(25 nodes) Innervation network (Propithecus coquereli)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LRIG2	Leucine rich repeats and immunoglobulin like domains 2. (875 aa)
	GABRB2	Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (430 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (409 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1079 aa)
	POU4F1	POU domain protein. (421 aa)
	LRIG1	Leucine rich repeats and immunoglobulin like domains 1. (1063 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	GABRA5	Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	RNF165	Ring finger protein 165. (347 aa)
	NTRK1	Tyrosine-protein kinase receptor. (796 aa)
	SULF2	Sulfatase 2. (850 aa)
	COL25A1	Collagen type XXV alpha 1 chain. (654 aa)
	NPTX1	Neuronal pentraxin 1. (432 aa)
	SEMA3A	Semaphorin 3A; Belongs to the semaphorin family. (619 aa)
	EDN1	Endothelin 1. (193 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2997 aa)
	FBXO45	F-box protein 45. (284 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
	SULF1	Sulfatase 1. (863 aa)
	ECE1	Endothelin converting enzyme 1. (758 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (964 aa)
	ADARB1	Adenosine deaminase RNA specific B1. (725 aa)
	VCAM1	Vascular cell adhesion molecule 1. (739 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COL25A1	ITGA4	ENSPCOP00000010385	ENSPCOP00000001645	Collagen type XXV alpha 1 chain.	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	0.404
ECE1	EDN1	ENSPCOP00000001378	ENSPCOP00000006922	Endothelin converting enzyme 1.	Endothelin 1.	0.852
ECE1	EDNRA	ENSPCOP00000001378	ENSPCOP00000029676	Endothelin converting enzyme 1.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.549
EDN1	ECE1	ENSPCOP00000006922	ENSPCOP00000001378	Endothelin 1.	Endothelin converting enzyme 1.	0.852
EDN1	EDNRA	ENSPCOP00000006922	ENSPCOP00000029676	Endothelin 1.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.998
EDNRA	ECE1	ENSPCOP00000029676	ENSPCOP00000001378	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin converting enzyme 1.	0.549
EDNRA	EDN1	ENSPCOP00000029676	ENSPCOP00000006922	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.998
GABRA5	GABRB2	ENSPCOP00000031998	ENSPCOP00000022066	Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.907
GABRB2	GABRA5	ENSPCOP00000022066	ENSPCOP00000031998	Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.907
ISL1	POU4F1	ENSPCOP00000012878	ENSPCOP00000024710	ISL LIM homeobox 1.	POU domain protein.	0.511
ITGA4	COL25A1	ENSPCOP00000001645	ENSPCOP00000010385	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	Collagen type XXV alpha 1 chain.	0.404
ITGA4	VCAM1	ENSPCOP00000001645	ENSPCOP00000017297	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	Vascular cell adhesion molecule 1.	0.948
LRIG1	LRIG2	ENSPCOP00000027581	ENSPCOP00000021552	Leucine rich repeats and immunoglobulin like domains 1.	Leucine rich repeats and immunoglobulin like domains 2.	0.715
LRIG1	RET	ENSPCOP00000027581	ENSPCOP00000023769	Leucine rich repeats and immunoglobulin like domains 1.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.550
LRIG2	LRIG1	ENSPCOP00000021552	ENSPCOP00000027581	Leucine rich repeats and immunoglobulin like domains 2.	Leucine rich repeats and immunoglobulin like domains 1.	0.715
NRP1	NTRK1	ENSPCOP00000017048	ENSPCOP00000010652	Neuropilin; Belongs to the neuropilin family.	Tyrosine-protein kinase receptor.	0.540
NRP1	RET	ENSPCOP00000017048	ENSPCOP00000023769	Neuropilin; Belongs to the neuropilin family.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.528
NRP1	SEMA3A	ENSPCOP00000017048	ENSPCOP00000007058	Neuropilin; Belongs to the neuropilin family.	Semaphorin 3A; Belongs to the semaphorin family.	0.996
NTRK1	NRP1	ENSPCOP00000010652	ENSPCOP00000017048	Tyrosine-protein kinase receptor.	Neuropilin; Belongs to the neuropilin family.	0.540
NTRK1	RET	ENSPCOP00000010652	ENSPCOP00000023769	Tyrosine-protein kinase receptor.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.744