aa)
	DVL3	Dishevelled segment polarity protein 3. (716 aa)
	CELSR1	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2924 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (547 aa)
	SFRP2	Secreted frizzled related protein 2. (295 aa)
	VANGL2	Vang-like protein. (550 aa)
	SMURF1	E3 ubiquitin-protein ligase. (744 aa)
	GRHL3	Grainyhead like transcription factor 3. (597 aa)
	MED12	Mediator complex subunit 12. (2187 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	GPC4	Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
	CELSR3	Cadherin EGF LAG seven-pass G-type receptor 3; Belongs to the G-protein coupled receptor 2 family. (3313 aa)
	DVL1	Dishevelled segment polarity protein 1. (722 aa)
	TIAM1	T cell lymphoma invasion and metastasis 1. (1590 aa)
	DAAM1	Dishevelled associated activator of morphogenesis 1. (1076 aa)
	CELSR2	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2921 aa)
	MAGI2	Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1453 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF19	DAAM1	ENSPCOP00000016395	ENSPCOP00000028498	Rho guanine nucleotide exchange factor 19.	Dishevelled associated activator of morphogenesis 1.	0.575
CELSR1	DAAM1	ENSPCOP00000016541	ENSPCOP00000028498	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Dishevelled associated activator of morphogenesis 1.	0.504
CELSR1	DVL1	ENSPCOP00000016541	ENSPCOP00000026920	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Dishevelled segment polarity protein 1.	0.495
CELSR1	DVL2	ENSPCOP00000016541	ENSPCOP00000006637	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Dishevelled segment polarity protein 2.	0.499
CELSR1	FZD3	ENSPCOP00000016541	ENSPCOP00000009843	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.632
CELSR1	FZD6	ENSPCOP00000016541	ENSPCOP00000015630	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.693
CELSR1	PRICKLE1	ENSPCOP00000016541	ENSPCOP00000002075	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Prickle planar cell polarity protein 1.	0.632
CELSR1	PRICKLE2	ENSPCOP00000016541	ENSPCOP00000006341	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Prickle planar cell polarity protein 2.	0.614
CELSR1	PTK7	ENSPCOP00000016541	ENSPCOP00000012721	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.426
CELSR1	VANGL1	ENSPCOP00000016541	ENSPCOP00000007323	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Vang-like protein.	0.742
CELSR1	VANGL2	ENSPCOP00000016541	ENSPCOP00000020356	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Vang-like protein.	0.746
CELSR2	FZD3	ENSPCOP00000029223	ENSPCOP00000009843	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.529
CELSR2	FZD6	ENSPCOP00000029223	ENSPCOP00000015630	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.551
CELSR2	PRICKLE1	ENSPCOP00000029223	ENSPCOP00000002075	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	Prickle planar cell polarity protein 1.	0.493
CELSR2	PRICKLE2	ENSPCOP00000029223	ENSPCOP00000006341	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	Prickle planar cell polarity protein 2.	0.444
CELSR2	VANGL1	ENSPCOP00000029223	ENSPCOP00000007323	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	Vang-like protein.	0.730
CELSR2	VANGL2	ENSPCOP00000029223	ENSPCOP00000020356	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	Vang-like protein.	0.639
CELSR3	FZD3	ENSPCOP00000025578	ENSPCOP00000009843	Cadherin EGF LAG seven-pass G-type receptor 3; Belongs to the G-protein coupled receptor 2 family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.665
CELSR3	FZD6	ENSPCOP00000025578	ENSPCOP00000015630	Cadherin EGF LAG seven-pass G-type receptor 3; Belongs to the G-protein coupled receptor 2 family.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.514
CELSR3	PRICKLE1	ENSPCOP00000025578	ENSPCOP00000002075	Cadherin EGF LAG seven-pass G-type receptor 3; Belongs to the G-protein coupled receptor 2 family.	Prickle planar cell polarity protein 1.	0.495