STRINGSTRING
LRRK2 LRRK2 GLRA1 GLRA1 MECP2 MECP2 CHRNE CHRNE HTR3E HTR3E NPFF NPFF GRID1 GRID1 GRIK5 GRIK5 CHRNA7 CHRNA7 TRPV1 TRPV1 GABRB3 GABRB3 GSK3B GSK3B CHRNG CHRNG GABRB2 GABRB2 GABRR3 GABRR3 GABRQ GABRQ GABRA4 GABRA4 GRIN1 GRIN1 GABRR2 GABRR2 CHRND CHRND GRM1 GRM1 INSYN2A INSYN2A CHRNA1 CHRNA1 GABBR1 GABBR1 CHRNB2 CHRNB2 GABRA2 GABRA2 CHRNA2 CHRNA2 CHRNA6 CHRNA6 CHRNB3 CHRNB3 P2RX1 P2RX1 RGS7BP RGS7BP GRIA1 GRIA1 DGKI DGKI SEZ6 SEZ6 GSK3A GSK3A CHRNA4 CHRNA4 GABRP GABRP CHRNB1 CHRNB1 ZACN ZACN MEF2C MEF2C ENSPCOP00000009166 ENSPCOP00000009166 GLRA2 GLRA2 CFAP299 CFAP299 GLRB GLRB MAPK8IP2 MAPK8IP2 P2RX2 P2RX2 HCRT HCRT GLRA3 GLRA3 PPP3CA PPP3CA ENSPCOP00000005485 ENSPCOP00000005485 RAB3GAP1 RAB3GAP1 CHRM1 CHRM1 HTR3B HTR3B GABRE GABRE CHRNB4 CHRNB4 GRIN2D GRIN2D ENSPCOP00000003181 ENSPCOP00000003181 P2RX5 P2RX5 P2RX4 P2RX4 GRIN3A GRIN3A GABRA3 GABRA3 ADORA2A ADORA2A GRIN2A GRIN2A P2RX6 P2RX6 GABRR1 GABRR1 CHRNA3 CHRNA3 CHRNA10 CHRNA10 CHRNA9 CHRNA9 GABRA5 GABRA5 GABRD GABRD GRM5 GRM5 NPAS4 NPAS4 GABRB1 GABRB1 P2RX7 P2RX7 AKT1 AKT1 GRIK4 GRIK4 LOC105807078 LOC105807078 GLRA4 GLRA4 INSYN1 INSYN1 SLC29A1 SLC29A1 GHRL GHRL CHRNA5 CHRNA5 GRIN2C GRIN2C GABRG3 GABRG3 DRD4 DRD4 GRIN2B GRIN2B P2RX3 P2RX3 CDK5 CDK5 HTR3A HTR3A GRID2 GRID2 GABRG1 GABRG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRRK2Leucine rich repeat kinase 2. (2427 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (500 aa)
CHRNECholinergic receptor nicotinic epsilon subunit. (493 aa)
HTR3E5-hydroxytryptamine receptor 3E; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
NPFFNeuropeptide FF-amide peptide precursor. (113 aa)
GRID1Glutamate ionotropic receptor delta type subunit 1. (930 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (980 aa)
CHRNA7Uncharacterized protein. (531 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (845 aa)
GABRB3Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (529 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (390 aa)
CHRNGCholinergic receptor nicotinic gamma subunit. (519 aa)
GABRB2Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (430 aa)
GABRR3Gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene); Belongs to the ligand-gated ion channel (TC 1.A.9) family. (401 aa)
GABRQGamma-aminobutyric acid type A receptor theta subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (632 aa)
GABRA4Gamma-aminobutyric acid type A receptor alpha4 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (504 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
GABRR2Gamma-aminobutyric acid type A receptor rho2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (465 aa)
CHRNDCholinergic receptor nicotinic delta subunit. (517 aa)
GRM1Glutamate metabotropic receptor 1. (1188 aa)
INSYN2AInhibitory synaptic factor 2A. (478 aa)
CHRNA1Cholinergic receptor nicotinic alpha 1 subunit. (479 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (962 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (502 aa)
GABRA2Gamma-aminobutyric acid type A receptor alpha2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (450 aa)
CHRNA2Cholinergic receptor nicotinic alpha 2 subunit. (529 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (487 aa)
CHRNB3Cholinergic receptor nicotinic beta 3 subunit. (457 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
RGS7BPRegulator of G protein signaling 7 binding protein. (257 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
DGKIDiacylglycerol kinase. (1082 aa)
SEZ6Seizure related 6 homolog. (994 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (623 aa)
GABRPGamma-aminobutyric acid type A receptor pi subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (440 aa)
CHRNB1Cholinergic receptor nicotinic beta 1 subunit. (502 aa)
ZACNZinc activated ion channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (411 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ENSPCOP00000009166Uncharacterized protein. (231 aa)
GLRA2Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (451 aa)
CFAP299Uncharacterized protein. (81 aa)
GLRBGlycine receptor beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (466 aa)
MAPK8IP2Mitogen-activated protein kinase 8 interacting protein 2. (828 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (473 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (131 aa)
GLRA3Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (398 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ENSPCOP00000005485Uncharacterized protein. (75 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (916 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
HTR3B5-hydroxytryptamine receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (442 aa)
GABREGamma-aminobutyric acid type A receptor epsilon subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (508 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (471 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1337 aa)
ENSPCOP00000003181PBPe domain-containing protein. (242 aa)
P2RX5P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (404 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (402 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1115 aa)
GABRA3Gamma-aminobutyric acid type A receptor alpha3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (492 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (411 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
P2RX6P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (440 aa)
GABRR1Gamma-aminobutyric acid type A receptor rho1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (481 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (500 aa)
CHRNA10Cholinergic receptor nicotinic alpha 10 subunit. (450 aa)
CHRNA9Cholinergic receptor nicotinic alpha 9 subunit. (479 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
GABRDGamma-aminobutyric acid type A receptor delta subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (483 aa)
GRM5Glutamate metabotropic receptor 5. (1211 aa)
NPAS4Neuronal PAS domain protein 4. (804 aa)
GABRB1Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (474 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (956 aa)
LOC105807078Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (437 aa)
GLRA4Glycine receptor alpha 4; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
INSYN1Inhibitory synaptic factor 1. (292 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (456 aa)
GHRLGhrelin and obestatin prepropeptide. (116 aa)
CHRNA5Cholinergic receptor nicotinic alpha 5 subunit. (469 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1234 aa)
GABRG3Gamma-aminobutyric acid type A receptor gamma3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (468 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (333 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1485 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
HTR3A5-hydroxytryptamine receptor 3A; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (483 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (962 aa)
GABRG1Gamma-aminobutyric acid type A receptor gamma1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (271 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.