STRINGSTRING
SLIT3 SLIT3 BMPR2 BMPR2 HEY2 HEY2 FGFR2 FGFR2 SOX11 SOX11 BMP4 BMP4 EGLN1 EGLN1 SMAD4 SMAD4 CITED2 CITED2 FZD2 FZD2 TGFBR1 TGFBR1 ACVR1 ACVR1 TGFBR3 TGFBR3 NSD2 NSD2 RBM15 RBM15 NKX2-5 NKX2-5 HEYL HEYL SOX4 SOX4 NOG NOG SMAD7 SMAD7 TGFB2 TGFB2 TGFBR2 TGFBR2 ENSPCOP00000001901 ENSPCOP00000001901 HEY1 HEY1 NOTCH1 NOTCH1 ROBO1 ROBO1 ENSPCOP00000005396 ENSPCOP00000005396 WNT11 WNT11 WNT5A WNT5A FGFRL1 FGFRL1 ENSPCOP00000009764 ENSPCOP00000009764 ZFPM1 ZFPM1 NOS3 NOS3 ENSPCOP00000010769 ENSPCOP00000010769 SAV1 SAV1 BMPR1A BMPR1A SLIT2 SLIT2 ROBO2 ROBO2 PROX1 PROX1 ZFPM2 ZFPM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLIT3Slit guidance ligand 3. (1523 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
FGFR2Fibroblast growth factor receptor. (797 aa)
SOX11Transcription factor SOX. (442 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
EGLN1Uncharacterized protein. (427 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (547 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (421 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1364 aa)
RBM15RNA binding motif protein 15. (971 aa)
NKX2-5NK2 homeobox 5. (324 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
SOX4Transcription factor SOX. (479 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SMAD7Mothers against decapentaplegic homolog. (490 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ENSPCOP00000001901Ig-like domain-containing protein. (127 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (308 aa)
NOTCH1Notch receptor 1. (2420 aa)
ROBO1Uncharacterized protein. (1334 aa)
ENSPCOP00000005396Uncharacterized protein. (130 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FGFRL1Fibroblast growth factor receptor like 1. (509 aa)
ENSPCOP00000009764Ig-like domain-containing protein. (130 aa)
ZFPM1Zinc finger protein, FOG family member 1. (728 aa)
NOS3Nitric oxide synthase 3. (994 aa)
ENSPCOP00000010769Ig-like domain-containing protein. (119 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (484 aa)
SLIT2Slit guidance ligand 2. (1423 aa)
ROBO2Roundabout guidance receptor 2. (1323 aa)
PROX1Prospero homeobox 1. (737 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1151 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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