STRINGSTRING
SRC SRC FGF10 FGF10 ATP2C2 ATP2C2 MST1 MST1 FOXB1 FOXB1 HIF1A HIF1A AREG AREG MED1 MED1 ENSPCOP00000005396 ENSPCOP00000005396 NTN1 NTN1 STAT6 STAT6 CSF1 CSF1 LOC105822779 LOC105822779 SOSTDC1 SOSTDC1 WNT5A WNT5A FOXF1 FOXF1 PRLR PRLR EPHA2 EPHA2 MGMT MGMT CSMD1 CSMD1 VDR VDR LATS1 LATS1 KDM5B KDM5B IRF6 IRF6 DDR1 DDR1 HOXA5 HOXA5 AR AR TNFSF11 TNFSF11 IQGAP3 IQGAP3 WNT2 WNT2 FGFR2 FGFR2 LRRC1 LRRC1 MAPK1 MAPK1 MSX1 MSX1 CCND1 CCND1 ENSPCOP00000029403 ENSPCOP00000029403 ID2 ID2 AKT1 AKT1 LRP5 LRP5 CEBPB CEBPB SMO SMO PGR PGR CSMD2 CSMD2 CSF1R CSF1R ZNF703 ZNF703 WNT3 WNT3 ESR1 ESR1 TGFB1 TGFB1 PTCH1 PTCH1 ORAI1 ORAI1 AGAP2 AGAP2 BTRC BTRC WNT4 WNT4 SCRIB SCRIB PML PML AKT2 AKT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRCTyrosine-protein kinase. (543 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ATP2C2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (964 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
FOXB1Forkhead box B1. (325 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
AREGAmphiregulin. (253 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
ENSPCOP00000005396Uncharacterized protein. (130 aa)
NTN1Netrin 1. (604 aa)
STAT6Signal transducer and activator of transcription. (846 aa)
CSF1Colony stimulating factor 1. (438 aa)
LOC105822779Uncharacterized protein. (325 aa)
SOSTDC1Sclerostin domain containing 1. (229 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FOXF1Forkhead box F1. (381 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (523 aa)
EPHA2EPH receptor A2. (976 aa)
MGMTO-6-methylguanine-DNA methyltransferase. (241 aa)
CSMD1CUB and Sushi multiple domains 1. (3147 aa)
VDRVitamin D receptor. (474 aa)
LATS1Large tumor suppressor kinase 1. (1131 aa)
KDM5BLysine demethylase 5B. (1544 aa)
IRF6Interferon regulatory factor 6. (467 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (913 aa)
HOXA5Homeobox A5. (270 aa)
ARAndrogen receptor. (886 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (320 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1607 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FGFR2Fibroblast growth factor receptor. (797 aa)
LRRC1Leucine rich repeat containing 1. (484 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ENSPCOP00000029403Protein kinase domain-containing protein. (429 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
PGRNuclear receptor domain-containing protein. (592 aa)
CSMD2CUB and Sushi multiple domains 2. (3597 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
ZNF703Zinc finger protein 703. (589 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (599 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PTCH1Patched 1. (1449 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (307 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1193 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (609 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
SCRIBScribble planar cell polarity protein. (1598 aa)
PMLPromyelocytic leukemia. (887 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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