(23 nodes) Cardiac epithelial to mesenchymal transition network (Propithecus coquereli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMP2	Bone morphogenetic protein 2. (395 aa)
	MSX1	Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	HEYL	Hes related family bHLH transcription factor with YRPW motif like. (328 aa)
	OLFM1	Olfactomedin 1. (485 aa)
	SNAI2	Snail family transcriptional repressor 2. (268 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	HAS2	Hyaluronan synthase 2. (552 aa)
	EFNA1	Ephrin A1; Belongs to the ephrin family. (205 aa)
	TGFBR3	Transforming growth factor beta receptor 3. (851 aa)
	SNAI1	Snail family transcriptional repressor 1. (264 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (421 aa)
	ENG	Endoglin. (657 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	ADAM15	ADAM metallopeptidase domain 15. (859 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (319 aa)
	RTN4	Reticulon. (1195 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	ENSPCOP00000005396	Uncharacterized protein. (130 aa)
	NOTCH1	Notch receptor 1. (2420 aa)
	HEY1	Hes related family bHLH transcription factor with YRPW motif 1. (308 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	ENG	ENSPCOP00000030823	ENSPCOP00000020963	Bone morphogenetic protein 2.	Endoglin.	0.537
BMP2	ENSPCOP00000005396	ENSPCOP00000030823	ENSPCOP00000005396	Bone morphogenetic protein 2.	Uncharacterized protein.	0.449
BMP2	FGF8	ENSPCOP00000030823	ENSPCOP00000012774	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.455
BMP2	MSX1	ENSPCOP00000030823	ENSPCOP00000029785	Bone morphogenetic protein 2.	Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity).	0.448
BMP2	NOTCH1	ENSPCOP00000030823	ENSPCOP00000004691	Bone morphogenetic protein 2.	Notch receptor 1.	0.405
BMP2	SMAD4	ENSPCOP00000030823	ENSPCOP00000024999	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.923
BMP2	TGFBR1	ENSPCOP00000030823	ENSPCOP00000018681	Bone morphogenetic protein 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.881
BMP2	TGFBR3	ENSPCOP00000030823	ENSPCOP00000016709	Bone morphogenetic protein 2.	Transforming growth factor beta receptor 3.	0.510
BMP2	WNT2	ENSPCOP00000030823	ENSPCOP00000030382	Bone morphogenetic protein 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.496
ENG	BMP2	ENSPCOP00000020963	ENSPCOP00000030823	Endoglin.	Bone morphogenetic protein 2.	0.537
ENG	SMAD4	ENSPCOP00000020963	ENSPCOP00000024999	Endoglin.	Mothers against decapentaplegic homolog.	0.435
ENG	TGFB2	ENSPCOP00000020963	ENSPCOP00000001330	Endoglin.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.504
ENG	TGFBR1	ENSPCOP00000020963	ENSPCOP00000018681	Endoglin.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.884
ENSPCOP00000005396	BMP2	ENSPCOP00000005396	ENSPCOP00000030823	Uncharacterized protein.	Bone morphogenetic protein 2.	0.449
FGF8	BMP2	ENSPCOP00000012774	ENSPCOP00000030823	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 2.	0.455
FGF8	MSX1	ENSPCOP00000012774	ENSPCOP00000029785	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity).	0.463
FGF8	SPRY1	ENSPCOP00000012774	ENSPCOP00000026347	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Sprouty RTK signaling antagonist 1.	0.408
HEY1	HEY2	ENSPCOP00000002949	ENSPCOP00000030472	Hes related family bHLH transcription factor with YRPW motif 1.	Hes related family bHLH transcription factor with YRPW motif 2.	0.978
HEY1	HEYL	ENSPCOP00000002949	ENSPCOP00000000325	Hes related family bHLH transcription factor with YRPW motif 1.	Hes related family bHLH transcription factor with YRPW motif like.	0.863
HEY1	NOTCH1	ENSPCOP00000002949	ENSPCOP00000004691	Hes related family bHLH transcription factor with YRPW motif 1.	Notch receptor 1.	0.758